2. Apoptosis
  3. Apoptosis
  4. Lexatumumab

Lexatumumab  (Synonyms: HGS-ETR 2; ETR2-ST01)

Cat. No.: HY-P99299 Purity: 96.95%
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Lexatumumab (HGS-ETR 2) is a human agonistic TRAIL receptor 2 (TRAIL-R2, DR5, APO-2) IgG4κ type monoclonal antibody. Lexatumumab induces apoptosis in malignant mesothelioma. Lexatumumab can be used for malignant pleural mesothelioma (MPM) research.

For research use only. We do not sell to patients.

CAS No. : 845816-02-6

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5 mg USD 780 In-stock
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Based on 1 publication(s) in Google Scholar

Lexatumumab Related Antibodies

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Description

Lexatumumab (HGS-ETR 2) is a human agonistic TRAIL receptor 2 (TRAIL-R2, DR5, APO-2) IgG4κ type monoclonal antibody. Lexatumumab induces apoptosis in malignant mesothelioma. Lexatumumab can be used for malignant pleural mesothelioma (MPM) research[1].

Isotype

Human IgG1 lambda1
Recommend Isotype Controls
Species

Human
IC50 & Target

TRAIL-R2[1]
In Vitro

The combination of Cisplatin (HY-17394) with Lexatumumab synergistically inhibits the cell growth and enhanced apoptotic death[1].
Lexatumumab (0-10 µg/ml, 72 h) induces various degrees of cell death in the different melanoma cell lines[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lexatumumab Related Antibodies

Cell Viability Assay[2]

Cell Line: Melanoma cell lines
Concentration: 0.01, 0.1, 1.0 and 10.0 µg/ml
Incubation Time: 72 h
Result: Induced various degrees of cell death in the different cell lines.
In Vivo

Lexatumumab (10 mg/kg, i.v., twice a week) increases antitumor effect in vivo when combined with Dacarbazine (HY-B0078)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: FEMX-1 xenografts mice[2]
Dosage: 10 mg/kg, 10 mg/kg+Dacarbazine (62.5 mg/kg once a week, i.p. injection)
Administration: i.v., twice a week
Result: Increased antitumor effect in vivo when combined with Dacarbazine (HY-B0078). Induced cleavage of livin into its truncated, proapoptotic form, a compound previously shown to accelerate apoptosis.
Clinical Trial
Molecular Weight

143.6 (kDa)

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Lexatumumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 lambda2
Biological Activity
  • Immobilized Human DR5/TRAIL R2 Protein (His Tag) can bind Lexatumumab. The EC50 for this effect is 1.14 ng/mL.
Purity & Documentation
References
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Lexatumumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lexatumumab845816-02-6HGS-ETR 2 ETR2-ST01Apoptosismalignant pleural mesotheliomaMPM cellH2052SPC212H226FEMX-1 cellsanticancerInhibitorinhibitorinhibit

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