NMUR2 - neuromedin U receptor 2 Gene

Homo sapiens

Also known as FM4; FM-4; TGR1; NMU2R; TGR-1; NMU-R2

Gene ID: 56923 | Gene type: protein coding

About NMUR2

Cytogenetic location: 5q33.1 Genomic coordinates (GRCh38): 5:152,391,546-152,405,279 (from NCBI)

This gene has 2 transcripts (splice variants), 131 orthologues and 15 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a protein from the G-protein coupled receptor 1 family. This protein is a receptor for neuromedin U, which is a neuropeptide that is widely distributed in the gut and central nervous system. This receptor plays an important role in the regulation of food intake and body weight. [provided by RefSeq, Jul 2008]

NMUR2 Products(1)

mRNA	Protein	Name
NM_020167.5	NP_064552.3	neuromedin-U receptor 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTP binding	IDA IDA: Inferred from direct assay	10899166	GOA
enables intracellularly calcium-gated chloride channel activity	IDA IDA: Inferred from direct assay	10899166	GOA
enables neuromedin U binding	IDA IDA: Inferred from direct assay	10894543	GOA
enables neuromedin U receptor activity	IDA IDA: Inferred from direct assay	10887190	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in arachidonate secretion	IDA IDA: Inferred from direct assay	10887190	GOA
involved in neuropeptide signaling pathway	IDA IDA: Inferred from direct assay	10894543	GOA
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	10899166	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IDA IDA: Inferred from direct assay	10899166	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NMUR2 Protein Structure

7tm_1

0
100
200
300
415 a.a.

Protein Preferred Names

Protein Names

neuromedin-U receptor 2

G-protein coupled receptor FM-4

NMUR2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NMUR2	Q9GZQ4	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Array	25416956
Intra	NMUR2	Q9GZQ4	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	25416956
Intra	NMUR2	Q9GZQ4	TRAF2	Homo sapiens	Q12933	Y2H Array	25416956
Intra	NMUR2	Q9GZQ4	TCF4	Homo sapiens	P15884	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P3030	CPN-219	Agonist	98.13%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	NMUR2	VGNC	VGNC:43867
Felis catus	NMUR2	VGNC	VGNC:63842
Bos taurus	NMUR2	VGNC	VGNC:32141
Rattus norvegicus	NMUR2	RGD	RGD:621155
Mus musculus	NMUR2	MGD	MGI:2441765
Macaca mulatta	NMUR2	VGNC	VGNC:75189

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