PYY - peptide YY Gene

Homo sapiens

Also known as PYY1; PYY-I

Gene ID: 5697 | Gene type: protein coding

About PYY

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:43,952,733-44,004,445 (from NCBI)

This gene has 3 transcripts (splice variants), 250 orthologues and 2 paralogues. Biased expression in colon (RPKM 24.9) and small intestine (RPKM 4.4).

Summary

This gene encodes a member of the neuropeptide Y (NPY) family of Peptides. The encoded preproprotein is proteolytically processed to generate two alternative peptide products that differ in length by three Amino acids. These Peptides, secreted by endocrine cells in the gut, exhibit different binding affinities for each of the neuropeptide Y receptors. Binding of the encoded Peptides to these receptors mediates regulation of pancreatic secretion, gut mobility and energy homeostasis. Rare variations in this gene could increase susceptibility to obesity and elevated serum levels of the encoded Peptides may be associated with anorexia nervosa. [provided by RefSeq, Feb 2016]

PYY Products(3)

mRNA	Protein	Name
NM_001394028.1	NP_001380957.1	peptide YY isoform 1 preproprotein
NM_001394029.1	NP_001380958.1	peptide YY isoform 2 precursor
NM_004160.6	NP_004151.4	peptide YY isoform 1 preproprotein

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled receptor binding	IPI IPI: Inferred from physical interaction	7493937	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23597562	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PYY Protein Structure

Hormone_3

0
97 a.a.

Protein Preferred Names

Protein Names

peptide YY

peptide tyrosine tyrosine

Related Diseases

Diseases

Alias

Anorexia Nervosa

Anorexia Nervosa, Susceptibility To	ANON
Anorexia Nervosa, Susceptibility To, 1	An
Anorexia Nervosa 1	An - [Anorexia Nervosa]

N-Acetylglutamate Synthase Deficiency

Nags Deficiency	N-Acetylglutamate Synthetase Deficiency
Hyperammonemia, Type Iii	Hyperammonemia Due To N-Acetylglutamate Synthetase Deficiency
NAGSD	Hyperammonemia Due To N-Acetylglutamate Synthase Deficiency
N-Acetyl Glutamate Synthetase Deficiency	Nag Synthetase Deficiency
Deficiency, N-Acetylglutamate Synthase

Bulimia Nervosa

Bulimia	Bulimia Nervosa, Susceptibility To
Binge Eating Disorder	BULN
Bn	Hyperorexia Nervosa
Bulimia Nervosa 2	BULN2
Susceptibility To Bulimia Nervosa	Bulimia Nervosa, Susceptibility To, Type 2
Bn - [Bulimia Nervosa]	Bulimia Nos
Bulimic	Bingeing
Binge Overeating	Bouts Of Overeating
Episodes Of Overeating

Eating Disorder

Eating Disorders

Feeding And Eating Disorders

Short Bowel Syndrome

Short Gut Syndrome	Acquired Short Bowel Syndrome
Secondary Short Bowel Syndrome	Short Bowel Nos

Dumping Syndrome

Jejunal Syndrome	Dumping
Dumping Syndrome	Postgastrectomy Syndromes
Postgastric Surgery Syndrome	Postgastrectomy Syndrome
Post Cibal Syndrome	Postgastrectomy Dumping Syndrome

Leptin Deficiency Or Dysfunction

Morbid Obesity	Obesity Due To Congenital Leptin Deficiency
LEPD	Congenital Leptin Deficiency
Obesity, Morbid	Obesity, Morbid, Due To Leptin Deficiency
Severe Obesity	Obesity, Morbid, Nonsyndromic 1
Leptin Deficiency	Obesity, Severe, Due To Leptin Deficiency
Leptin	Morbid Obesity Due To Leptin Deficiency
Obesity Morbid	Leptin Dysfunction

Postgastrectomy Syndrome

Postgastrectomy Syndromes

Postgastric Surgery Syndrome

Duodenogastric Reflux

Prader-Willi Syndrome

Prader-Labhart-Willi Syndrome	PWS
Willi-Prader Syndrome	Prader-Willi Syndrome Due To Translocation
Prader-Willi Syndrome Due To Imprinting Mutation	Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15
Prader Willi Syndrome	Upd(15)Mat

Gastroesophageal Reflux

Gastroesophageal Reflux Disease	Gerd
GER	Gastroesophageal Reflux, Pediatric
Acid Reflux	Gastresophageal Reflux
Gastro-Esophageal Reflux	Gerd - Gastro-Esophageal Reflux Disease

Constipation

Irritable Bowel Syndrome

Irritable Colon	Psychogenic Ibs
Ibs - [Irritable Bowel Syndrome]	Spastic Bowel Syndrome

Hyperglycemia

Amenorrhea

Absence Of Menstruation

Amenia

Gastroenteritis

Cholera Morbus	Infectious Colitis, Enteritis And Gastroenteritis
Enteritis Due To Astrovirus	Rotaviral Gastroenteritis
Viral Gastroenteritis Due To Rotavirus

Carcinoid Syndrome

Carcinoid Tumor	Malignant Carcinoid Syndrome
Carcinoid Tumor Syndrome	Carcinoid Tumors
Carcinoid Tumor No Icd-O Subtype	Argentaffinoma Syndrome

Diversion Colitis

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Functional Gastric Disease

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Diarrhea

Diarrhoea

Diarrhea Of Presumed Infectious Origin

Tropical Sprue

Tropical Steatorrhea	Tropical Enteropathy
Sprue, Tropical	Sprue - Tropical
Idiopathic Tropical Malabsorption Syndrome	Tropical Steatorrhoea
Tropical Diarrhoea	Ts - [Tropical Sprue]
Psilosis	Sprue Nos

Chylomicron Retention Disease

CMRD	Anderson Disease
Lipid Transport Defect Of Intestine	Hypobetalipoproteinemia With Accumulation Of Apolipoprotein B-Like Protein In Intestinal Cells
Andd	Anderson Syndrome
Crd	Andersons Disease
Malabsorption Syndrome

Ovary Leiomyosarcoma

Leiomyosarcoma Of Ovary

Lymphocytic Colitis

Colitis, Lymphocytic

Blind Loop Syndrome

Bacterial Overgrowth Syndrome

Nutritional Deficiency Disease

Malnutrition	Nutritional Disorder
Nutritional Deficiency	Nutrition
Deficiency Diseases	Carbamoyl-Phosphate Synthase I Deficiency Disease
Nutrition Disorders

Celiac Disease 1

Celiac Disease	Coeliac Disease
Celiac Sprue	Celiac Disease, Susceptibility To
Gluten-Sensitive Enteropathy	Nontropical Sprue
Sprue	CELIAC1
Celiac Disease, Susceptibility To, 1	Celiac Sprue 1
Celiac Sprue, Susceptibility To, 1	Gluten-Sensitive Enteropathy 1
Gluten-Sensitive Enteropathy, Susceptibility To, 1	Idiopathic Steatorrhea
Cœliac Disease	Gluten Intolerance
Gluten-Induced Enteropathy	Gluten Enteropathy
Celiac Disease, Susceptibility To, Type 1	Childhood Celiac Disease
Coeliac Rickets	Gee Disease
Gee-Herter Disease	Heubner-Herter Disease
Idiopathic Steatorrhoea	Thaysen'S Disease
Herter Gee Syndrome

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Serotonin Syndrome

Serotonergic Syndrome	Serotonin Storm
Serotonin Toxicity	Serotonin Toxidrome
Malignant Carcinoid Syndrome

Microscopic Colitis

Colitis, Microscopic

Volvulus Of Midgut

Volvulus	Intestinal Volvulus
Intestinal Malrotation, Familial	Familial Intestinal Malrotation
Twist Of Intestine, Bowel, Or Colon

Overnutrition

Apnea, Obstructive Sleep

Obstructive Sleep Apnea Syndrome	Obstructive Sleep Apnea
Sleep Apnea, Obstructive	Osa
Osas	Sleep Apnea/Hypopnea Syndrome
Sahs	Upper Airway Resistance Sleep Apnea Syndrome
Apnea, Obstructive	Obstructive Apnea
Osahs	Sleep Apnea Hypopnea Syndrome
Sleep Apnea Syndrome, Obstructive	Sleep Apnea Obstructive
Sleep Apnea Syndromes	Obstructive Sleep Apnoea Syndrome
Obstructive Sleep Apnoea, Adult	Osa - [Obstructive Sleep Apnoea]
Obstructive Sleep Apnoea, Paediatric	Obstructive Sleep Apnoea Hypopnoea Syndrome
Osa Syndrome	Sleep Apnoea Nos
[Sas] - Sleep Apnoea Syndrome	Sleep Apnoea Syndrome
[Osahs] - Obstructive Sleep Apnoea-Hypopnea Syndrome	[Sahs] - Sleep Apnoea-Hypopnea Syndrome

Acquired Metabolic Disease

Arthrogryposis, Distal, Type 1c

DA1C	Distal Arthrogryposis Type 1c
Arthrogryposis, Distal, 1c

Diabetes Mellitus

Diabetes

Endometrial Small Cell Carcinoma

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Gallbladder Disease

Gallbladder Diseases	Gall Bladder
Gall Bladder Diseases	Abnormal Gallbladder Function

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101986	BIIE-0246	Antagonist	99.10%	Unkown
HY-P1514	Peptide YY (PYY), human		99.77%	Unkown
HY-P10000	Peptide YY (PYY) (3-36), Human	Agonist	98.57%	Unkown
HY-101986A	BIIE-0246 hydrochloride	Antagonist	≥99.0%	Unkown
HY-P1021A	Peptide YY (PYY) (3-36), porcine TFA	Agonist	98.17%	Unkown
HY-107732	JNJ-5207787	Antagonist	≥98.0%	Unkown
HY-P1021	Peptide YY (PYY) (3-36), porcine	Antagonist	/	Unkown
HY-P3877A	(Leu31,Pro34)-Peptide YY (human) (TFA)	Agonist	99.96%	Unkown
HY-P3877	(Leu31,Pro34)-Peptide YY (human)	Agonist	/	Unkown
HY-RS11497	PYY Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PYY	MGD	MGI:99924
Rattus norvegicus	PYY	RGD	RGD:1593289
Macaca mulatta	PYY	VGNC	VGNC:99215
Others	PYY	NCBI