PDGFC - platelet derived growth factor C Gene

Homo sapiens

Also known as SCDGF; FALLOTEIN

Gene ID: 56034 | Gene type: protein coding

About PDGFC

Cytogenetic location: 4q32.1 Genomic coordinates (GRCh38): 4:156,760,454-156,971,799 (from NCBI)

This gene has 9 transcripts (splice variants), 204 orthologues and 35 paralogues. Ubiquitous expression in endometrium (RPKM 16.6), prostate (RPKM 13.9) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]

PDGFC Products(1)

mRNA	Protein	Name
NM_016205.3	NP_057289.1	platelet-derived growth factor C precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables platelet-derived growth factor receptor binding	IPI IPI: Inferred from physical interaction	10806482	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10806482	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	10806482	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in platelet-derived growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	10806482	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	10806482	GOA
involved in positive regulation of fibroblast proliferation	IDA IDA: Inferred from direct assay	10806482	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	10806482	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	10806482	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDGFC Protein Structure

CUB

PDGF

0
100
200
300
345 a.a.

Protein Preferred Names

Protein Names

platelet-derived growth factor C

PDGF-C

Recombinant PDGFC Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7279	PDGF-CC Protein, Human (HEK293)	Q9NRA1-1 (V235-G345)	≥95%
HY-P73353	PDGF-CC Protein, Human (HEK293, Fc)	Q9NRA1-1 (V235-G345)	≥95%

Related Diseases

Diseases

Alias

Milker'S Nodule

Poxviridae Infections	Milker Nodule
Milkers' Node	Paravaccinia
Pseudocowpox	Milker'S Nodes

Medulloblastoma

MDB	Cpnet
Localized Primitive Neuroectodermal Tumor	Classic Medulloblastoma
Medulloblastoma Predisposition Syndrome	Medulloblastoma, Somatic
Brain Medulloblastoma	Cns Pnet
Infratentorial Primitive Neuroectodermal Tumor	Neuroectodermal Tumors, Primitive
Medulloblastomas	Desmoplastic Medulloblastoma
Medulloblastoma, With Extensive Nodularity	Medulloblastoma Of Unspecified Site
Medullomyoblastoma Of Unspecified Site

Macular Degeneration, Age-Related, 1

Macular Degeneration	Age-Related Macular Degeneration
Macular Degeneration, Age-Related	Age Related Macular Degeneration
Age Related Macular Degeneration 1	ARMD1
Senile Macular Degeneration	Maculopathy, Age-Related, 1
Macular Degeneration, Age-Related, Reduced Risk Of	Age Related Maculopathy 1
Age Related Maculopathies	Age Related Maculopathy
Senile Macular Retinal Degeneration	Macular Degeneration Of Retina
Age-Related Maculopathy	Amd
Armd	Age-Related Maculopathy, Susceptibility To
Maculopathy Age-Related	Macular Degeneration, Age-Related, 1, Susceptibility To
Maculopathy, Age-Related	Macular Degeneration, Age-Related, Type 1
Macular Degeneration, Age-Related, 2

Contagious Pustular Dermatitis

Ecthyma, Contagious	Orf
Ecthyma Contagiosum	Scabby Mouth
Sheep Pox	Thistle Disease
Contagious Pustular Dermatosis

Bronchiectasis 2

Petrous Apex Meningioma

Meningioma Of The Petrous Ridge

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Cleft Palate, Isolated

Cleft Palate	Isolated Cleft Palate
CPI	Cp
Palatoschisis	Cleft Palate Isolated
Uranostaphyloschisis	Congenital Fissure Of Palate
Cleft Of Secondary Palate

Orofacial Cleft

Cleft, Orofacial

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10252	PDGFC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PDGFC	VGNC	VGNC:44370
Mus musculus	PDGFC	MGD	MGI:1859631
Rattus norvegicus	PDGFC	RGD	RGD:68410
Bos taurus	PDGFC	VGNC	VGNC:53915
Macaca mulatta	PDGFC	VGNC	VGNC:75928
Felis catus	PDGFC	VGNC	VGNC:68771

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