Hgs - hepatocyte growth factor-regulated tyrosine kinase substrate Gene

Rattus norvegicus

Also known as Hrs

Gene ID: 56084 | Gene type: protein coding

About Hgs

Summary

Predicted to enable several functions, including identical protein binding activity; ubiquitin-dependent protein binding activity; and ubiquitin-like protein Ligase binding activity. Involved in endosome to lysosome transport. Located in cytosol; membrane; and secretory granule. Orthologous to human HGS (hepatocyte growth factor-regulated tyrosine kinase substrate). [provided by Alliance of Genome Resources, Apr 2022]

Hgs Products(3)

mRNA	Protein	Name
NM_001399619.1	NP_001386548.1	hepatocyte growth factor-regulated tyrosine kinase substrate isoform 2
NM_001399620.1	NP_001386549.1	hepatocyte growth factor-regulated tyrosine kinase substrate isoform 3
NM_019387.3	NP_062260.2	hepatocyte growth factor-regulated tyrosine kinase substrate isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10825299	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in endosome to lysosome transport	IMP IMP: Inferred from mutant phenotype	19808888	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in secretory granule	IDA IDA: Inferred from direct assay	10825299	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

hepatocyte growth factor-regulated tyrosine kinase substrate

HGF-regulated tyrosine kinase substrate

SNAP-25-interacting protein Hrs-2

Hgs Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Hgs	Q9JJ50	Hap1	Rattus norvegicus	P54256	Anti Bait CoIP	12021262
Intra	Hgs	Q9JJ50	Hap1	Rattus norvegicus	P54256	Pull Down	12021262
Intra	Hgs	Q9JJ50	Hap1	Rattus norvegicus	P54256	Y2H	12021262
Intra	Hgs	Q9JJ50	Hap1	Rattus norvegicus	P54256-2	Density Sedimentation	12021262
Intra	Hgs	Q9JJ50	Hap1	Rattus norvegicus	P54256-2	Confocal	12021262
Intra	Hgs	Q9JJ50	Hap1	Rattus norvegicus	P54256-2	Pull Down	12021262

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99299	Lexatumumab	Inducer	96.95%	Phase 2

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06155	HGS Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990592	GSK-3050002		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hgs	NCBI	NCBI:9146

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