UTP3 - UTP3 small subunit processome component Gene

Homo sapiens

Also known as CRL1; CRLZ1; SAS10

Gene ID: 57050 | Gene type: protein coding

About UTP3

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:70,688,532-70,690,551 (from NCBI)

This gene has 1 transcript (splice variant), 174 orthologues and 1 paralogue.

Summary

Enables RNA binding activity. Predicted to be involved in brain development and maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]

UTP3 Products(1)

mRNA	Protein	Name
NM_020368.3	NP_065101.1	something about silencing protein 10

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ribosomal small subunit biogenesis	IDA IDA: Inferred from direct assay	34516797	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of small-subunit processome	IDA IDA: Inferred from direct assay	34516797	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UTP3 Protein Structure

Sas10_Utp3

Sas10

0
100
200
300
400
479 a.a.

Protein Preferred Names

Protein Names

something about silencing protein 10

UTP3 homolog

UTP3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	UTP3	Q9NQZ2	C1orf131	Homo sapiens	Q8NDD1-6	Y2H Array	32296183
Intra	UTP3	Q9NQZ2	C1orf131	Homo sapiens	Q8NDD1-6	Y2H Prey Pooling	32296183
Intra	UTP3	Q9NQZ2	H1-4	Homo sapiens	P10412	Crosslink	30021884
Intra	UTP3	Q9NQZ2	CDCA7L	Homo sapiens	Q96GN5	Validated Y2H	25416956
Intra	UTP3	Q9NQZ2	CDCA7L	Homo sapiens	Q96GN5	Y2H Prey Pooling	25416956
Intra	UTP3	Q9NQZ2	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	32296183
Intra	UTP3	Q9NQZ2	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	32296183
Intra	UTP3	Q9NQZ2	DVL3	Homo sapiens	Q92997	Validated Y2H	25416956
Intra	UTP3	Q9NQZ2	DVL3	Homo sapiens	Q92997	Y2H Array	25416956
Intra	UTP3	Q9NQZ2	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	UTP3	Q9NQZ2	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	UTP3	Q9NQZ2	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	UTP3	Q9NQZ2	H1-1	Homo sapiens	Q02539	Crosslink	30021884

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Palmoplantar Keratoderma, Bothnian Type

PPKB	Diffuse Palmoplantar Keratoderma, Bothnian Type
Bothnian Type Palmoplantar Keratoderma	Keratoderma, Palmoplantar, Bothnian Type
Palmoplantar Keratoderma, Nonepidermolytic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15579	UTP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	UTP3	VGNC	VGNC:36746
Felis catus	UTP3	VGNC	VGNC:66906
Canis familiaris	UTP3	VGNC	VGNC:48213
Macaca mulatta	UTP3	VGNC	VGNC:79434
Mus musculus	UTP3	MGD	MGI:1919230
Rattus norvegicus	UTP3	RGD	RGD:1308540

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