PSMB6 - proteasome 20S subunit beta 6 Gene

Homo sapiens

Also known as LMPY; DELTA

Gene ID: 5694 | Gene type: protein coding

About PSMB6

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:4,796,164-4,798,495 (from NCBI)

This gene has 5 transcripts (splice variants), 212 orthologues and 18 paralogues. Ubiquitous expression in placenta (RPKM 53.0), heart (RPKM 51.7) and 25 other tissues.

Summary

The Proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave Peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the Proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the Proteasome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

PSMB6 Products(2)

mRNA	Protein	Name
NM_001270481.2	NP_001257410.1	proteasome subunit beta type-6 isoform 2
NM_002798.3	NP_002789.1	proteasome subunit beta type-6 isoform 1

PSMB6 Protein Structure

Proteasome

0
100
200
239 a.a.

Protein Preferred Names

Protein Names

proteasome subunit beta type-6

PSY large multifunctional protease Y

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11306	PSMB6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PSMB6	VGNC	VGNC:99326
Rattus norvegicus	PSMB6	RGD	RGD:61881
Bos taurus	PSMB6	VGNC	VGNC:33450
Canis familiaris	PSMB6	VGNC	VGNC:45098
Mus musculus	PSMB6	MGD	MGI:104880
Macaca mulatta	PSMB6	VGNC	VGNC:104644
Others	PSMB6	NCBI

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