PSMD13 - proteasome 26S subunit, non-ATPase 13 Gene

Homo sapiens

Also known as S11; Rpn9; p40.5; HSPC027

Gene ID: 5719 | Gene type: protein coding

About PSMD13

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:236,976-252,984 (from NCBI)

This gene has 14 transcripts (splice variants) and 218 orthologues. Ubiquitous expression in appendix (RPKM 33.3), lymph node (RPKM 32.2) and 25 other tissues.

Summary

The 26S Proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave Peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified Proteasome, the immunoproteasome, is the processing of class I MHC Peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Two transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

PSMD13 Products(2)

mRNA	Protein	Name
NM_002817.4	NP_002808.3	26S proteasome non-ATPase regulatory subunit 13 isoform 1
NM_175932.3	NP_787128.2	26S proteasome non-ATPase regulatory subunit 13 isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16990800	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of proteasome complex	IDA IDA: Inferred from direct assay	17323924	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSMD13 Protein Structure

PCI

0
100
200
300
376 a.a.

Protein Preferred Names

Protein Names

26S proteasome non-ATPase regulatory subunit 13

26S proteasome regulatory subunit RPN9

PSMD13 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PSMD13	Q9UNM6	PSMD4	Homo sapiens	P55036	Anti Tag CoIP	33961781
Intra	PSMD13	Q9UNM6	PSMD4	Homo sapiens	P55036	Anti Bait CoIP	17353931

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Histrionic Personality Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11321	PSMD13 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PSMD13	MGD	MGI:1345192
Canis familiaris	PSMD13	VGNC	VGNC:45109
Bos taurus	PSMD13	VGNC	VGNC:33464
Felis catus	PSMD13	VGNC	VGNC:69121
Rattus norvegicus	PSMD13	RGD	RGD:1305236
Macaca mulatta	PSMD13	VGNC	VGNC:101386

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