1. Gene
  2. Arrb1 - arrestin, beta 1 Gene

Arrb1 - arrestin, beta 1 Gene

Rattus norvegicus

Also known as BARRES

Gene ID: 25387 | Gene type: protein coding

About Arrb1

Summary

Enables several functions, including AP-2 adaptor complex binding activity; G protein-coupled receptor binding activity; and Arrestin family protein binding activity. Involved in several processes, including regulation of ERK1 and ERK2 cascade; regulation of apoptotic process; and regulation of cellular protein metabolic process. Located in several cellular components, including basolateral plasma membrane; dendritic spine; and postsynaptic density. Used to study congestive heart failure. Biomarker of colitis. Orthologous to human ARRB1 (Arrestin beta 1). [provided by Alliance of Genome Resources, Apr 2022]

Arrb1 Products(1)

mRNA Protein Name
NM_012910.2 NP_037042.1 beta-arrestin-1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables AP-2 adaptor complex binding IDA
IDA: Inferred from direct assay
15728179 RGD
enables V2 vasopressin receptor binding IDA
IDA: Inferred from direct assay
17513300 RGD
enables alpha-1A adrenergic receptor binding IPI
IPI: Inferred from physical interaction
18523139 RGD
enables alpha-1B adrenergic receptor binding IDA
IDA: Inferred from direct assay
18523139 RGD
enables arrestin family protein binding IPI
IPI: Inferred from physical interaction
23886940 RGD
enables clathrin adaptor activity IDA
IDA: Inferred from direct assay
15728179 RGD
enables clathrin binding IDA
IDA: Inferred from direct assay
17513300 RGD
enables enzyme binding IPI
IPI: Inferred from physical interaction
12399592 RGD
enables follicle-stimulating hormone receptor binding IPI
IPI: Inferred from physical interaction
16899567 RGD
enables nuclear estrogen receptor binding IPI
IPI: Inferred from physical interaction
19339617 RGD
enables phosphoprotein binding IPI
IPI: Inferred from physical interaction
11742073 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
10725339 RGD
enables protein phosphorylated amino acid binding IDA
IDA: Inferred from direct assay
17513300 RGD
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
23604254 RGD
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
20650893 RGD
Biological Process GO Annotation Evidence Reference Source
involved in G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
1517224 RGD
involved in endocytosis IDA
IDA: Inferred from direct assay
12519791 RGD
involved in follicle-stimulating hormone signaling pathway IDA
IDA: Inferred from direct assay
16899567 RGD
involved in negative regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
19254952 RGD
involved in negative regulation of GTPase activity IDA
IDA: Inferred from direct assay
1517224 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
24378649 RGD
involved in negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
26621121 RGD
involved in negative regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
19254952 RGD
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
19289825 RGD
involved in positive regulation of MAPK cascade IDA
IDA: Inferred from direct assay
12167719 RGD
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
25486571 RGD
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
19171933 RGD
involved in positive regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
24378649 RGD
involved in positive regulation of protein ubiquitination IMP
IMP: Inferred from mutant phenotype
20650893 RGD
involved in positive regulation of smooth muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
19171933 RGD
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16325578 RGD
involved in regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11742073 RGD
involved in regulation of G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
1517224 RGD
involved in regulation of inositol trisphosphate biosynthetic process IMP
IMP: Inferred from mutant phenotype
20705669 RGD
involved in response to morphine IEP
IEP: Inferred from expression pattern
12614678 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
21223624 RGD
Cellular Component GO Annotation Evidence Reference Source
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
16899567 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
1517224 RGD
located in endosome IDA
IDA: Inferred from direct assay
25016018 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
1517224 RGD
is active in postsynaptic density IDA
IDA: Inferred from direct assay
1517224 RGD
located in postsynaptic membrane IDA
IDA: Inferred from direct assay
1517224 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

beta-arrestin-1

Arrb1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Cross
Arrb1 P29066 TP53 Homo sapiens P04637
Pull Down
21857681
Cross
Arrb1 P29066 TP53 Homo sapiens P04637
Anti Tag CoIP
21857681
Cross
Arrb1 P29066 PDXP Homo sapiens Q96GD0
Anti Tag CoIP
17500066
Cross
Arrb1 P29066 F2RL1 Homo sapiens P55085
GMS
10725339
Cross
Arrb1 P29066 F2RL1 Homo sapiens P55085
Confocal
10725339
Cross
Arrb1 P29066 F2RL1 Homo sapiens P55085
Anti Tag CoIP
10725339
Cross
Arrb1 P29066 LIMK1 Homo sapiens P53667
Pull Down
17500066
Intra
Arrb1 P29066 Raf1 Rattus norvegicus P11345
GMS
10725339
Intra
Arrb1 P29066 Raf1 Rattus norvegicus P11345
Anti Tag CoIP
10725339
Intra
Arrb1 P29066 Raf1 Rattus norvegicus P11345
Confocal
10725339
Cross: Cross-species interaction Intra: Intraspecies interaction

Orthologs Information

Species Symbol Source ID
Homo sapiens Arrb1 NCBI NCBI:408