PDXP - pyridoxal phosphatase Gene

Homo sapiens

Also known as CIN; PLP; dJ37E16.5

Gene ID: 57026 | Gene type: protein coding

About PDXP

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:37,658,723-37,666,932 (from NCBI)

This gene has 2 transcripts (splice variants), 194 orthologues and 3 paralogues. Broad expression in brain (RPKM 43.8), small intestine (RPKM 14.2) and 21 other tissues.

Summary

Pyridoxal 5-prime-phosphate (PLP) is the active form of vitamin B6 that acts as a coenzyme in maintaining biochemical homeostasis. The preferred degradation route from PLP to 4-pyridoxic acid involves the dephosphorylation of PLP by PDXP (Jang et al., 2003 [PubMed 14522954]).[supplied by OMIM, Mar 2008]

PDXP Products(1)

mRNA	Protein	Name
NM_020315.5	NP_064711.1	chronophin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables heat shock protein binding	IDA IDA: Inferred from direct assay	19000834	GOA
enables phosphoprotein phosphatase activity	IDA IDA: Inferred from direct assay	15580268	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17500066	GOA
enables pyridoxal phosphatase activity	IDA IDA: Inferred from direct assay	8132548	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within actin rod assembly	IDA IDA: Inferred from direct assay	19000834	GOA
acts upstream of or within actin rod assembly	IMP IMP: Inferred from mutant phenotype	19000834	GOA
acts upstream of or within cellular response to ATP	IDA IDA: Inferred from direct assay	19000834	GOA
involved in dephosphorylation	IDA IDA: Inferred from direct assay	8132548	GOA
involved in positive regulation of actin filament depolymerization	IMP IMP: Inferred from mutant phenotype	15580268	GOA
involved in protein dephosphorylation	IDA IDA: Inferred from direct assay	15580268	GOA
involved in pyridoxal phosphate catabolic process	IDA IDA: Inferred from direct assay	8132548	GOA
involved in regulation of cytokinesis	IMP IMP: Inferred from mutant phenotype	15580268	GOA
involved in regulation of mitotic nuclear division	IMP IMP: Inferred from mutant phenotype	15580268	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
colocalizes with actin cytoskeleton	IDA IDA: Inferred from direct assay	15580268	GOA
colocalizes with cleavage furrow	IDA IDA: Inferred from direct assay	15580268	GOA
colocalizes with contractile ring	IDA IDA: Inferred from direct assay	15580268	GOA
located in cytosol	IDA IDA: Inferred from direct assay	15580268	GOA
colocalizes with lamellipodium	IDA IDA: Inferred from direct assay	15580268	GOA
colocalizes with midbody	IDA IDA: Inferred from direct assay	15580268	GOA
colocalizes with plasma membrane	IDA IDA: Inferred from direct assay	15580268	GOA
colocalizes with ruffle membrane	IDA IDA: Inferred from direct assay	15580268	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDXP Protein Structure

Hydrolase_6

Hydrolase_like

0
100
200
296 a.a.

Protein Preferred Names

Protein Names

chronophin

PLP phosphatase

PDXP Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	PDXP	Q96GD0	Arrb1	Rattus norvegicus	P29066	Anti Tag CoIP	17500066

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Contractural Arachnodactyly, Congenital

Congenital Contractural Arachnodactyly	Beals Syndrome
CCA	Beals-Hecht Syndrome
Distal Arthrogryposis Type 9	Arthrogryposis, Distal, Type 9
Da9	Arachnodactyly, Contractural Beals Type
Contractures, Multiple With Arachnodactyly	Ear Anomalies-Contractures-Dysplasia Of Bone With Kyphoscoliosis
Arthrogyroposis, Distal, Type 9	Distal Arthrogyropsis Type 9
Cca Syndrome	Arachnodactyly

Laurence-Moon Syndrome

LNMS	Laurence-Moon-Biedl Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10298	PDXP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PDXP	MGD	MGI:1919282
Rattus norvegicus	PDXP	RGD	RGD:1586212
Bos taurus	PDXP	VGNC	VGNC:32722
Canis familiaris	PDXP	VGNC	VGNC:44397
Others	PDXP	NCBI

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