EIF5A2 - eukaryotic translation initiation factor 5A2 Gene

Homo sapiens

Also known as EIF-5A2; eIF5AII

Gene ID: 56648 | Gene type: protein coding

About EIF5A2

Cytogenetic location: 3q26.2 Genomic coordinates (GRCh38): 3:170,888,418-170,908,637 (from NCBI)

This gene has 5 transcripts (splice variants), 171 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 2.4), testis (RPKM 2.3) and 25 other tissues.

Summary

Predicted to enable translation elongation factor activity. Predicted to be involved in positive regulation of translational elongation. Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2022]

EIF5A2 Products(1)

mRNA	Protein	Name
NM_020390.6	NP_065123.1	eukaryotic translation initiation factor 5A-2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14622290	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF5A2 Protein Structure

eIF-5a

0
100
153 a.a.

Protein Preferred Names

Protein Names

eukaryotic translation initiation factor 5A-2

eIF-5A-2

EIF5A2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	EIF5A2	Q9GZV4	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	EIF5A2	Q9GZV4	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	EIF5A2	Q9GZV4	REL	Homo sapiens	Q04864	Validated Y2H	25416956
Intra	EIF5A2	Q9GZV4	REL	Homo sapiens	Q04864	Y2H Array	25416956
Intra	EIF5A2	Q9GZV4	CDC23	Homo sapiens	Q9UJX2	Y2H Prey Pooling	25416956
Intra	EIF5A2	Q9GZV4	SDCBP	Homo sapiens	O00560	Y2H Array	32296183
Intra	EIF5A2	Q9GZV4	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	25416956
Intra	EIF5A2	Q9GZV4	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	32296183
Intra	EIF5A2	Q9GZV4	NIF3L1	Homo sapiens	Q9GZT8	Y2H Prey Pooling	25416956
Intra	EIF5A2	Q9GZV4	DHPS	Homo sapiens	P49366	Y2H Array	32296183
Intra	EIF5A2	Q9GZV4	DHPS	Homo sapiens	P49366	Anti Tag CoIP	33961781
Intra	EIF5A2	Q9GZV4	DHPS	Homo sapiens	P49366	Y2H Prey Pooling	25416956
Intra	EIF5A2	Q9GZV4	DHPS	Homo sapiens	P49366	Validated Y2H	25416956
Intra	EIF5A2	Q9GZV4	DHPS	Homo sapiens	P49366	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EIF5A2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70910	EIF5A2 Protein, Human (His)	Q9GZV4 (M1-K153)	≥95%

Related Diseases

Diseases

Alias

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04287	EIF5A2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	EIF5A2	VGNC	VGNC:40293
Rattus norvegicus	EIF5A2	RGD	RGD:1306196
Felis catus	EIF5A2	VGNC	VGNC:61798
Bos taurus	EIF5A2	VGNC	VGNC:28419
Macaca mulatta	EIF5A2	VGNC	VGNC:72198
Mus musculus	EIF5A2	MGD	MGI:1933735
Others	EIF5A2	NCBI

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