Arl3 - ADP-ribosylation factor-like 3 Gene

Mus musculus

Gene ID: 56350 | Gene type: protein coding

About Arl3

Summary

Enables several functions, including GTPase activating protein binding activity; guanyl ribonucleotide binding activity; and magnesium ion binding activity. Involved in several processes, including Golgi to plasma membrane transport; photoreceptor cell development; and protein localization to ciliary membrane. Acts upstream of or within intraciliary transport and smoothened signaling pathway. Located in axoneme; ciliary basal body; and ciliary transition zone. Is expressed in central nervous system; hippocampus; retina inner nuclear layer; and retina outer nuclear layer. Used to study autosomal recessive polycystic kidney disease and retinitis pigmentosa 2. Human ortholog(s) of this gene implicated in Joubert syndrome and retinitis pigmentosa 83. Orthologous to human ARL3 (ADP ribosylation factor like GTPase 3). [provided by Alliance of Genome Resources, Apr 2022]

Arl3 Products(2)

mRNA	Protein	Name
NM_001355233.1	NP_001342162.1	ADP-ribosylation factor-like protein 3 isoform 2
NM_019718.3	NP_062692.1	ADP-ribosylation factor-like protein 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GDP binding	IDA IDA: Inferred from direct assay	15979089	MGI
enables GTP binding	IDA IDA: Inferred from direct assay	10518933	MGI
enables GTPase activity	IDA IDA: Inferred from direct assay	10518933	MGI
enables magnesium ion binding	IDA IDA: Inferred from direct assay	26455799	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10518933	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in Golgi to plasma membrane transport	IMP IMP: Inferred from mutant phenotype	25405894	MGI
acts upstream of or within intraciliary transport	IMP IMP: Inferred from mutant phenotype	21289087	MGI
involved in kidney development	IMP IMP: Inferred from mutant phenotype	16565502	MGI
involved in photoreceptor cell development	IMP IMP: Inferred from mutant phenotype	16565502	MGI
involved in protein localization to ciliary membrane	IMP IMP: Inferred from mutant phenotype	25405894	MGI
acts upstream of or within smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	21289087	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in axoneme	IDA IDA: Inferred from direct assay	26455799	MGI
located in ciliary basal body	IDA IDA: Inferred from direct assay	26455799	MGI
located in ciliary transition zone	IDA IDA: Inferred from direct assay	26455799	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ADP-ribosylation factor-like protein 3

ADP-ribosylation-like 3

Arl3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Arl3	Q9WUL7	Cfap36	Mus musculus	Q8C6E0	X-Ray Diffraction	26455799
Intra	Arl3	Q9WUL7	Cfap36	Mus musculus	Q8C6E0	GMS	26455799
Intra	Arl3	Q9WUL7	Cfap36	Mus musculus	Q8C6E0	Pull Down	26455799
Intra	Arl3	Q9WUL7	Cfap36	Mus musculus	Q8C6E0	FPS	26455799
Cross	Arl3	Q9WUL7	CFAP36	Homo sapiens	Q96G28	GMS	26455799
Cross	Arl3	Q9WUL7	CFAP36	Homo sapiens	Q96G28	FPS	26455799
Cross	Arl3	Q9WUL7	UNC119	Homo sapiens	Q13432	FPS	22960633
Cross	Arl3	Q9WUL7	PDE6D	Homo sapiens	O43924	Pull Down	23559067
Cross	Arl3	Q9WUL7	PDE6D	Homo sapiens	O43924	GMS	23559067
Cross	Arl3	Q9WUL7	RP2	Homo sapiens	O75695	Enzymatic Study	18376416

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00987	ARL3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Arl3	NCBI	NCBI:403

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