SMURF1 - SMAD specific E3 ubiquitin protein ligase 1 Gene

Homo sapiens

Gene ID: 57154 | Gene type: protein coding

About SMURF1

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:99,027,440-99,144,108 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 206 orthologues and 24 paralogues. Ubiquitous expression in testis (RPKM 21.9), stomach (RPKM 11.7) and 25 other tissues.

Summary

This gene encodes a ubiquitin Ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2010]

SMURF1 Products(3)

mRNA	Protein	Name
NM_001199847.2	NP_001186776.1	E3 ubiquitin-protein ligase SMURF1 isoform 3
NM_020429.3	NP_065162.1	E3 ubiquitin-protein ligase SMURF1 isoform 1
NM_181349.3	NP_851994.1	E3 ubiquitin-protein ligase SMURF1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables I-SMAD binding	IPI IPI: Inferred from physical interaction	11278251	GOA
enables R-SMAD binding	IPI IPI: Inferred from physical interaction	11278251	GOA
enables activin receptor binding	IPI IPI: Inferred from physical interaction	16720724	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15231748	GOA
enables transforming growth factor beta receptor binding	IPI IPI: Inferred from physical interaction	12151385	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	11278251	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	10458166	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in BMP signaling pathway	IDA IDA: Inferred from direct assay	21572392	GOA
involved in cell differentiation	IDA IDA: Inferred from direct assay	10458166	GOA
involved in engulfment of target by autophagosome	IMP IMP: Inferred from mutant phenotype	22020285	GOA
involved in negative regulation of BMP signaling pathway	IDA IDA: Inferred from direct assay	27214554	GOA
involved in negative regulation of activin receptor signaling pathway	IDA IDA: Inferred from direct assay	16720724	GOA
involved in negative regulation of transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	11278251	GOA
involved in negative regulation of transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	21791611	GOA
involved in positive regulation of dendrite extension	IDA IDA: Inferred from direct assay	23999003	GOA
involved in positive regulation of ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	21454619	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	11278251	GOA
involved in protein export from nucleus	IDA IDA: Inferred from direct assay	11278251	GOA
involved in protein localization to plasma membrane	IDA IDA: Inferred from direct assay	12151385	GOA
involved in protein polyubiquitination	IDA IDA: Inferred from direct assay	11278251	GOA
involved in protein targeting to vacuole involved in autophagy	IMP IMP: Inferred from mutant phenotype	22020285	GOA
involved in receptor catabolic process	IDA IDA: Inferred from direct assay	12151385	GOA
involved in substrate localization to autophagosome	IMP IMP: Inferred from mutant phenotype	22020285	GOA
involved in ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	10458166	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11278251	GOA
colocalizes with mitochondrion	IGI IGI: Inferred from genetic interaction	22020285	GOA
is active in plasma membrane	IDA IDA: Inferred from direct assay	12151385	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SMURF1 Protein Structure

HECT

0
200
400
600
757 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase SMURF1

E3 ubiquitin ligase SMURF1

SMURF1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SMURF1	Q9HCE7	SMAD1	Homo sapiens	Q15797	Anti Tag CoIP	19914168
Intra	SMURF1	Q9HCE7	SMAD1	Homo sapiens	Q15797	Y2H	15231748
Intra	SMURF1	Q9HCE7	PSME3	Homo sapiens	P61289	Y2H	20580715
Intra	SMURF1	Q9HCE7	PSME3	Homo sapiens	P61289	Pull Down	20580715
Intra	SMURF1	Q9HCE7	PSME3	Homo sapiens	P61289	Anti Tag CoIP	20580715
Intra	SMURF1	Q9HCE7	FBXL15	Homo sapiens	Q9H469	Y2H	21572392
Intra	SMURF1	Q9HCE7	FBXL15	Homo sapiens	Q9H469	Anti Tag CoIP	21572392
Intra	SMURF1	Q9HCE7	FBXL15	Homo sapiens	Q9H469	Anti Bait CoIP	21572392
Intra	SMURF1	Q9HCE7	PLEKHO1	Homo sapiens	Q53GL0	Pull Down	20580715
Intra	SMURF1	Q9HCE7	PLEKHO1	Homo sapiens	Q53GL0	Pull Down	23032291
Intra	SMURF1	Q9HCE7	KLF2	Homo sapiens	Q9Y5W3	Y2H	21382345

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Geotrichosis

Brachydactyly, Type A2

Brachydactyly Type A2	BDA2
Mohr-Wriedt Type Brachydactyly	Brachymesophalangy Ii
Brachymesophalangy Type 2	Brachymesophalangy 2
Brachydactyly, Mohr-Wriedt Type	Brachydactyly A2

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-110195	Smurf1-IN-A01		99.81%	Unkown
HY-149316	Smurf1-IN-1	Inhibitor	99.47%	Unkown
HY-160928	Smurf1 modulator-1	Inhibitor	99.76%	Unkown
HY-W998345	SMART1	Inhibitor	99.31%	Unkown
HY-169049	Smurf1 ligand 1		/	Unkown
HY-RS13459	SMURF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SMURF1	VGNC	VGNC:77726
Rattus norvegicus	SMURF1	RGD	RGD:1594738
Mus musculus	SMURF1	MGD	MGI:1923038
Felis catus	SMURF1	VGNC	VGNC:65510
Bos taurus	SMURF1	VGNC	VGNC:35040
Canis familiaris	SMURF1	VGNC	VGNC:46580

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