2. Gene
  3. PRLR - prolactin receptor Gene

PRLR - prolactin receptor Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HPRL; MFAB; hPRLrI; RI-PRLR

Gene ID: 5618 | Gene type: protein coding

About PRLR

Cytogenetic location: 5p13.2 Genomic coordinates (GRCh38): 5:35,048,756-35,230,487 (from NCBI)

This gene has 20 transcripts (splice variants), 269 orthologues, 23 paralogues and is associated with 3 phenotypes. Biased expression in placenta (RPKM 18.9), endometrium (RPKM 11.6) and 8 other tissues.

Summary

This gene encodes a receptor for the anterior pituitary hormone, Prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the Prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of Prolactin in normal tissue and Cancer. [provided by RefSeq, Feb 2011]

PRLR Products(12)

mRNA Protein Name
NM_000949.7 NP_000940.1 prolactin receptor isoform 1 precursor
NM_001204314.2 NP_001191243.1 prolactin receptor isoform 6 precursor
NM_001204315.1 NP_001191244.1 prolactin receptor isoform 2 precursor
NM_001204316.1 NP_001191245.1 prolactin receptor isoform 3 precursor
NM_001204317.1 NP_001191246.1 prolactin receptor isoform 4 precursor
NM_001204318.1 NP_001191247.1 prolactin receptor isoform 5 precursor
NM_000949.7 NP_000940.1 prolactin receptor isoform 1 precursor
NM_001204314.2 NP_001191243.1 prolactin receptor isoform 6 precursor
NM_001204315.1 NP_001191244.1 prolactin receptor isoform 2 precursor
NM_001204316.1 NP_001191245.1 prolactin receptor isoform 3 precursor
NM_001204317.1 NP_001191246.1 prolactin receptor isoform 4 precursor
NM_001204318.1 NP_001191247.1 prolactin receptor isoform 5 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables lipid binding EXP
EXP: Inferred from Experiment
25846210 GOA
enables lipid binding IPI
IPI: Inferred from physical interaction
25846210 GOA
enables peptide hormone binding IPI
IPI: Inferred from physical interaction
7984244 GOA
enables prolactin receptor activity IDA
IDA: Inferred from direct assay
10585417 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12819209 GOA
Biological Process GO Annotation Evidence Reference Source
involved in activation of Janus kinase activity IDA
IDA: Inferred from direct assay
10585417 GOA
involved in activation of transmembrane receptor protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
10585417 GOA
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
10585417 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cell surface IDA
IDA: Inferred from direct assay
10585417 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRLR Protein Structure

EpoR_lig-bind

EpoR_lig-bind: Erythropoietin receptor, ligand binding (25 - 120)

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  • 622 a.a.
Protein Preferred Names Protein Names

prolactin receptor

hPRL receptor

PRLR Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PRLR P16471 PLPP6 Homo sapiens Q8IY26
Validated Y2H
32296183
Intra
PRLR P16471 YWHAZ Homo sapiens P63104
Pull Down
12819209
Intra
PRLR P16471 INSIG2 Homo sapiens Q9Y5U4
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PRLR Proteins

Cat. No. Product Name Accession Purity
HY-P73696 Prolactin R Protein, Human (HEK293, His) NP_000940.1 (Q25-D234) ≥95%

Related Diseases

Diseases Alias
Hyperprolactinemia

Chiari-Frommel Syndrome

Hyperprolactinaemia

Familial Hyperprolactinemia

HPRL

Pregnancy-Related A-G Syndrome

Familial Isolated Prolactin Receptor Deficiency
Multiple Fibroadenomas Of The Breast

MFAB

Multiple Fibroadenoma Of The Breast

Fibroadenomas, Breast, Multiple
Breast Disease

Breast Diseases
Cerebral Meningioma

Meningioma Of Cerebrum
Premature Menopause

Primary Ovarian Insufficiency

Premature Ovarian Failure

Hypergonadotropic Hypogonadism

Premature Ovarian Insufficiency

Menopause - Premature

Menopause Praecox

Menopause Premature

Menopause, Premature

Female Hypergonadotropic Hypogonadism

Hypergonadotrophic Ovarian Failure

Primary Female Hypogonadism

Pof - [Premature Ovarian Failure]

Ovarian Failure

Ovarian Secretion Suppression

Ovary Hyposecretion

Ovary Secretion Deficiency

Premature Menopause Nos
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Infertility
Galactorrhea

Galactorrhea Not Associated With Childbirth

Galactorrhea Associated With Childbirth
Lipid-Rich Breast Carcinoma
Acromegaly

Gigantism

Growth Hormone Excess

Pituitary Giant

Somatotroph Adenoma

Growth Hormone-Secreting Pituitary Adenoma
Prolactinoma

Prolactin-Producing Pituitary Gland Adenoma

Prolactin-Secreting Pituitary Adenoma

Forbes-Albright Syndrome

Lactotroph Adenoma

Prl-Secreting Pituitary Adenoma

Prloma

Pituitary Lactotrophic Adenoma

Familial Prolactinoma

Pituitary Adenoma, Prolactin-Secreting

Prolactinoma Of Pituitary Gland

PSPA
Breast Adenoma

Ademoma - Breast
Glycogen-Rich Carcinoma

Doid:0081028
Chromophobe Adenoma

Adenoma, Chromophobe

Chromophobe Adenoma Of The Pituitary Gland

Adenoma Chromophobe
Lipid-Rich Carcinoma
Functioning Pituitary Adenoma

Secretory Adenoma Of The Pituitary Gland

Endocrine Active Pituitary Adenoma

Secreting Pituitary Adenoma

Pituitary Adenoma, Functioning
Breast Benign Neoplasm

Benign Tumour Of Breast

Benign Neoplasm Of Female Breast
Thoracic Benign Neoplasm

Benign Neoplasm Of Thorax
Pituitary Gland Disease

Pituitary Diseases

Pituitary Dysfunction

Pituitary Disease

Pituitary Deficiency

Pituitary Disorders
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
Meningioma, Familial

Meningioma

Familial Meningioma

Meningioma, Familial, Susceptibility To

Meningeal Neoplasm

Meningeal Neoplasms

Meningiomas

Meningioma, Nf2-Related, Somatic

Meningioma, Sis-Related

Meningothelial Cell Tumor

Neoplasm Of The Meninges

Primary Meningeal Tumor

Familial Multiple Meningioma

MNGMA

Meningioma, Benign, No Icd-O Subtype

Intracranial Meningioma

Meningothelial Cell Neoplasm

Supratentorial Meningioma

Primary Neoplasm Of Spinal Meninges

Benign Intracranial Meningioma

Benign Meningioma

Meningeal Tumours

Meningeal Sarcoma Of Unspecified Site

Meningothelial Sarcoma Of Unspecified Site
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11163 PRLR Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99238 Rolinsatamab / Unkown
HY-P99881 Rolinsatamab talirine / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PRLR RGD RGD:3407
Felis catus PRLR VGNC VGNC:69076
Bos taurus PRLR VGNC VGNC:33346
Canis familiaris PRLR VGNC VGNC:44994
Macaca mulatta PRLR VGNC VGNC:76423
Mus musculus PRLR MGD MGI:97763
Others PRLR NCBI