AKR1B10 - aldo-keto reductase family 1 member B10 Gene

Homo sapiens

Also known as HIS; HSI; ARL1; ARL-1; ALDRLn; AKR1B11; AKR1B12

Gene ID: 57016 | Gene type: protein coding

About AKR1B10

Cytogenetic location: 7q33 Genomic coordinates (GRCh38): 7:134,527,567-134,541,412 (from NCBI)

This gene has 4 transcripts (splice variants), 563 orthologues and 16 paralogues. Biased expression in duodenum (RPKM 190.1), stomach (RPKM 138.2) and 4 other tissues.

Summary

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known Enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis. [provided by RefSeq, Jul 2008]

AKR1B10 Products(1)

mRNA	Protein	Name
NM_020299.5	NP_064695.3	aldo-keto reductase family 1 member B10

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables alcohol dehydrogenase (NADP+) activity	IDA IDA: Inferred from direct assay	19013440	GOA
enables all-trans-retinol dehydrogenase (NADP+) activity	IDA IDA: Inferred from direct assay	12732097	GOA
enables geranylgeranyl reductase activity	IDA IDA: Inferred from direct assay	21187079	GOA
enables indanol dehydrogenase activity	IDA IDA: Inferred from direct assay	20837989	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18056116	GOA
enables retinal dehydrogenase activity	IDA IDA: Inferred from direct assay	21851338	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular detoxification of aldehyde	IDA IDA: Inferred from direct assay	19013440	GOA
involved in daunorubicin metabolic process	IMP IMP: Inferred from mutant phenotype	20837989	GOA
involved in doxorubicin metabolic process	IMP IMP: Inferred from mutant phenotype	20837989	GOA
involved in farnesol catabolic process	IDA IDA: Inferred from direct assay	21187079	GOA
involved in retinoid metabolic process	IDA IDA: Inferred from direct assay	12732097	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular region	IDA IDA: Inferred from direct assay	21585341	GOA
located in lysosome	IDA IDA: Inferred from direct assay	21585341	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AKR1B10 Protein Structure

Aldo_ket_red

0
100
200
316 a.a.

Protein Preferred Names

Protein Names

aldo-keto reductase family 1 member B10

ARP

AKR1B10 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	AKR1B10	O60218	AKR1B15	Homo sapiens	C9JRZ8	Anti Tag CoIP	33961781
Intra	AKR1B10	O60218	ACACA	Homo sapiens	Q13085	Anti Bait CoIP	18056116
Intra	AKR1B10	O60218	ACACA	Homo sapiens	Q13085	Confocal	18056116
Intra	AKR1B10	O60218	TERF2IP	Homo sapiens	Q9NYB0	BiFC	21044950
Intra	AKR1B10	O60218	TERF2IP	Homo sapiens	Q9NYB0	Pull Down	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

AKR1B10 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81368	AKR1B10 Antibody (YA1113)	IHC-P	Human

Related Diseases

Diseases

Alias

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Diabetic Cataract

Cataract - Diabetic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-105185	Fidarestat	Inhibitor	99.63%	Unkown

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-139696	AKR1B10-IN-1	Inhibitor	≥95.0%	Unkown
HY-W040265	Fenamic acid	Inhibitor	98.19%	Unkown
HY-RS00533	AKR1B10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-168526	Keap1-Nrf2-IN-24	Inhibitor	/	Unkown
HY-122177	MK181	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	AKR1B10	RGD	RGD:1308277
Others	AKR1B10	NCBI

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