OTUD7B - OTU deubiquitinase 7B Gene

Homo sapiens

Also known as ZA20D1; CEZANNE

Gene ID: 56957 | Gene type: protein coding

About OTUD7B

Cytogenetic location: 1q21.2 Genomic coordinates (GRCh38): 1:149,937,812-150,067,653 (from NCBI)

This gene has 3 transcripts (splice variants), 202 orthologues and 2 paralogues. Ubiquitous expression in fat (RPKM 4.7), testis (RPKM 4.3) and 25 other tissues.

Summary

Enables Lys48-specific Deubiquitinase activity and thiol-dependent Deubiquitinase. Involved in several processes, including negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of macromolecule metabolic process; and protein deubiquitination. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

OTUD7B Products(1)

mRNA	Protein	Name
NM_020205.4	NP_064590.2	OTU domain-containing protein 7B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables K48-linked deubiquitinase activity	IDA IDA: Inferred from direct assay	21097510	GOA
enables cysteine-type deubiquitinase activity	IDA IDA: Inferred from direct assay	23827681	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11463333	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	11463333	GOA
acts upstream of negative regulation of interleukin-8 production	IDA IDA: Inferred from direct assay	21097510	GOA
involved in negative regulation of protein localization to nucleus	IDA IDA: Inferred from direct assay	21097510	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21097510	GOA
involved in protein K11-linked deubiquitination	IDA IDA: Inferred from direct assay	20622874	GOA
involved in protein K48-linked deubiquitination	IDA IDA: Inferred from direct assay	21097510	GOA
involved in protein K63-linked deubiquitination	IDA IDA: Inferred from direct assay	20622874	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11463333	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11463333	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OTUD7B Protein Structure

UBA_4

OTU

0
200
400
600
843 a.a.

Protein Preferred Names

Protein Names

OTU domain-containing protein 7B

OTU domain containing 7B

OTUD7B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	OTUD7B	Q6GQQ9	SAXO4	Homo sapiens	Q7Z5V6-2	Validated Y2H	32296183
Intra	OTUD7B	Q6GQQ9	SPART	Homo sapiens	Q8N0X7	Validated Y2H	32296183
Intra	OTUD7B	Q6GQQ9	CDIP1	Homo sapiens	Q9H305	Validated Y2H	32296183
Intra	OTUD7B	Q6GQQ9	HSFY1	Homo sapiens	Q96LI6	Validated Y2H	32296183
Intra	OTUD7B	Q6GQQ9	EPM2AIP1	Homo sapiens	Q7L775	Validated Y2H	32296183
Intra	OTUD7B	Q6GQQ9	CCDC50	Homo sapiens	Q8IVM0	Anti Tag CoIP	18029035
Intra	OTUD7B	Q6GQQ9	CCDC50	Homo sapiens	Q8IVM0	Y2H	18029035
Intra	OTUD7B	Q6GQQ9	CCDC50	Homo sapiens	Q8IVM0	IF	18029035
Intra	OTUD7B	Q6GQQ9	CCDC50	Homo sapiens	Q8IVM0	Pull Down	18029035
Intra	OTUD7B	Q6GQQ9	CCDC50	Homo sapiens	Q8IVM0	Anti Bait CoIP	18029035
Intra	OTUD7B	Q6GQQ9	OTULIN	Homo sapiens	Q96BN8	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Salivary Gland Adenoid Cystic Carcinoma

Cylindroma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09877	OTUD7B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	OTUD7B	MGD	MGI:2654703
Macaca mulatta	OTUD7B	VGNC	VGNC:75634
Felis catus	OTUD7B	VGNC	VGNC:64003
Rattus norvegicus	OTUD7B	RGD	RGD:1308111
Bos taurus	OTUD7B	VGNC	VGNC:32500
Canis familiaris	OTUD7B	VGNC	VGNC:44191
Others	OTUD7B	NCBI

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