2. Gene
  3. OTUD7B - OTU deubiquitinase 7B Gene

OTUD7B - OTU deubiquitinase 7B Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ZA20D1; CEZANNE

Gene ID: 56957 | Gene type: protein coding

About OTUD7B

Cytogenetic location: 1q21.2 Genomic coordinates (GRCh38): 1:149,937,812-150,067,653 (from NCBI)

This gene has 3 transcripts (splice variants), 202 orthologues and 2 paralogues. Ubiquitous expression in fat (RPKM 4.7), testis (RPKM 4.3) and 25 other tissues.

Summary

Enables Lys48-specific Deubiquitinase activity and thiol-dependent Deubiquitinase. Involved in several processes, including negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of macromolecule metabolic process; and protein deubiquitination. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

OTUD7B Products(1)

mRNA Protein Name
NM_020205.4 NP_064590.2 OTU domain-containing protein 7B

OTUD7B Protein Structure

UBA_4

UBA_4: UBA-like domain (9 - 41)

OTU

OTU: OTU-like cysteine protease (189 - 359)

  • 0
  • 200
  • 400
  • 600
  • 843 a.a.
Protein Preferred Names Protein Names

OTU domain-containing protein 7B

OTU domain containing 7B

Related Diseases

Diseases Alias
Salivary Gland Adenoid Cystic Carcinoma

Cylindroma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09877 OTUD7B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus OTUD7B MGD MGI:2654703
Macaca mulatta OTUD7B VGNC VGNC:75634
Felis catus OTUD7B VGNC VGNC:64003
Rattus norvegicus OTUD7B RGD RGD:1308111
Bos taurus OTUD7B VGNC VGNC:32500
Canis familiaris OTUD7B VGNC VGNC:44191
Others OTUD7B NCBI