1. Gene
  2. GSK3B - glycogen synthase kinase 3 beta Gene

GSK3B - glycogen synthase kinase 3 beta Gene

Homo sapiens
Gene ID: 2932 | Gene type: protein coding

About GSK3B

Cytogenetic location: 3q13.33 Genomic coordinates (GRCh38): 3:119,821,321-120,094,447 (from NCBI)

This gene has 69 transcripts (splice variants), 228 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 13.9), thyroid (RPKM 9.9) and 25 other tissues.

Summary

The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease. [provided by RefSeq, Aug 2017]

GSK3B Products(6)

mRNA Protein Name
NM_001146156.2 NP_001139628.1 glycogen synthase kinase-3 beta isoform 2
NM_001354596.2 NP_001341525.1 glycogen synthase kinase-3 beta isoform 3
NM_002093.4 NP_002084.2 glycogen synthase kinase-3 beta isoform 1
NM_001146156.2 NP_001139628.1 glycogen synthase kinase-3 beta isoform 2
NM_001354596.2 NP_001341525.1 glycogen synthase kinase-3 beta isoform 3
NM_002093.4 NP_002084.2 glycogen synthase kinase-3 beta isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables NF-kappaB binding IPI
IPI: Inferred from physical interaction
15465828 GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
20864106 GOA
enables beta-catenin binding IPI
IPI: Inferred from physical interaction
8638126 GOA
enables dynactin binding IPI
IPI: Inferred from physical interaction
17139249 GOA
enables kinase activity IDA
IDA: Inferred from direct assay
15448698 GOA
enables p53 binding IDA
IDA: Inferred from direct assay
14744935 GOA
enables protease binding IPI
IPI: Inferred from physical interaction
25118933 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
8638126 GOA
enables protein kinase A catalytic subunit binding IPI
IPI: Inferred from physical interaction
11035810 GOA
enables protein kinase activity IMP
IMP: Inferred from mutant phenotype
16981698 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
18348280 GOA
enables protein serine kinase activity IGI
IGI: Inferred from genetic interaction
30556160 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
8638126 GOA
enables protein serine/threonine kinase activity IMP
IMP: Inferred from mutant phenotype
16981698 GOA
enables tau-protein kinase activity IDA
IDA: Inferred from direct assay
14690523 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
21118991 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within ER overload response IDA
IDA: Inferred from direct assay
14744935 GOA
involved in canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
10428961 GOA
involved in cellular response to retinoic acid IMP
IMP: Inferred from mutant phenotype
28122350 GOA
involved in epithelial to mesenchymal transition IMP
IMP: Inferred from mutant phenotype
15448698 GOA
involved in glycogen metabolic process IDA
IDA: Inferred from direct assay
8638126 GOA
involved in hippocampus development IMP
IMP: Inferred from mutant phenotype
19581563 GOA
acts upstream of or within intracellular signal transduction IDA
IDA: Inferred from direct assay
14749367 GOA
involved in mitochondrion organization IMP
IMP: Inferred from mutant phenotype
25118933 GOA
acts upstream of or within negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
14744935 GOA
involved in negative regulation of calcineurin-NFAT signaling cascade IMP
IMP: Inferred from mutant phenotype
9072970 GOA
involved in negative regulation of canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
27846906 GOA
involved in negative regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
24023731 GOA
involved in negative regulation of cell migration IDA
IDA: Inferred from direct assay
27494834 GOA
involved in negative regulation of epithelial to mesenchymal transition IDA
IDA: Inferred from direct assay
15448698 GOA
involved in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IMP
IMP: Inferred from mutant phenotype
18846110 GOA
acts upstream of negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
27050373 GOA
involved in negative regulation of mesenchymal stem cell differentiation IMP
IMP: Inferred from mutant phenotype
24023731 GOA
involved in negative regulation of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
24023731 GOA
involved in negative regulation of protein-containing complex assembly IMP
IMP: Inferred from mutant phenotype
16188939 GOA
involved in neuron projection development IDA
IDA: Inferred from direct assay
19830702 GOA
acts upstream of or within peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
11104755 GOA
involved in peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
8638126 GOA
involved in peptidyl-serine phosphorylation IGI
IGI: Inferred from genetic interaction
30556160 GOA
involved in peptidyl-threonine phosphorylation IDA
IDA: Inferred from direct assay
11955436 GOA
involved in positive regulation of GTPase activity IMP
IMP: Inferred from mutant phenotype
18156211 GOA
involved in positive regulation of cell differentiation IMP
IMP: Inferred from mutant phenotype
28122350 GOA
involved in positive regulation of cell-matrix adhesion IMP
IMP: Inferred from mutant phenotype
18156211 GOA
acts upstream of positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
26315788 GOA
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
19364825 GOA
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
25897075 GOA
acts upstream of or within positive regulation of protein export from nucleus IDA
IDA: Inferred from direct assay
14744935 GOA
involved in positive regulation of protein localization to centrosome IMP
IMP: Inferred from mutant phenotype
17139249 GOA
involved in positive regulation of protein ubiquitination IDA
IDA: Inferred from direct assay
29142209 GOA
involved in positive regulation of protein-containing complex assembly IDA
IDA: Inferred from direct assay
8638126 GOA
involved in presynaptic modulation of chemical synaptic transmission EXP
EXP: Inferred from Experiment
17989287 GOA
involved in presynaptic modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
17989287 GOA
involved in presynaptic modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
17989287 GOA
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
23184662 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
11035810 GOA
involved in protein phosphorylation IMP
IMP: Inferred from mutant phenotype
16981698 GOA
involved in regulation of microtubule anchoring at centrosome IMP
IMP: Inferred from mutant phenotype
17139249 GOA
involved in regulation of microtubule-based process IMP
IMP: Inferred from mutant phenotype
20937854 GOA
involved in regulation of protein export from nucleus IDA
IDA: Inferred from direct assay
12223487 GOA
involved in superior temporal gyrus development IMP
IMP: Inferred from mutant phenotype
19581563 GOA
Cellular Component GO Annotation Evidence Reference Source
part of beta-catenin destruction complex IDA
IDA: Inferred from direct assay
8638126 GOA
located in centrosome IDA
IDA: Inferred from direct assay
17139249 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
12223487 GOA
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
17989287 GOA
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
17989287 GOA
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
17989287 GOA
located in nucleus IDA
IDA: Inferred from direct assay
12223487 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
20937854 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GSK3B Protein Structure

STKc_GSK3

STKc_GSK3: cd14137 (50 - 342)

  • 0
  • 100
  • 200
  • 300
  • 420 a.a.
Protein Preferred Names Protein Names

glycogen synthase kinase-3 beta

GSK-3 beta

GSK3B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
GSK3B P49841 SNAI1 Homo sapiens O95863
Anti Bait CoIP
19411070
Intra
GSK3B P49841 CABYR Homo sapiens O75952-5
Protein Kinase Assay
15752768
Intra
GSK3B P49841 CABYR Homo sapiens O75952-5
Pull Down
15752768
Intra
GSK3B P49841 CABYR Homo sapiens O75952-5
Y2H
15752768
Intra
GSK3B P49841 CABYR Homo sapiens O75952-3
Y2H
15752768
Intra
GSK3B P49841 CABYR Homo sapiens O75952-3
Pull Down
15752768
Intra
GSK3B P49841 CABYR Homo sapiens O75952-3
Protein Kinase Assay
15752768
Intra
GSK3B P49841 BICD1 Homo sapiens Q96G01
Anti Tag CoIP
17139249
Intra
GSK3B P49841 BICD1 Homo sapiens Q96G01
Pull Down
17139249
Cross
GSK3B P49841 Disc1 Mus musculus Q811T9
SPR
19303846
Cross
GSK3B P49841 Disc1 Mus musculus Q811T9
Protein Kinase Assay
19303846
Intra
GSK3B P49841 AKT2 Homo sapiens P31751
X-Ray Diffraction
12434148
Intra
GSK3B P49841 AKT1 Homo sapiens P31749
Anti Tag CoIP
23010592
Intra
GSK3B P49841 RELB Homo sapiens Q01201
Anti Bait CoIP
21217772
Intra
GSK3B P49841 UBR5 Homo sapiens O95071
Pull Down
21118991
Intra
GSK3B P49841 UBR5 Homo sapiens O95071
Anti Tag CoIP
21118991
Intra
GSK3B P49841 UBR5 Homo sapiens O95071
Confocal
21118991
Intra
GSK3B P49841 UBR5 Homo sapiens O95071
Anti Bait CoIP
21118991
Intra
GSK3B P49841 TP53 Homo sapiens P04637
Protein Kinase Assay
14744935
Intra
GSK3B P49841 TP53 Homo sapiens P04637
Anti Bait CoIP
14744935
Intra
GSK3B P49841 MAPT Homo sapiens P10636-8
Protein Kinase Assay
24165324
Intra
GSK3B P49841 MAPT Homo sapiens P10636-8
Anti Tag CoIP
24165324
Intra
GSK3B P49841 MAPT Homo sapiens P10636-8
Protein Kinase Assay
21985244
Intra
GSK3B P49841 FRAT1 Homo sapiens Q92837
Protein Kinase Assay
10481074
Intra
GSK3B P49841 FRAT1 Homo sapiens Q92837
TAP
23602568
Intra
GSK3B P49841 FRAT1 Homo sapiens Q92837
Pull Down
29568061
Intra
GSK3B P49841 FRAT1 Homo sapiens Q92837
TAP
23455922
Intra
GSK3B P49841 ZFPM1 Homo sapiens Q8IX07
Y2H
21988832
Intra
GSK3B P49841 DACT1 Homo sapiens Q9NYF0
Confocal
22470507
Cross
GSK3B P49841 Mapk1 Mus musculus P63085
Protein Kinase Assay
18045539
Cross
GSK3B P49841 Ctnnb1 Mus musculus Q02248
Protein Kinase Assay
10481074
Cross
GSK3B P49841 Ctnnb1 Mus musculus Q02248
Protein Kinase Assay
12421363
Cross
GSK3B P49841 Axin1 Mus musculus Q14DJ8
Anti Tag CoIP
21242974
Cross
GSK3B P49841 Axin1 Mus musculus Q14DJ8
Pull Down
21242974
Intra
GSK3B P49841 AXIN2 Homo sapiens Q9Y2T1
Pull Down
29568061
Intra
GSK3B P49841 AXIN2 Homo sapiens Q9Y2T1
TAP
23602568
Intra
GSK3B P49841 AXIN2 Homo sapiens Q9Y2T1
TAP
23455922
Intra
GSK3B P49841 AXIN2 Homo sapiens Q9Y2T1
Pull Down
32707033
Intra
GSK3B P49841 EIF2B5 Homo sapiens Q13144
Protein Kinase Assay
10481074
Intra
GSK3B P49841 PRKACA Homo sapiens P17612
Anti Tag CoIP
11035810
Intra
GSK3B P49841 PRKACA Homo sapiens P17612
BioID
29568061
Intra
GSK3B P49841 PRKACA Homo sapiens P17612
TAP
23602568
Intra
GSK3B P49841 PRKACA Homo sapiens P17612
Pull Down
29568061
Intra
GSK3B P49841 CTNNB1 Homo sapiens P35222
BioID
29568061
Intra
GSK3B P49841 CTNNB1 Homo sapiens P35222
PLA
25241761
Intra
GSK3B P49841 CTNNB1 Homo sapiens P35222
Anti Bait CoIP
18687691
Intra
GSK3B P49841 CTNNB1 Homo sapiens P35222
TAP
23602568
Intra
GSK3B P49841 CTNNB1 Homo sapiens P35222
Anti Bait CoIP
8638126
Intra
GSK3B P49841 CTNNB1 Homo sapiens P35222
Anti Tag CoIP
8638126
Intra
GSK3B P49841 CTNNB1 Homo sapiens P35222
Protein Kinase Assay
19303846
Intra
GSK3B P49841 LRRK2 Homo sapiens Q5S007
Protein Kinase Assay
24165324
Intra
GSK3B P49841 LRRK2 Homo sapiens Q5S007
Anti Bait CoIP
24165324
Intra
GSK3B P49841 LRRK2 Homo sapiens Q5S007
Anti Tag CoIP
24165324
Intra
GSK3B P49841 STYK1 Homo sapiens Q6J9G0
Anti Tag CoIP
23010592
Intra
GSK3B P49841 TRIM29 Homo sapiens Q14134
Anti Bait CoIP
19249679
Intra
GSK3B P49841 GYS1 Homo sapiens P13807
Protein Kinase Assay
24165324
Intra
GSK3B P49841 GYS1 Homo sapiens P13807
Protein Kinase Assay
16282323
Intra
GSK3B P49841 GYS1 Homo sapiens P13807
Protein Kinase Assay
10481074
Intra
GSK3B P49841 NBR1 Homo sapiens Q14596
Protein Kinase Assay
24879152
Intra
GSK3B P49841 NBR1 Homo sapiens Q14596
Pull Down
24879152
Intra
GSK3B P49841 NBR1 Homo sapiens Q14596
BioID
29568061
Intra
GSK3B P49841 LRP6 Homo sapiens O75581
Anti Tag CoIP
16365045
Intra
GSK3B P49841 DAB2IP Homo sapiens Q5VWQ8-2
Anti Bait CoIP
20080667
Intra
GSK3B P49841 DAB2IP Homo sapiens Q5VWQ8-2
Anti Tag CoIP
20080667
Intra
GSK3B P49841 SNCA Homo sapiens P37840
Pull Down
21985244
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GSK3B Proteins

Cat. No. Product Name Accession Purity
HY-P74114 GSK-3 beta Protein, Human (sf9, His) P49841-2/NP_002084.2 (M1-T433) ≥95%
HY-P700591 GSK-3 beta Protein, Human (P. pastoris, His) P49841-1 (M1-T420) ≥95%

GSK3B Antibodies

Cat. No. Product Name Application Reactivity
HY-P80698 GSK3 beta Antibody (YA744) WB, IHC-P, FC Human, Mouse, Rat
HY-P80819 Phospho-GSK3 (Tyr216/Tyr279) Antibody WB, IP Mouse, Rat
HY-P80820 Phospho-GSK3 beta (Ser9) Antibody WB, IHC-F, IHC-P, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Familial Adenomatous Polyposis

Adenomatous Polyposis Coli

Fap

Familial Polyposis Coli

Familial Multiple Polyposis Syndrome

Adenomatous Polyposis Of The Colon

Familial Intestinal Polyposis

Fpc

Familial Adenomatous Polyposis Of The Colon

Familial Multiple Polyposis

Familial Polyposis Of The Colon

Hereditary Polyposis Coli

Polyposis, Adenomatous Intestinal

Adenomatous Familial Polyposis

Adenomatous Familial Polyposis Syndrome

Myh-Associated Polyposis

Colorectal Adenomatous Polyposis

Adenomatous Polyposis, Familial

Mutyh-Associate Polyposis

Myocarditis

Myocardial Inflammation

Inflammatory Cardiomyopathy

Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

Castleman Disease

Angiofollicular Ganglionic Hyperplasia

Angiofollicular Lymph Hyperplasia

Giant Lymph Node Hyperplasia

Castleman'S Disease

Angiofollicular Lymph Node Hyperplasia

Lymphoid Hamartoma

Benign Giant Lymphoma

Angiolymphoid Hyperplasia

Major Depressive Disorder

Seasonal Affective Disorder

Unipolar Depression

Depression

MDD

Depressive Disorder

Unipolar Depression, Susceptibility To

Major Depressive Disorder 1

Major Depressive Disorder, Response To Citalopram Therapy In

Major Depressive Disorder 2

Winter Depression

Single Major Depressive Episode

Sad

Clinical Depression

Major Depression

Depressive Syndrome

Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment

Seasonal Affective Disorder, Susceptibility To

Recurrent Major Depression

Affective Disorder, Seasonal

Depression In A Seasonal Pattern

Depression

Seasonal

Major Depressive Disorder With A Seasonal Pattern

Seasonal Depression

Seasonal Mood Disorder

Mental Depression

Recurrent Major Depressive Episodes

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Endometrial Cancer

Endometrial Carcinoma

Endometrial Neoplasm

Malignant Neoplasm Of Endometrium

Endometrioid Carcinoma

Endometrial Neoplasms

Carcinoma, Endometrioid

Endometrial Cancer, Familial

Endometrial Carcinoma, Somatic

Endometrial Cancer, Susceptibility To

Endometrial Ca

Malignant Endometrial Neoplasm

Neoplasm Of Endometrium

Primary Malignant Neoplasm Of Endometrium

Tumor Of Endometrium

Carcinoma Of The Endometrium

Endometrioid Carcinoma Of Female Reproductive System

ENDMC

Carcinoma Endometrioid

Endometrial Cancers

Cancer, Endometrial

Uterine Corpus Cancer

Neuroblastoma

Nb

Neuroblastoma, Susceptibility To

Neuroblastomas

Central Neuroblastoma

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Dementia

Dementias

Presenile Dementia

Alzheimer Type Dementia

Alzheimer Sclerosis

Alzheimer Disease Dementia

Alzheimer Dementia

Primary Degenerative Alzheimer Type Dementia

End Stage Alzheimer'S Dementia

Alzheimer'S Type Atypical Dementia

Alzheimer Type Presenile Dementia

Early Onset Alzheimer Dementia

Dementia In Alzheimer Disease Type 2

Dementia In Alzheimer Disease With Early Onset

Early Onset Alzheimer Type Dementia, Uncomplicated

Primary Degenerative Alzheimer Type Dementia, Early Onset

Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated

Alzheimer Disease Dementia With Early Onset

Presenile Sclerosis

Presenile Brain Sclerosis

Presenile Alzheimer Brain Sclerosis

Late Onset Alzheimer Dementia

Dementia In Alzheimer Disease Type 1

Dementia In Alzheimer Disease With Late Onset

Primary Degenerative Alzheimer Type Dementia, Late Onset

Sdat - [Senile Dementia, Alzheimer Type]

Alzheimer Disease Dementia With Late Onset

Late Onset Alzheimer Brain Sclerosis

Senile Alzheimer Brain Disease

Senile Alzheimer Brain Sclerosis

Senile Primary Degenerative Alzheimer Type Dementia

Senile Dementia Of The Alzheimer Type

Arteriosclerotic Dementia

Strategic-Infarct Dementia

Post Stroke Dementia

Vascular Cognitive Impairment

Vascular Dementia

Dementia Of The Lewy Body Type

Dementia With Lewy Bodies

Sdlt - [Senile Dementia Of The Lewy Body Type]

Senile Dementia Of The Lewy Body Type

Alcohol-Related Dementia

Alcoholic Dementia Nos

Alcohol-Induced Dementia

Alcoholic Brain Syndrome

Chronic Alcoholic Brain Syndrome

Alcohol Dementia

Late Onset Alcoholic Psychosis

Residual And Late-Onset Alcohol-Induced Psychotic Disorder

Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder

Late-Onset Psychoactive Substance-Induced Psychotic Disorder

Inhalant Dementia

Volatile Solvents Dementia

Dementia In Paralysis Agitans

Pdd - [Parkinson Disease Dementia]

Dementia Syndrome Of Parkinson Disease

Dementia In Parkinson Disease

Parkinson Related Dementia

Dementia In Huntington Chorea

Hiv - [Human Immunodeficiency Virus] Dementia

Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex

Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex

Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex

Aids Related Dementia

Dementia Due To Niacin Deficiency

Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour

Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma

Esophageal Cancer

Esophageal Carcinoma

Carcinoma Of Esophagus

Esophageal Squamous Cell Carcinoma, Somatic

Esophageal Carcinoma, Somatic

Esophagus Cancer

Gastric Cardia Adenocarcinoma

Esophageal Neoplasms

Esophageal Cancer, Somatic

Cancer Of Esophagus

Cancer Of Oesophagus

Carcinoma Of Oesophagus

Ca Lower Third Oesophagus

Ca Middle Third Oesophagus

Malignant Neoplasm Of Distal Third Of Esophagus

Malignant Neoplasm Of Lower Third Of Oesophagus

Malignant Neoplasm Of Middle Third Of Oesophagus

Malignant Neoplasm Of Proximal Third Of Esophagus

Malignant Neoplasm Of Upper Third Esophagus

Malignant Tumor Of Abdominal Esophagus

Malignant Tumor Of Distal Third Of Esophagus

Malignant Tumor Of Proximal Third Of Esophagus

Malignant Tumor Of The Middle Third Of The Esophagus

ESCR

Aerodigestive Tract Cancer

Escc

Esophageal Squamous Cell Carcinoma

Cancer, Esophageal

Malignant Neoplasm Of Esophagus

Squamous Cell Carcinoma Of Esophagus

Malignant Neoplasm Of Middle Third Of Esophagus

Severe Congenital Neutropenia

Congenital Neutropenia

Neutropenia, Severe Congenital

Congenital Agranulocytosis

Infantile Genetic Agranulocytosis

Kostmann Disease

Kostmann'S Agranulocytosis

Kostmann'S Syndrome

Severe Infantile Genetic Neutropenia

Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease

Alzheimer Disease 9

AD9

Alzheimer'S Disease 9

Alzheimer Disease 9, Susceptibility To

Alzheimer Disease 9, Late-Onset

Alzheimer'S Disease 9, Late Onset

{Alzheimer Disease 9, Susceptibility To}

Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Medulloblastoma

MDB

Cpnet

Localized Primitive Neuroectodermal Tumor

Classic Medulloblastoma

Medulloblastoma Predisposition Syndrome

Medulloblastoma, Somatic

Brain Medulloblastoma

Cns Pnet

Infratentorial Primitive Neuroectodermal Tumor

Neuroectodermal Tumors, Primitive

Medulloblastomas

Desmoplastic Medulloblastoma

Medulloblastoma, With Extensive Nodularity

Medulloblastoma Of Unspecified Site

Medullomyoblastoma Of Unspecified Site

Cervical Non-Keratinizing Squamous Cell Carcinoma
Trichothiodystrophy 7, Nonphotosensitive

TTD7

Nonphotosensitive Trichothiodystrophy 7

Trichothiodystrophy 7, Non-Photosensitive

Fallopian Tube Serous Adenocarcinoma
Diabetes Mellitus

Diabetes

Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic

Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes

Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca mulatta GSK3B VGNC VGNC:73298
Canis familiaris GSK3B VGNC VGNC:41530
Mus musculus GSK3B MGD MGI:1861437
Felis catus GSK3B VGNC VGNC:102751
Rattus norvegicus GSK3B RGD RGD:70982
Bos taurus GSK3B VGNC VGNC:106762
Others GSK3B NCBI