H1-4 - H1.4 linker histone, cluster member Gene

Homo sapiens

Also known as H1E; H1.4; H1F4; RMNS; H1s-4; HIST1H1E; dJ221C16.5

Gene ID: 3008 | Gene type: protein coding

About H1-4

Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:26,156,329-26,157,115 (from NCBI)

This gene has 1 transcript (splice variant), 128 orthologues, 9 paralogues and is associated with 2 phenotypes.

Summary

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

H1-4 Products(1)

mRNA	Protein	Name
NM_005321.3	NP_005312.1	histone H1.4

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chromatin DNA binding	IMP IMP: Inferred from mutant phenotype	15911621	GOA
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	15469825	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17474147	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in heterochromatin	IDA IDA: Inferred from direct assay	15911621	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17540172	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

H1-4 Protein Structure

Linker_histone

0
100
200
219 a.a.

Protein Preferred Names

Protein Names

histone H1.4

H1 histone family, member 4

H1-4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	H1-4	P10412	H2BC21	Homo sapiens	Q16778	Crosslink	30021884
Intra	H1-4	P10412	L3MBTL1	Homo sapiens	Q9Y468	Pull Down	17540172
Cross	H1-4	P10412	N	SARS-CoV-2	P0DTC9	Anti Tag CoIP	36217030
Intra	H1-4	P10412	UTP3	Homo sapiens	Q9NQZ2	Anti Tag CoIP	33961781
Intra	H1-4	P10412	FTSJ3	Homo sapiens	Q8IY81	Anti Tag CoIP	33961781
Intra	H1-4	P10412	FTSJ3	Homo sapiens	Q8IY81	Anti Tag CoIP	28514442
Intra	H1-4	P10412	BAZ1B	Homo sapiens	Q9UIG0	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

H1-4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83304	Phospho-Histone H1.4 (Thr17) Antibody (YA3049)	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Rahman Syndrome

RMNS

Hist1h1e Syndrome

Rahman Syndrome

Plasma Cell Neoplasm

Plasma Cell Dyscrasia	Paraproteinemias
Plasma Cell Tumour	Plasmacytic Tumor
Multiple Myeloma	Plasmacytoma
Plasma Cell Tumours	Plasma Cells Dyscrasia

Myeloma, Multiple

Multiple Myeloma	Plasma Cell Myeloma
Kahler Disease	Myelomatosis
Medullary Plasmacytoma	Multiple Myeloma, Resistance To
Myeloma	Plasma Cell Dyscrasia
Kahler'S Disease	Multiple Myeloma, Susceptibility To
Myeloma - Multiple	Kahler-Bozzolo Disease
Plasma Cell Myelomas	MM
Plasma Cell Neoplasm	Primary Systemic Amyloidosis
Primary Amyloidosis	Immunoglobulin Deposition Disease
Plasmacytic Myeloma	Multiple Myelomata
Multiple Myeloma Nos	Multiple Myeloma Without Mention Of Remission
Monostotic Plasma Cell Myeloma	Mm - [Multiple Myeloma]

Mcd Diffuse Large B-Cell Lymphoma

Mcd Dlbcl

Doid:0081066

Weaver Syndrome

Wss	Weaver-Smith Syndrome
WVS	Weaver-Like Syndrome
Weaver-Williams Syndrome	Camptodactyly-Overgrowth-Unusual Facies Syndrome
Camptodactyly - Overgrowth - Unusual Facies	Ezh2 Related Overgrowth
Overgrowth Syndrome With Accelerated Skeletal Maturation, Unusual Facies, And Camptodactyly	Weaver Smith Syndrome
Weaver Like Syndrome	Weaver Williams Syndrome
Camptodactyly-Overgrowth-Unusual Facies	Weaver Syndrome 1
Weaver Syndrome 2	Wvs1
Wvs2

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10587	BIX-01294		98.44%	Unkown
HY-108239	BIX-01294 trihydrochloride		/	Unkown
HY-RS05949	H1-4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-N1682	2,7-Dihydroxy-2H-1,4-benzoxazin-3(4H)-one		/	Unkown
HY-W781963	7-Bromo-5-(2-fluorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one	Control	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	H1-4	VGNC	VGNC:109858
Bos taurus	H1-4	VGNC	VGNC:83559
Macaca mulatta	H1-4	VGNC	VGNC:109744
Mus musculus	H1-4	MGD	MGI:1931527
Canis familiaris	H1-4	VGNC	VGNC:83756
Rattus norvegicus	H1-4	RGD	RGD:2776

Name
Email *

	Sorry, but the email address you supplied was invalid.