MRAP - melanocortin 2 receptor accessory protein Gene

Homo sapiens

Also known as B27; FALP; FGD2; GCCD2; C21orf61

Gene ID: 56246 | Gene type: protein coding

About MRAP

Cytogenetic location: 21q22.11 Genomic coordinates (GRCh38): 21:32,291,813-32,314,784 (from NCBI)

This gene has 4 transcripts (splice variants), 69 orthologues and is associated with 3 phenotypes. Broad expression in fat (RPKM 19.3), adrenal (RPKM 18.8) and 20 other tissues.

Summary

This gene encodes a melanocortin receptor-interacting protein. The encoded protein regulates trafficking and function of the melanocortin 2 receptor in the adrenal gland. The encoded protein can also modulate signaling of Other melanocortin receptors. Mutations in this gene have been associated with familial glucocorticoid deficiency type 2. Alternatively spliced transcript variants have been described. [provided by RefSeq, Dec 2009]

MRAP Products(4)

mRNA	Protein	Name
NM_001285394.2	NP_001272323.1	melanocortin-2 receptor accessory protein isoform c
NM_001379228.1	NP_001366157.1	melanocortin-2 receptor accessory protein isoform alpha
NM_178817.4	NP_848932.1	melanocortin-2 receptor accessory protein isoform alpha
NM_206898.2	NP_996781.1	melanocortin-2 receptor accessory protein isoform beta

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables corticotropin hormone receptor binding	IPI IPI: Inferred from physical interaction	19329486	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	18077336	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18077336	GOA
enables type 1 melanocortin receptor binding	IPI IPI: Inferred from physical interaction	19329486	GOA
enables type 3 melanocortin receptor binding	IPI IPI: Inferred from physical interaction	19329486	GOA
enables type 4 melanocortin receptor binding	IPI IPI: Inferred from physical interaction	19329486	GOA
enables type 5 melanocortin receptor binding	IPI IPI: Inferred from physical interaction	19329486	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	19329486	GOA
involved in negative regulation of protein localization to plasma membrane	IDA IDA: Inferred from direct assay	19329486	GOA
involved in positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	19329486	GOA
involved in protein localization to plasma membrane	IDA IDA: Inferred from direct assay	19329486	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	19329486	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	19329486	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MRAP Protein Structure

MRAP

0
100
172 a.a.

Protein Preferred Names

Protein Names

melanocortin-2 receptor accessory protein

fat cell-specific low molecular weight protein

MRAP Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MRAP	Q8TCY5	CHAT	Homo sapiens	P28329-3	Y2H Pooling	32814053
Intra	MRAP	Q8TCY5	CHAT	Homo sapiens	P28329-3	Validated Y2H	32814053
Intra	MRAP	Q8TCY5	CHAT	Homo sapiens	P28329-3	Y2H Array	32814053
Intra	MRAP	Q8TCY5	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	MRAP	Q8TCY5	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	MRAP	Q8TCY5	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	MRAP	Q8TCY5	MC4R	Homo sapiens	P32245	Anti Tag CoIP	19329486
Intra	MRAP	Q8TCY5	MC2R	Homo sapiens	Q01718	Ub Reconstruction	28298427
Intra	MRAP	Q8TCY5	MC2R	Homo sapiens	Q01718	Anti Tag CoIP	18077336
Intra	MRAP	Q8TCY5	MC5R	Homo sapiens	P33032	Anti Tag CoIP	19329486
Intra	MRAP	Q8TCY5	MC3R	Homo sapiens	P41968	Anti Tag CoIP	19329486
Intra	MRAP	Q8TCY5	MRAP	Homo sapiens	Q8TCY5	BiFC	20371771
Intra	MRAP	Q8TCY5	RPL15	Homo sapiens	P61313	Crosslink	30021884
Intra	MRAP	Q8TCY5	MRAP	Homo sapiens	Q8TCY5	Anti Tag CoIP	18077336

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MRAP Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74743	MRAP Protein, Human (HEK293, hFc)	Q8TCY5-4 (Y59-S172)	≥95%

Related Diseases

Diseases

Alias

Glucocorticoid Deficiency 2

GCCD2	Familial Glucocorticoid Deficiency 2
Fgd2

Glucocorticoid Deficiency 1

Acth Resistance	Glucocorticoid Deficiency, Due To Acth Unresponsiveness
GCCD1	Familial Glucocorticoid Deficiency 1
Fgd1	Adrenal Unresponsiveness To Acth
Hereditary Unresponsiveness To Adrenocorticotropic Hormone	Isolated Glucocorticoid Deficiency

Familial Glucocorticoid Deficiency

Glucocorticoid Deficiency	Acth Resistance
Adrenal Unresponsiveness To Acth	Hereditary Unresponsiveness To Adrenocorticotropic Hormone
Isolated Glucocorticoid Deficiency	Glucocorticoid Deficiency, Familial
Glucocorticoid Deficiency 1

Juvenile Ankylosing Spondylitis

Perforated Corneal Ulcer

Hypophosphatasia, Childhood

Childhood Hypophosphatasia	Childhood-Onset Hypophosphatasia
HPPC	Childhood-Onset Phosphoethanolaminuria
Childhood-Onset Rathburn Disease	Childhood-Onset Rathbun Disease

Iridocyclitis

Primary Iridocyclitis

Lipoid Congenital Adrenal Hyperplasia

Congenital Adrenal Hyperplasia	Congenital Lipoid Adrenal Hyperplasia Due To Star Deficency
Congenital Lipoid Adrenal Hyperplasia	Lipoid Cah
Lipoid Adrenal Hyperplasia	Adrenal Hyperplasia 1
Cah	Clah
LCAH	Adrenal Hyperplasia I
Lipoid Hyperplasia, Congenital, Of Adrenal Cortex With Male Pseudohermaphroditism	Congenital Adrenal Hyperplasia Lipoid
Adrenal Hyperplasia, Congenital	Congenital Adrenal Hyperplasia, Lipoid
AH1	Congenital Lipoid Hyperplasia Of Adrenal Cortex With Male Pseudohermaphroditism
Adrenal Hyperplasia Congenital	Hyperplasia, Adrenal, Lipoid, Congenital
Congenital Adrenogenital Disorders Associated With Enzyme Deficiency	Congenital Adrenal Cortical Hyperplasia
Congenital Adrenal Gland Hyperplasia	Congenital Adrenogenital Syndrome
Congenital Hyperadrenocorticism	Congenital Adrenogenitalism
Congenital Female Adrenal Pseudohermaphroditism

Glaucomatocyclitic Crisis

Posner-Schlossman Syndrome

Terrien-Viel Syndrome

Achalasia-Addisonianism-Alacrima Syndrome

Allgrove Syndrome	Triple-A Syndrome
Achalasia-Addisonianism-Alacrimia Syndrome	Alacrima-Achalasia-Adrenal Insufficiency Neurologic Disorder
Triple A Syndrome	Aaa Syndrome
AAAS	Glucocorticoid Deficiency With Achalasia
Glucocorticoid Deficiency And Achalasia	Addisonian-Achalasia Syndrome
Hypoadrenalism With Achalasia	Alacrima-Achalasia-Addisonianism
Aaa	Acth-Resistant Adrenal Insufficiency, Achalasia And Alacrima
Achalasia Addisonianism Alacrimia Syndrome	Achalasia Alacrima Syndrome
Addisonian Achalasia Syndrome	Achalasia-Addisonian Syndrome
Achalasia-Alacrima Syndrome	2a Syndrome
3a Syndrome	4a Syndrome
Adrenal Insufficiency-Achalasia-Alacrima Syndrome	Double A Syndrome
Quaternary A Syndrome	Acth-Resistant Adrenal Insufficiency With Achalasia And Alacrima
Allgrove'S Syndrome	Adrenal Gland Hypofunction
Adrenal Cortical Hypofunction

Ciliary Dyskinesia, Primary, 26

Primary Ciliary Dyskinesia 26	CILD26
Primary Ciliary Dyskinesia 26 With Or Without Situs Inversus	Ciliary Dyskinesia, Primary, 26, With Or Without Situs Inversus
Dyskinesia, Ciliary, Primary, 26

Balanitis

Urethritis

Nonspecific Urethritis	Non-Gonococcal Urethritis
Nongonococcal Urethritis

Developmental And Epileptic Encephalopathy 53

DEE53	Epileptic Encephalopathy, Early Infantile, 53
Eiee53	Developmental And Epileptic Encephalopathy, 53
Early Infantile Epileptic Encephalopathy 53

Anterior Uveitis

Iridocyclitis	Uveitis, Anterior
Acute Anterior Uveitis	Uveokeratitis
Keratouveitis	Cyclitis
Intraocular Inflammation	Kerato-Uveitis
Keratoiritis	Iritis
Uveitis Nos	Uveal Inflammation
Anterior Chamber Cell

Spondyloarthropathy

Spondylarthropathies	Spondarthropathy
Spondylarthrosis	Spondyloarthropathy, Susceptibility To
Spondylarthritis

Reactive Arthritis

Postdysenteric Arthropathy	Reiter Disease
Pira	Reiter Syndrome
Reiters Syndrome	Arthritis, Reactive
Fiessinger Leroy Reiter Syndrome	Post-Bacterial Arthropathy
Reiter'S Disease	Post-Infectious Arthritis
Post-Infectious Reactive Arthropathy	Reiter'S Syndrome
Arthritis Urethritica	Fiessinger-Leroy Disease
Polyarthritis Enterica	Venereal Arthritis
Arthritis Reactive	Post-Dysenteric Arthropathy
Arthritis, Venereal

Optic Papillitis

Papillitis

Papilledema

Facial Hemiatrophy

Parry-Romberg Syndrome

Panuveitis

Diffuse Uveitis	Total Uveitis
Inflammation Of The Whole Uveal Tract

Spondyloarthropathy 1

Ankylosing Spondylitis	Spondyloarthropathy, Susceptibility To, 1
SPDA1	Marie-Strumpell Spondylitis
Bechterew Syndrome	Spa
Spondylarthritis Ankylopoietica	Reiter Syndrome
Ankylosing Spondylitis, Susceptibility To	Bekhterev Syndrome
Bekhterev'S Disease	Marie-Strumpell Disease
Axial Spondylarthritis	Bechterew Disease
Marie-Struempell Disease	Spondylitis Ankylopoietica
Spondyloarthritis	Spondyloarthritis Ankylopoietica
Spas	Ankylosing Spondylarthritis
Psoriatic Arthritis	Reactive Arthritis
Rheumatoid Spondylitis	Spondylitis Ankylosans
Spondylitis Ankylosing	Spondylitis, Ankylosing
Spondylarthropathies	Arthritis, Psoriatic
Arthritis, Reactive

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08638	MRAP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08639	MRAP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MRAP	VGNC	VGNC:56121
Rattus norvegicus	MRAP	RGD	RGD:1310648
Mus musculus	MRAP	MGD	MGI:1924287
Macaca mulatta	MRAP	VGNC	VGNC:74729
Bos taurus	MRAP	VGNC	VGNC:56234
Others	MRAP	NCBI

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