Gsk3b - glycogen synthase kinase 3 beta Gene

Mus musculus

Also known as GSK3; GSK-3; GSK-3beta; 7330414F15Rik; 8430431H08Rik

Gene ID: 56637 | Gene type: protein coding

About Gsk3b

Summary

Enables several functions, including beta-catenin binding activity; dynein complex binding activity; and protein kinase activity. Involved in several processes, including apoptotic signaling pathway; negative regulation of signal transduction; and regulation of gene expression. Acts upstream of or within several processes, including cellular response to hepatocyte growth factor stimulus; positive regulation of nitrogen compound metabolic process; and regulation of neuron projection development. Located in several cellular components, including dendritic shaft; glutamatergic synapse; and postsynaptic density. Part of Wnt signalosome; beta-catenin destruction complex; and ribonucleoprotein complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyotrophic lateral sclerosis; bipolar disorder; and schizophrenia. Orthologous to human GSK3B (glycogen synthase kinase 3 beta). [provided by Alliance of Genome Resources, Apr 2022]

Gsk3b Products(2)

mRNA	Protein	Name
NM_001347232.1	NP_001334161.1	glycogen synthase kinase-3 beta isoform 2
NM_019827.7	NP_062801.1	glycogen synthase kinase-3 beta isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables beta-catenin binding	IPI IPI: Inferred from physical interaction	12874278	MGI
enables dynein complex binding	IPI IPI: Inferred from physical interaction	28057765	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9554852	MGI
enables protein kinase activity	IDA IDA: Inferred from direct assay	14730361	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	22899650	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	12805290	MGI
enables protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	16543145	MGI
enables tau-protein kinase activity	IDA IDA: Inferred from direct assay	15192701	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within ER overload response	IDA IDA: Inferred from direct assay	14744935	MGI
acts upstream of or within Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	23074275	MGI
acts upstream of or within animal organ morphogenesis	IMP IMP: Inferred from mutant phenotype	10894547	MGI
acts upstream of positive effect autosome genomic imprinting	IMP IMP: Inferred from mutant phenotype	21047779	MGI
acts upstream of axon extension	IGI IGI: Inferred from genetic interaction	24623780	MGI
acts upstream of or within axonogenesis	IGI IGI: Inferred from genetic interaction	18716223	MGI
acts upstream of or within canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	15282335	MGI
acts upstream of or within canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	16815997	MGI
acts upstream of or within cell migration	IGI IGI: Inferred from genetic interaction	17986005	MGI
involved in cellular response to glucocorticoid stimulus	IGI IGI: Inferred from genetic interaction	20371704	MGI
acts upstream of or within cellular response to hepatocyte growth factor stimulus	IDA IDA: Inferred from direct assay	21072211	MGI
involved in cellular response to interleukin-3	IDA IDA: Inferred from direct assay	16543145	MGI
involved in circadian rhythm	IMP IMP: Inferred from mutant phenotype	20123978	MGI
involved in extrinsic apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	20371704	MGI
involved in extrinsic apoptotic signaling pathway in absence of ligand	IDA IDA: Inferred from direct assay	16543145	MGI
acts upstream of or within fat cell differentiation	IDA IDA: Inferred from direct assay	12502791	MGI
involved in insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	28057765	MGI
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	23028846	MGI
involved in meiosis I	IMP IMP: Inferred from mutant phenotype	29228573	MGI
acts upstream of or within myoblast fusion	IDA IDA: Inferred from direct assay	15282335	MGI
acts upstream of or within myoblast fusion	IGI IGI: Inferred from genetic interaction	15282335	MGI
acts upstream of or within myotube differentiation	IGI IGI: Inferred from genetic interaction	15282335	MGI
involved in negative regulation of TOR signaling	IGI IGI: Inferred from genetic interaction	26160071	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	10894547	MGI
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	12154096	MGI
acts upstream of or within negative regulation of cardiac muscle hypertrophy	IDA IDA: Inferred from direct assay	11782539	MGI
involved in negative regulation of glycogen biosynthetic process	IMP IMP: Inferred from mutant phenotype	31553910	MGI
acts upstream of or within negative regulation of neuron maturation	IGI IGI: Inferred from genetic interaction	23015435	MGI
acts upstream of or within negative regulation of neuron projection development	IGI IGI: Inferred from genetic interaction	23015435	MGI
acts upstream of or within negative regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	23015435	MGI
involved in negative regulation of protein localization to centrosome	IMP IMP: Inferred from mutant phenotype	28057765	MGI
acts upstream of or within peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	17986005	MGI
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	20123978	MGI
involved in peptidyl-serine phosphorylation	IGI IGI: Inferred from genetic interaction	16537926	MGI
involved in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	29228573	MGI
involved in phosphorylation	IMP IMP: Inferred from mutant phenotype	17182001	MGI
involved in positive regulation of autophagy	IDA IDA: Inferred from direct assay	22539723	MGI
involved in positive regulation of autophagy	IGI IGI: Inferred from genetic interaction	26160071	MGI
acts upstream of or within positive regulation of axon extension	IGI IGI: Inferred from genetic interaction	24623780	MGI
involved in positive regulation of cardiac muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	24974728	MGI
involved in positive regulation of cilium assembly	IMP IMP: Inferred from mutant phenotype	25860027	MGI
involved in positive regulation of gene expression	IGI IGI: Inferred from genetic interaction	20371704	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	24974728	MGI
involved in positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	IDA IDA: Inferred from direct assay	16543145	MGI
acts upstream of or within positive regulation of peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	17986005	MGI
acts upstream of or within positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IGI IGI: Inferred from genetic interaction	22660580	MGI
acts upstream of or within positive regulation of protein binding	IDA IDA: Inferred from direct assay	19141611	MGI
involved in positive regulation of protein localization to cilium	IMP IMP: Inferred from mutant phenotype	25860027	MGI
acts upstream of or within positive regulation of stem cell differentiation	IMP IMP: Inferred from mutant phenotype	22064483	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	23015435	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	21047779	MGI
acts upstream of or within protein export from nucleus	IDA IDA: Inferred from direct assay	11782539	MGI
acts upstream of or within protein localization to microtubule	IGI IGI: Inferred from genetic interaction	18716223	MGI
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	12432063	MGI
acts upstream of or within protein phosphorylation	IGI IGI: Inferred from genetic interaction	19141611	MGI
involved in protein phosphorylation	IMP IMP: Inferred from mutant phenotype	16543145	MGI
acts upstream of or within re-entry into mitotic cell cycle	IDA IDA: Inferred from direct assay	12502791	MGI
involved in regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	12154096	MGI
acts upstream of or within regulation of cell growth	IMP IMP: Inferred from mutant phenotype	18824542	MGI
involved in regulation of circadian rhythm	IMP IMP: Inferred from mutant phenotype	28556462	MGI
involved in regulation of long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	28556462	MGI
involved in regulation of microtubule-based process	IDA IDA: Inferred from direct assay	21295697	MGI
acts upstream of or within regulation of neuron projection development	IGI IGI: Inferred from genetic interaction	24227739	MGI
acts upstream of stem cell differentiation	IMP IMP: Inferred from mutant phenotype	22064483	MGI
acts upstream of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	23015435	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of Wnt signalosome	IDA IDA: Inferred from direct assay	22899650	MGI
part of beta-catenin destruction complex	IDA IDA: Inferred from direct assay	10318824	MGI
located in cytosol	IDA IDA: Inferred from direct assay	12502791	MGI
located in dendritic shaft	IDA IDA: Inferred from direct assay	12805290	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	20111716	MGI
located in growth cone	IDA IDA: Inferred from direct assay	12805290	MGI
is active in meiotic spindle	IDA IDA: Inferred from direct assay	29228573	MGI
located in membrane-bounded organelle	IDA IDA: Inferred from direct assay	12805290	MGI
located in neuronal cell body	IDA IDA: Inferred from direct assay	12805290	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12502791	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	20890042	MGI
is active in postsynaptic density	IDA IDA: Inferred from direct assay	20111716	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	17114649	MGI
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	21709260	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

glycogen synthase kinase-3 beta

serine/threonine-protein kinase GSK3B

Gsk3b Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Gsk3b	Q9WV60	Epm2a	Mus musculus	Q9WUA5	Anti Bait CoIP	16959610
Intra	Gsk3b	Q9WV60	Ctnnb1	Mus musculus	Q02248	Protein Kinase Assay	19107203

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Gsk3b Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73090	GSK-3 beta Protein, Mouse (sf9, His)	Q9WV60 (M1-T420)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112388	GSK-3b Inhibitor XI	Inhibitor	99.10%	Unkown
HY-RS05865	GSK3B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gsk3b	NCBI	NCBI:2932

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