TMPRSS4 - transmembrane serine protease 4 Gene

Homo sapiens

Also known as CAP2; CAPH2; MT-SP2; TMPRSS3

Gene ID: 56649 | Gene type: protein coding

About TMPRSS4

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:118,077,078-118,125,505 (from NCBI)

This gene has 19 transcripts (splice variants), 148 orthologues, 12 paralogues and is associated with 1 phenotype. Biased expression in colon (RPKM 31.0), urinary bladder (RPKM 28.2) and 8 other tissues.

Summary

This gene encodes a member of the serine protease family. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified as a gene overexpressed in pancreatic carcinoma. The encoded protein is membrane bound with a N-terminal anchor sequence and a glycosylated extracellular region containing the serine protease domain. The protein has been found to promote SARS-CoV-2 entry into host cells. [provided by RefSeq, Aug 2021]

TMPRSS4 Products(6)

mRNA	Protein	Name
NM_001083947.2	NP_001077416.2	transmembrane protease serine 4 isoform 3
NM_001173551.2	NP_001167022.2	transmembrane protease serine 4 isoform 4
NM_001173552.2	NP_001167023.2	transmembrane protease serine 4 isoform 5
NM_001290094.2	NP_001277023.2	transmembrane protease serine 4 isoform 6
NM_001290096.2	NP_001277025.2	transmembrane protease serine 4 isoform 7
NM_019894.4	NP_063947.2	transmembrane protease serine 4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables serine-type peptidase activity	IDA IDA: Inferred from direct assay	24434139	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within negative regulation of growth rate	IDA IDA: Inferred from direct assay	29529050	GOA
involved in positive regulation of viral entry into host cell	IDA IDA: Inferred from direct assay	32404436	GOA
involved in protein processing	IDA IDA: Inferred from direct assay	24434139	GOA
involved in proteolysis	IDA IDA: Inferred from direct assay	24434139	GOA
acts upstream of or within regulation of gene expression	IDA IDA: Inferred from direct assay	29529050	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	24434139	GOA
located in secretory granule	IDA IDA: Inferred from direct assay	29529050	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMPRSS4 Protein Structure

SRCR_2

Trypsin

0
100
200
300
400
437 a.a.

Protein Preferred Names

Protein Names

transmembrane protease serine 4

channel-activating protease 2

TMPRSS4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TMPRSS4	Q9NRS4	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	TMPRSS4	Q9NRS4	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	TMPRSS4	Q9NRS4	FNDC9	Homo sapiens	Q8TBE3	Y2H Array	32296183
Intra	TMPRSS4	Q9NRS4	FNDC9	Homo sapiens	Q8TBE3	Y2H Prey Pooling	32296183
Intra	TMPRSS4	Q9NRS4	RASGRP4	Homo sapiens	Q8TDF6-2	Y2H Array	32296183
Intra	TMPRSS4	Q9NRS4	RASGRP4	Homo sapiens	Q8TDF6-2	Y2H Prey Pooling	32296183
Intra	TMPRSS4	Q9NRS4	CLRN1	Homo sapiens	P58418	Y2H Prey Pooling	32296183
Intra	TMPRSS4	Q9NRS4	CLRN1	Homo sapiens	P58418	Y2H Array	32296183
Intra	TMPRSS4	Q9NRS4	SIGLEC12	Homo sapiens	Q96PQ1	Y2H Prey Pooling	32296183
Intra	TMPRSS4	Q9NRS4	SIGLEC12	Homo sapiens	Q96PQ1	Y2H Array	32296183
Intra	TMPRSS4	Q9NRS4	ERVFRD-1	Homo sapiens	P60508	Y2H Prey Pooling	32296183
Intra	TMPRSS4	Q9NRS4	ERVFRD-1	Homo sapiens	P60508	Y2H Array	32296183
Intra	TMPRSS4	Q9NRS4	SUSD3	Homo sapiens	Q96L08	Y2H Prey Pooling	32296183
Intra	TMPRSS4	Q9NRS4	SUSD3	Homo sapiens	Q96L08	Y2H Array	32296183
Intra	TMPRSS4	Q9NRS4	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	TMPRSS4	Q9NRS4	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	TMPRSS4	Q9NRS4	KASH5	Homo sapiens	Q8N6L0	Y2H Prey Pooling	25416956
Intra	TMPRSS4	Q9NRS4	BNIP3L	Homo sapiens	O60238	Y2H Array	32296183
Intra	TMPRSS4	Q9NRS4	BNIP3L	Homo sapiens	O60238	Y2H Prey Pooling	32296183
Intra	TMPRSS4	Q9NRS4	CSNK1D	Homo sapiens	P48730-2	Validated Y2H	32814053
Intra	TMPRSS4	Q9NRS4	CSNK1D	Homo sapiens	P48730-2	Y2H Array	32814053
Intra	TMPRSS4	Q9NRS4	CSNK1D	Homo sapiens	P48730-2	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Autosomal Recessive Cerebral Atrophy

Deafness, Autosomal Recessive 8

Neurosensory Nonsyndromic Recessive Deafness 8	DFNB8
Dfnb10	Deafness, Autosomal Recessive 10
Deafness, Childhood-Onset Neurosensory, Autosomal Recessive 8	Nsrd8
Autosomal Recessive Nonsyndromic Deafness 8	Deafness, Autosomal Recessive 8/10
Autosomal Recessive Deafness 10	Autosomal Recessive Deafness 8
Childhood-Onset Neurosensory Autosomal Recessive Deafness 8	Nrsd8
Deafness, Autosomal Recessive, 8	Childhood-Onset Neurosensory Deafness Autosomal Recessive 8
Deafness Autosomal Recessive 10	Deafness Autosomal Recessive 8/10
Deafness Neurosensory Autosomal Recessive 8	Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 8
Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 8	Deafness, Autosomal Recessive, Type 8/10

Covid-19

2019 Novel Coronavirus	2019-Ncov Infection
Covid19	Sars-Cov-2 Infection
Wuhan Coronavirus Infection	Wuhan Seafood Market Pneumonia Virus Infection

Colorectal Cancer, Hereditary Nonpolyposis, Type 8

HNPCC8	Hereditary Nonpolyposis Colorectal Cancer Type 8
Hereditary Non-Polyposis Colorectal Cancer 8	Cancer, Colorectal, Nonpolyposis, Hereditary, Type 8

Deafness, Autosomal Recessive 98

DFNB98	Autosomal Recessive Nonsyndromic Deafness 98
Autosomal Recessive Deafness 98	Deafness, Autosomal Recessive, 98
Deafness, Autosomal Recessive, Type 98

Deafness, Autosomal Recessive 4, With Enlarged Vestibular Aqueduct

Enlarged Vestibular Aqueduct	DFNB4
Neurosensory Nonsyndromic Recessive Deafness 4	Enlarged Vestibular Aqueduct Syndrome
Nsrd4	Autosomal Recessive Nonsyndromic Deafness 4
Dilated Vestibular Aqueduct	Dva
Enlarged Vestibular Aqueduct, Digenic	Autosomal Recessive Deafness 4 With Enlarged Vestibular Aqueduct
Large Vestibular Aqueduct Syndrome	Deafness, Autosomal Recessive, 4
Deafness Neurosensory Autosomal Recessive 4	Eva
Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 4	Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 4
Deafness, Autosomal Recessive, Type 4 , With Enlarged Vestibular Aqueduct

Deafness, Autosomal Recessive 39

DFNB39	Autosomal Recessive Nonsyndromic Deafness 39
Autosomal Recessive Deafness 39	Deafness, Autosomal Recessive, 39
Congenital Neurosensory Deafness Autosomal Recessive 39	Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 39
Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 39	Deafness, Autosomal Recessive, Type 39

Deafness, Autosomal Recessive 83

DFNB83	Autosomal Recessive Nonsyndromic Deafness 83
Autosomal Recessive Deafness 83

Deafness, Autosomal Recessive 77

DFNB77	Autosomal Recessive Nonsyndromic Deafness 77
Autosomal Recessive Deafness 77	Deafness, Autosomal Recessive, 77
Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 77	Deafness, Autosomal Recessive, Type 77

Petroclival Meningioma

Deafness, Autosomal Recessive 61

DFNB61	Autosomal Recessive Nonsyndromic Deafness 61
Autosomal Recessive Deafness 61	Deafness, Autosomal Recessive, 61
Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 61	Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 61
Deafness, Autosomal Recessive, Type 61

Deafness, Autosomal Recessive 42

DFNB42	Autosomal Recessive Nonsyndromic Deafness 42
Autosomal Recessive Deafness 42	Deafness, Autosomal Recessive, 42
Congenital Neurosensory Deafness Autosomal Recessive 42	Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 42
Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 42	Deafness, Autosomal Recessive, Type 42

Auditory System Disease

Ear Diseases

Ear And Mastoid Disease

Deafness, Autosomal Recessive 12

DFNB12	Deafness, Autosomal Recessive 12, Modifier Of
Autosomal Recessive Nonsyndromic Deafness 12	Autosomal Recessive Deafness 12
Deafness, Autosomal Recessive, 12	Congenital Neurosensory Deafness Autosomal Recessive 12
Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 12	Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 12
Deafness, Autosomal Recessive, Type 12

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Autosomal Recessive Nonsyndromic Deafness

Deafness, Autosomal Recessive, Nonsyndromic

Cataract 44

CTRCT44	Total Early-Onset Cataract
Cataract 44 And Hypotrichosis	Cataract And Hypotrichosis
Cataract, Type 44

Autosomal Dominant Nonsyndromic Deafness

Autosomal Dominant Deafness

Usher Syndrome Type 2

Ush2	Usher Syndrome Type Ii

Usher Syndrome

Deafness-Retinitis Pigmentosa Syndrome	Dystrophia Retinae Pigmentosa-Dysostosis Syndrome
Graefe-Usher Syndrome	Hallgren Syndrome
Usher'S Syndrome	Retinitis Pigmentosa-Deafness Syndrome
Retinitis Pigmentosa-Hearing Loss Syndrome	Ush
Usher Syndromes

Sensorineural Hearing Loss

Sensory Hearing Loss	Sensorineural Deafness
Sensorineural Hearing Loss Disorder	Hearing Loss, Sensorineural
Central Hearing Loss	High Frequency Deafness
High Frequency Hearing Loss	High-Frequency Hearing Loss
Perceptive Deafness	Perceptive Hearing Loss
Perceptive Hearing Loss Or Deafness	Hearing Loss Sensorineural
Deafness Sensorineural	Hearing Loss High-Frequency
Hearing Loss, Central	Hearing Loss, High-Frequency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14771	TMPRSS4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TMPRSS4	VGNC	VGNC:47634
Felis catus	TMPRSS4	VGNC	VGNC:66387
Bos taurus	TMPRSS4	VGNC	VGNC:36142
Macaca mulatta	TMPRSS4	VGNC	VGNC:78577
Rattus norvegicus	TMPRSS4	RGD	RGD:1305033
Mus musculus	TMPRSS4	MGD	MGI:2384877
Others	TMPRSS4	NCBI

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