ERO1B - endoplasmic reticulum oxidoreductase 1 beta Gene

Homo sapiens

Also known as ERO1LB; Ero1beta

Gene ID: 56605 | Gene type: protein coding

About ERO1B

Cytogenetic location: 1q42.3 Genomic coordinates (GRCh38): 1:236,215,101-236,281,958 (from NCBI)

This gene has 12 transcripts (splice variants), 205 orthologues and 1 paralogue. Broad expression in stomach (RPKM 19.2), thyroid (RPKM 16.8) and 25 other tissues.

Summary

Enables thiol oxidase activity. Involved in protein folding in endoplasmic reticulum. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]

ERO1B Products(1)

mRNA	Protein	Name
NM_019891.4	NP_063944.3	ERO1-like protein beta precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20802462	GOA
enables protein-disulfide reductase activity	EXP EXP: Inferred from Experiment	11707400	GOA
enables thiol oxidase activity	IDA IDA: Inferred from direct assay	21091435	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein folding in endoplasmic reticulum	IDA IDA: Inferred from direct assay	21091435	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ERO1B Protein Structure

ERO1

0
100
200
300
400
467 a.a.

Protein Preferred Names

Protein Names

ERO1-like protein beta

ERO1-L-beta

ERO1B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ERO1B	Q86YB8	PDIA3	Homo sapiens	P30101	Anti Tag CoIP	20802462

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hypoascorbemia

Scurvy	Ascorbic Acid Deficiency
Vitamin C Deficiency	Vitamin C, Inability To Synthesize
Deficiency Of Vitamin C	Scorbutus
Vitamin C

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04512	ERO1B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ERO1B	VGNC	VGNC:40467
Rattus norvegicus	ERO1B	RGD	RGD:1563548
Macaca mulatta	ERO1B	VGNC	VGNC:99911
Felis catus	ERO1B	VGNC	VGNC:61955
Mus musculus	ERO1B	MGD	MGI:1914725
Bos taurus	ERO1B	VGNC	VGNC:28595

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