SCYL1 - SCY1 like pseudokinase 1 Gene

Homo sapiens

Also known as GKLP; NKTL; NTKL; P105; TAPK; TEIF; TRAP; HT019; SCAR21

Gene ID: 57410 | Gene type: protein coding

About SCYL1

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:65,525,083-65,538,704 (from NCBI)

This gene has 14 transcripts (splice variants), 183 orthologues, 2 paralogues and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 23.2), ovary (RPKM 22.4) and 25 other tissues.

Summary

This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase Reverse Transcriptase and DNA Polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during mitosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

SCYL1 Products(3)

mRNA	Protein	Name
NM_001048218.2	NP_001041683.1	N-terminal kinase-like protein isoform B
NM_001411022.1	NP_001397951.1	N-terminal kinase-like protein isoform C
NM_020680.4	NP_065731.3	N-terminal kinase-like protein isoform A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	26871637	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IDA IDA: Inferred from direct assay	18556652	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of COPI vesicle coat	IDA IDA: Inferred from direct assay	18556652	GOA
located in Golgi apparatus	IDA IDA: Inferred from direct assay	18556652	GOA
located in cis-Golgi network	IDA IDA: Inferred from direct assay	18556652	GOA
located in endoplasmic reticulum-Golgi intermediate compartment	IDA IDA: Inferred from direct assay	18556652	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCYL1 Protein Structure

Pkinase

0
200
400
600
808 a.a.

Protein Preferred Names

Protein Names

N-terminal kinase-like protein

SCY1-like protein 1

SCYL1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SCYL1	Q96KG9	SEC31A	Homo sapiens	O94979	Pull Down	32707033
Intra	SCYL1	Q96KG9	SEC31A	Homo sapiens	O94979	Anti Tag CoIP	35271311
Intra	SCYL1	Q96KG9	SEC31A	Homo sapiens	O94979	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Spinocerebellar Ataxia, Autosomal Recessive 21

SCAR21	Acute Infantile Liver Failure-Cerebellar Ataxia-Peripheral Sensory Motor Neuropathy Syndrome
Spinocerebellar Ataxia, Autosomal Recessive 21, With Hepatopathy	Cholestasis, Low Ggt, Acute Liver Failure, And Neurodegeneration Syndrome
Calfan	Autosomal Recessive Spinocerebellar Ataxia 21
Autosomal Recessive Spinocerebellar Ataxia 21 With Hepatopathy	Autosomal Recessive Spinocerebellar Ataxia Type 21
Spinocerebellar Ataxia, Autosomal Recessive, 21	Calfan Syndrome

Spinocerebellar Ataxia 21

Spinocerebellar Ataxia Type 21	SCA21
Ataxia, Spinocerebellar, Type 21

Geroderma Osteodysplasticum

Gerodermia Osteodysplastica	Geroderma Osteodysplastica
GO	Walt Disney Dwarfism
Type Of Gerodermia Osteodysplastica

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12575	SCYL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SCYL1	MGD	MGI:1931787
Bos taurus	SCYL1	VGNC	VGNC:34374
Rattus norvegicus	SCYL1	RGD	RGD:1307330
Canis familiaris	SCYL1	VGNC	VGNC:45938
Felis catus	SCYL1	VGNC	VGNC:64940
Others	SCYL1	NCBI

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