2. Gene
  3. SENP7 - SUMO specific peptidase 7 Gene

SENP7 - SUMO specific peptidase 7 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 57337 | Gene type: protein coding

About SENP7

Cytogenetic location: 3q12.3 Genomic coordinates (GRCh38): 3:101,324,205-101,513,212 (from NCBI)

This gene has 8 transcripts (splice variants), 267 orthologues and 1 paralogue. Ubiquitous expression in endometrium (RPKM 9.0), lymph node (RPKM 7.6) and 25 other tissues.

Summary

The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for many cellular processes. SUMO-specific proteases, such as SENP7, process SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009]

SENP7 Products(6)

mRNA Protein Name
NM_001077203.3 NP_001070671.1 sentrin-specific protease 7 isoform 2
NM_001282801.2 NP_001269730.1 sentrin-specific protease 7 isoform 3
NM_001282802.2 NP_001269731.1 sentrin-specific protease 7 isoform 4
NM_001282803.2 NP_001269732.1 sentrin-specific protease 7 isoform 5
NM_001282804.2 NP_001269733.1 sentrin-specific protease 7 isoform 6
NM_020654.5 NP_065705.3 sentrin-specific protease 7 isoform 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
20562864 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SENP7 Protein Structure

Peptidase_C48

Peptidase_C48: Ulp1 protease family, C-terminal catalytic domain (774 - 1015)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1050 a.a.
Protein Preferred Names Protein Names

sentrin-specific protease 7

SUMO-1-specific protease 2

SENP7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SENP7 Q9BQF6 TRIM28 Homo sapiens Q13263
TAP
27705803
Intra
SENP7 Q9BQF6 TRIM28 Homo sapiens Q13263
Anti Tag CoIP
24018422
Intra
SENP7 Q9BQF6 CBX5 Homo sapiens P45973
Anti Tag CoIP
24018422
Intra
SENP7 Q9BQF6 CBX5 Homo sapiens P45973
TAP
27705803
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SENP7 Proteins

Cat. No. Product Name Accession Purity
HY-P71289 SENP7 Protein, Human Q9BQF6-1 (M695-A864) ≥95%

Related Diseases

Diseases Alias
Malaria

Malaria, Susceptibility To

Malaria, Resistance To

Malaria, Cerebral

Cerebral Malaria

Malaria, Severe, Susceptibility To

Malaria, Severe, Resistance To

Malaria, Cerebral, Susceptibility To

Induced Malaria

Malaria, Vivax, Protection Against

Malaria, Severe

Malaria, Cerebral, Reduced Risk Of

Malaria, Protection Against

Resistance To Malaria Due To G6pd Deficiency

Malaria Due To G6pd Deficiency

Malarial Encephalitis

CM

Malaria Cerebral

Susceptibility To Malaria

Acute Pernicious Fever

Aestivo-Autumnal Fever

Aestivo Autumnal Malaria

Chagres Fever

Continued Malaria Fever

Estivo-Autumnal Fever

Estivo-Autumnal Malaria

Estivo-Autumnal Malarial Fever

Falciparum Fever

Malignant Tertian Fever

Malignant Tertian Malaria

Pernicious Intermittent Fever

Pernicious Malaria

Quotidian Malaria

Subtertian Fever

Subtertian Malaria Fever

Subtertian Malignant Tertian Malaria

Tropical Malaria

Algid Malaria

Bilious Haemoglobinuric Fever

Black Water Fever

Blackwater Fever

Malarial Blackwater Fever

Severe Malarial Falciparum

West African Fever

Malarial Haematinuria

Haemoglobinuric Fever

Haemoglobinuric Malaria

Severe Plasmodium Falciparum Malaria

Malarial Haemoglobinuria

Malarial Haematuria

Falciparum Malaria [Malignant Tertian]

Malaria Tropica

Malarial Shock

Chagres Virus Disease

Malignant Malaria

Mtm - [Malignant Tertian Malaria]

Tm -[Malignant Tertian Malaria]

Panama Fever

St - [Subtertian Malaria]

Malarial Quotidian

Benign Tertian Malaria

Tertian Ague

Vivax Fever

Plasmodium Vivax Malaria Nos

Btm - [Benign Tertian Malaria]

Bt - [Benign Tertian Malaria]

Vivax Malaria

Benign Tertian Vivax Malaria

Tertian Malaria

Quartan Malaria

Quartan Ague

Quartan Fever

Plasmodium Malariae Malaria Nos

Quartan Malarial

Malaria By Plasmodium Malariae

Malariae Malaria

Ovale Tertian Malaria

Plasmodium Ovale Fever

Malaria Fever By Plasmodium Ovale

Ovale Malaria

Malaria By Plasmodium Ovale

Malarial Ovale

Marsh Fever

Remittent Congestive Fever

Coastal Fever

Remittent Gastric Fever

Miasmatic Fever

Congestive Remittent Fever

Intermittent Fever

Jungle Fever

Paludism

Cameroon Fever

Ague

Corsican Fever

Intermittent Bilious Fever

Disease Due To Plasmodiidae

Malarial Fever

Plasmodiosis

Remittent Fever

Roman Fever

Malaria Fever Nos

Malaria Nos

Paludal Fever

Clinically Diagnosed Malaria

Clinically Diagnosed Malaria Without Parasitological Confirmation

Congestive Fever

Malarial Cachexia

Marsh Cachexia

Paludal Cachexia

Recurrent Malaria

Remittent Malaria
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12676 SENP7 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SENP7 VGNC VGNC:52825
Canis familiaris SENP7 VGNC VGNC:53087
Macaca mulatta SENP7 VGNC VGNC:77346
Felis catus SENP7 VGNC VGNC:65005
Rattus norvegicus SENP7 RGD RGD:1305510
Mus musculus SENP7 MGD MGI:1913565
Others SENP7 NCBI