PROX1 - prospero homeobox 1 Gene

Homo sapiens

Gene ID: 5629 | Gene type: protein coding

About PROX1

Cytogenetic location: 1q32.3 Genomic coordinates (GRCh38): 1:213,983,151-214,041,510 (from NCBI)

This gene has 7 transcripts (splice variants), 210 orthologues and 1 paralogue. Biased expression in liver (RPKM 20.2), adrenal (RPKM 5.1) and 13 other tissues.

Summary

The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

PROX1 Products(2)

mRNA	Protein	Name
NM_001270616.2	NP_001257545.1	prospero homeobox protein 1
NM_002763.5	NP_002754.2	prospero homeobox protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IMP IMP: Inferred from mutant phenotype	18815287	GOA
enables DNA binding domain binding	IPI IPI: Inferred from physical interaction	15205472	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15143342	GOA
enables LBD domain binding	IPI IPI: Inferred from physical interaction	15143342	GOA
enables nuclear receptor binding	IPI IPI: Inferred from physical interaction	15143342	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15205472	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	19210544	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in brain development	IEP IEP: Inferred from expression pattern	8812486	GOA
involved in embryonic retina morphogenesis in camera-type eye	IEP IEP: Inferred from expression pattern	12692551	GOA
involved in hepatocyte differentiation	IEP IEP: Inferred from expression pattern	15232737	GOA
involved in kidney development	IEP IEP: Inferred from expression pattern	8812486	GOA
involved in lens development in camera-type eye	IEP IEP: Inferred from expression pattern	8812486	GOA
involved in lens fiber cell morphogenesis	IEP IEP: Inferred from expression pattern	11850194	GOA
involved in liver development	IEP IEP: Inferred from expression pattern	11789987	GOA
involved in lung development	IEP IEP: Inferred from expression pattern	8812486	GOA
involved in lymphangiogenesis	IDA IDA: Inferred from direct assay	12412020	GOA
involved in lymphatic endothelial cell differentiation	IDA IDA: Inferred from direct assay	12198161	GOA
involved in lymphatic endothelial cell fate commitment	IMP IMP: Inferred from mutant phenotype	18815287	GOA
involved in negative regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	15205472	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15143342	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	16488887	GOA
involved in negative regulation of bile acid biosynthetic process	IMP IMP: Inferred from mutant phenotype	16488887	GOA
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	17062673	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15205472	GOA
involved in negative regulation of viral genome replication	IDA IDA: Inferred from direct assay	19264593	GOA
involved in pancreas development	IEP IEP: Inferred from expression pattern	11789987	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	12198161	GOA
involved in positive regulation of cyclin-dependent protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	19210544	GOA
involved in positive regulation of endothelial cell migration	IDA IDA: Inferred from direct assay	19210544	GOA
involved in positive regulation of endothelial cell proliferation	IDA IDA: Inferred from direct assay	19210544	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18815287	GOA
involved in regulation of circadian rhythm	IMP IMP: Inferred from mutant phenotype	23723244	GOA
involved in regulation of gene expression	IDA IDA: Inferred from direct assay	12198161	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11850194	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11850194	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PROX1 Protein Structure

HPD

0
200
400
600
737 a.a.

Protein Preferred Names

Protein Names

prospero homeobox protein 1

homeobox prospero-like protein PROX1

PROX1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PROX1	Q92786	HNF1A	Homo sapiens	P20823	Anti Tag CoIP	19264593
Intra	PROX1	Q92786	HNF1A	Homo sapiens	P20823	Pull Down	19264593
Intra	PROX1	Q92786	CTBP2	Homo sapiens	P56545	Y2H	21988832
Intra	PROX1	Q92786	NR5A2	Homo sapiens	O00482-2	Pull Down	15205472
Intra	PROX1	Q92786	NR5A2	Homo sapiens	O00482-2	Anti Bait CoIP	15205472
Intra	PROX1	Q92786	NR5A2	Homo sapiens	O00482-2	Confocal	15205472
Intra	PROX1	Q92786	NR5A2	Homo sapiens	O00482-2	Y2H	15205472
Intra	PROX1	Q92786	NR5A2	Homo sapiens	O00482-2	Gal4 VP16 Complement	15205472

Cross: Cross-species interaction Intra: Intraspecies interaction

PROX1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82009	PROX1 Antibody (YA1754)	WB	Rat

Related Diseases

Diseases

Alias

Generalized Lymphatic Anomaly

Doid:0081031

Hereditary Lymphedema I

Lymphedema	Hereditary Lymphedema Type I
Congenital Primary Lymphedema	Lmph1
Milroy Disease	Nonne-Milroy Lymphedema
Pcl	Lymphedema Hereditary Type 1

Lymphangioma

Lymphatic Malformation	Lymphatic Malformations
Benign Lymphangioma	Congenital Lymphangioma
Lymphangiomas

Angiokeratoma Of Fordyce

Fordyce Angiokeratoma	Fordyce'S Spot
Fordyce-Type Angiokeratoma Of Scrotum

Acquired Hemangioma

Malignant Ciliary Body Melanoma

Malignant Melanoma Of Ciliary Body

Melanoma Of The Ciliary Body

Ciliary Body Cancer

Malignant Neoplasm Of Ciliary Body	Malignant Tumor Of Ciliary Body
Malignant Tumor Of The Ciliary Body	Neoplasm Of Ciliary Body
Tumor Of The Ciliary Body	Primary Malignant Neoplasm Of Ciliary Body
Malignant Neoplasm Of Eyeball	Malignant Neoplasm Of Uveal Tract
Primary Malignant Neoplasm Of Sclera	Primary Malignant Neoplasm Of Uveal Tract

Hemangioma

Hemangiomas

Lymphangiosarcoma

Skin Lymphangiosarcoma	Stewart Treves Syndrome
Lymphangiosarcoma Of Stewart And Treves	Malignant Lymphangioendothelioma
Stewart-Treves Syndrome

Capillary Lymphangioma

Microcystic Lymphatic Malformation	Capillary Lymphatic Malformation
Microcystic Infiltrating Lymphatic Malformation	Microcystic Lymphangioma
Superficial Lymphangioma	Cutaneous Lymphangioma Circumscriptum
Superficial Lymphatic Malformation	Cutaneous Lymphangioma
Lymphangioma Of Skin	Lymphangioma Circumscriptum

Hypotrichosis-Lymphedema-Telangiectasia Syndrome

HLTS	Hypotrichosis Lymphedema Telangiectasia Syndrome
Hypotrichosis-Lymphedema-Telangiectasia-Membranoproliferative Glomerulonephritis Syndrome	Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome

Spindle Cell Hemangioma

Sch	Spindle Cell Hemangioendothelioma

Inflammatory Breast Carcinoma

Inflammatory Breast Cancer	Inflammatory Carcinoma Of Breast
Mastitis Carcinomatosa	Breast Cancer, Inflammatory
Inflammatory Breast Neoplasms	Inflammatory Adenocarcinoma Of Breast

Gorham'S Disease

Gorham-Stout Syndrome	Osteolysis, Essential
Disappearing Bone Disease	Essential Osteolysis
Gorham Disease	Massive Osteolysis
Phantom Bone Disease	Cystic Angiomatosis Of Bone Diffuse
Gorham-Stout Disease	Osteolysis Massive
Vanishing Bone Disease	Massive Osteolyses

Hereditary Lymphedema

Milroy Disease

Mucocele Of Salivary Gland

Ranula	Salivary Cyst
Salivary Gland Mucocele	Mucous Retention Cyst Of Salivary Gland
Retention Cyst Of Salivary Gland	Sialocele
Cyst Of Salivary Gland Or Duct	Extravasation Cyst Of Salivary Gland

Cystic Lymphangioma

Cystic Hygroma	Cavernous Lymphangioma
Macrocystic Lymphatic Malformation	Cavernous Lymphatic Malformation
Macrocystic Lymphangioma	Lymphangioma, Cystic

Lymphedema-Distichiasis Syndrome

Lymphedema With Distichiasis	Lymphedema-Distichiasis Syndrome With Renal Disease And Diabetes Mellitus
LPHDST	Distichiasis-Lymphedema Syndrome
Lymphedema Distichiasis Syndrome	Hereditary Lymphedema-Distichiasis Syndrome
Lymphedema Distichiasis

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Capillary Hemangioma

Infantile Hemangioma	Strawberry Nevus Of Skin
Cellular Hemangioma Of Infancy	Congenital Vascular Hamartoma
Congenital Vascular Naevus	Juvenile Hemangioma
Strawberry Haemangioma	Strawberry Nevus
Hemangioma Capillary	Hemangioma, Capillary
Hemangioma, Cavernous

Cerebral Cavernous Malformations

Cerebral Cavernous Malformation	Cavernous Malformations Of Cns And Retina
Cerebral Cavernous Malformation 1	Cavernous Angiomatous Malformations
Cerebral Capillary Malformations	CCM
Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations	Familial Cavernous Angioma
Cavernous Angioma	Familial Cerebral Cavernous Malformation
Cerebral Cavernous Malformations 1	Cavernous Angioma, Familial
Cam	Cerebral Cavernous Malformations-1
Cavernoma	Central Nervous System Cavernous Hemangioma
Cerebral Cavernous Hemangioma	Familial Cavernous Hemangioma
Familial Cavernous Malformation	Familial Cerebral Cavernous Angioma
Intracerebral Cavernous Hemangioma	CCM1
Cavernous Hemangioma Of The Brain	Cerebral Cavernoma
Cerebral Cavernous Malformations, Type 1	Hemangioma, Cavernous, Central Nervous System
Hemangioma, Cavernous	Angioma, Cavernous

Hennekam Syndrome

Hennekam Lymphangiectasia Lymphedema Syndrome	Hennekam Lymphangiectasia-Lymphedema Syndrome
Lymphedema-Lymphangiectasia-Intellectual Disability Syndrome	Lymphedem-Lymphangiectasia-Intellectual Disability Syndrome
Intestinal Lymphagiectasia Lymphedema Intellectual Deficit Syndrome	Lymphangiectasies And Lymphedema Hennekam Type
Generalized Lymphatic Dysplasia	Intestinal Lymphagiectasia-Lymphedema-Mental Retardation Syndrome

Klippel-Trenaunay-Weber Syndrome

Klippel-Trenaunay Syndrome	KTS
Ktw Syndrome	Angioosteohypertrophy Syndrome
Angio-Osteohypertrophy Syndrome	Klippel Trenaunay Syndrome
Klippel-Trénaunay-Weber Syndrome	Haemangiectatic Hypertrophy
Weber-Klippel-Trenaunay	Congenital Dysplastic Angiopathy
Klippel-Trenaunay Disease	Weber Klippel Trenaunay

Maturity-Onset Diabetes Of The Young

MODY	Maturity Onset Diabetes Mellitus In Young
Mason-Type Diabetes	Mason Type Diabetes
Maturity Onset Diabetes Of The Young	Mody Syndrome
Diabetes Of The Young, Maturity-Onset

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11203	PROX1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PROX1	VGNC	VGNC:76427
Mus musculus	PROX1	MGD	MGI:97772
Canis familiaris	PROX1	VGNC	VGNC:45017
Felis catus	PROX1	VGNC	VGNC:69080
Bos taurus	PROX1	VGNC	VGNC:33369
Rattus norvegicus	PROX1	RGD	RGD:1306890

Name
Email *

	Sorry, but the email address you supplied was invalid.