SMURF1 - SMAD specific E3 ubiquitin protein ligase 1 Gene

Homo sapiens

Gene ID: 57154 | Gene type: protein coding

About SMURF1

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:99,027,440-99,144,108 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 206 orthologues and 24 paralogues. Ubiquitous expression in testis (RPKM 21.9), stomach (RPKM 11.7) and 25 other tissues.

Summary

This gene encodes a ubiquitin Ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2010]

SMURF1 Products(3)

mRNA	Protein	Name
NM_001199847.2	NP_001186776.1	E3 ubiquitin-protein ligase SMURF1 isoform 3
NM_020429.3	NP_065162.1	E3 ubiquitin-protein ligase SMURF1 isoform 1
NM_181349.3	NP_851994.1	E3 ubiquitin-protein ligase SMURF1 isoform 2

SMURF1 Protein Structure

HECT

0
200
400
600
757 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase SMURF1

E3 ubiquitin ligase SMURF1

Related Diseases

Diseases

Alias

Geotrichosis

Brachydactyly, Type A2

Brachydactyly Type A2	BDA2
Mohr-Wriedt Type Brachydactyly	Brachymesophalangy Ii
Brachymesophalangy Type 2	Brachymesophalangy 2
Brachydactyly, Mohr-Wriedt Type	Brachydactyly A2

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-110195	Smurf1-IN-A01		99.81%	Unkown
HY-149316	Smurf1-IN-1	Inhibitor	99.47%	Unkown
HY-RS13459	SMURF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W998345	SMART1	Inhibitor	/	Unkown
HY-160928	Smurf1 modulator-1	Inhibitor	99.76%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SMURF1	VGNC	VGNC:77726
Rattus norvegicus	SMURF1	RGD	RGD:1594738
Mus musculus	SMURF1	MGD	MGI:1923038
Felis catus	SMURF1	VGNC	VGNC:65510
Bos taurus	SMURF1	VGNC	VGNC:35040
Canis familiaris	SMURF1	VGNC	VGNC:46580

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