2. Gene
  3. PSMB6 - proteasome 20S subunit beta 6 Gene

PSMB6 - proteasome 20S subunit beta 6 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as LMPY; DELTA

Gene ID: 5694 | Gene type: protein coding

About PSMB6

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:4,796,164-4,798,495 (from NCBI)

This gene has 5 transcripts (splice variants), 212 orthologues and 18 paralogues. Ubiquitous expression in placenta (RPKM 53.0), heart (RPKM 51.7) and 25 other tissues.

Summary

The Proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave Peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the Proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the Proteasome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

PSMB6 Products(2)

mRNA Protein Name
NM_001270481.2 NP_001257410.1 proteasome subunit beta type-6 isoform 2
NM_002798.3 NP_002789.1 proteasome subunit beta type-6 isoform 1
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
14733938 GOA
Cellular Component GO Annotation Evidence Reference Source
is active in cytoplasm IDA
IDA: Inferred from direct assay
34711951 GOA
is active in nucleus IDA
IDA: Inferred from direct assay
34711951 GOA
part of proteasome complex IDA
IDA: Inferred from direct assay
17323924 GOA
part of proteasome core complex IDA
IDA: Inferred from direct assay
34711951 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSMB6 Protein Structure

Proteasome

Proteasome: Proteasome subunit (31 - 212)

  • 0
  • 100
  • 200
  • 239 a.a.
Protein Preferred Names Protein Names

proteasome subunit beta type-6

PSY large multifunctional protease Y

PSMB6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PSMB6 P28072 NDOR1 Homo sapiens Q9UHB4
Validated Y2H
32296183
Intra
PSMB6 P28072 HTT Homo sapiens P42858
Y2H Pooling
32814053
Intra
PSMB6 P28072 HTT Homo sapiens P42858
Validated Y2H
32814053
Intra
PSMB6 P28072 HTT Homo sapiens P42858
Y2H Array
32814053
Intra
PSMB6 P28072 POMP Homo sapiens Q9Y244
Anti Tag CoIP
35271311
Intra
PSMB6 P28072 POMP Homo sapiens Q9Y244
Y2H
14733938
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11306 PSMB6 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PSMB6 VGNC VGNC:99326
Rattus norvegicus PSMB6 RGD RGD:61881
Bos taurus PSMB6 VGNC VGNC:33450
Canis familiaris PSMB6 VGNC VGNC:45098
Mus musculus PSMB6 MGD MGI:104880
Macaca mulatta PSMB6 VGNC VGNC:104644
Others PSMB6 NCBI