2. Gene
  3. SEC31A - SEC31 homolog A, COPII coat complex component Gene

SEC31A - SEC31 homolog A, COPII coat complex component Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HPBKS; ABP125; ABP130; HSPC275; HSPC334; NEDSOSB; SEC31L1

Gene ID: 22872 | Gene type: protein coding

About SEC31A

Cytogenetic location: 4q21.22 Genomic coordinates (GRCh38): 4:82,818,509-82,900,569 (from NCBI)

This gene has 41 transcripts (splice variants), 208 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in ovary (RPKM 48.8), thyroid (RPKM 42.6) and 25 other tissues.

Summary

The protein encoded by this gene shares similarity with the yeast Sec31 protein, and is a component of the outer layer of the coat protein complex II (COPII). The encoded protein is involved in vesicle budding from the endoplasmic reticulum (ER) and contains multiple WD repeats near the N-terminus and a proline-rich region in the C-terminal half. It associates with the protein encoded by the SEC13 homolog, nuclear pore and COPII coat complex component (SEC13), and is required for ER-Golgi transport. Monoubiquitylation of this protein by CUL3-KLHL12 was found to regulate the size of COPII coats to accommodate unusually shaped cargo. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

SEC31A Products(57)

mRNA Protein Name
NM_001077206.4 NP_001070674.1 protein transport protein Sec31A isoform 4
NM_001077207.4 NP_001070675.1 protein transport protein Sec31A isoform 1
NM_001077208.4 NP_001070676.1 protein transport protein Sec31A isoform 3
NM_001191049.2 NP_001177978.1 protein transport protein Sec31A isoform 5
NM_001300744.3 NP_001287673.1 protein transport protein Sec31A isoform 6
NM_001300745.3 NP_001287674.1 protein transport protein Sec31A isoform 7
NM_001318119.2 NP_001305048.1 protein transport protein Sec31A isoform 3
NM_001318120.2 NP_001305049.1 protein transport protein Sec31A isoform 1
NM_001400154.1 NP_001387083.1 protein transport protein Sec31A isoform 8
NM_001400155.1 NP_001387084.1 protein transport protein Sec31A isoform 8
NM_001400156.1 NP_001387085.1 protein transport protein Sec31A isoform 9
NM_001400157.1 NP_001387086.1 protein transport protein Sec31A isoform 10
NM_001400158.1 NP_001387087.1 protein transport protein Sec31A isoform 10
NM_001400159.1 NP_001387088.1 protein transport protein Sec31A isoform 10
NM_001400160.1 NP_001387089.1 protein transport protein Sec31A isoform 11
NM_001400161.1 NP_001387090.1 protein transport protein Sec31A isoform 32
NM_001400162.1 NP_001387091.1 protein transport protein Sec31A isoform 12
NM_001400164.1 NP_001387093.1 protein transport protein Sec31A isoform 1
NM_001400165.1 NP_001387094.1 protein transport protein Sec31A isoform 14
NM_001400166.1 NP_001387095.1 protein transport protein Sec31A isoform 1
NM_001400167.1 NP_001387096.1 protein transport protein Sec31A isoform 15
NM_001400168.1 NP_001387097.1 protein transport protein Sec31A isoform 15
NM_001400180.1 NP_001387109.1 protein transport protein Sec31A isoform 16
NM_001400184.1 NP_001387113.1 protein transport protein Sec31A isoform 17
NM_001400186.1 NP_001387115.1 protein transport protein Sec31A isoform 17
NM_001400188.1 NP_001387117.1 protein transport protein Sec31A isoform 16
NM_001400190.1 NP_001387119.1 protein transport protein Sec31A isoform 3
NM_001400191.1 NP_001387120.1 protein transport protein Sec31A isoform 3
NM_001400193.1 NP_001387122.1 protein transport protein Sec31A isoform 3
NM_001400194.1 NP_001387123.1 protein transport protein Sec31A isoform 18
NM_001400197.1 NP_001387126.1 protein transport protein Sec31A isoform 19
NM_001400198.1 NP_001387127.1 protein transport protein Sec31A isoform 20
NM_001400200.1 NP_001387129.1 protein transport protein Sec31A isoform 19
NM_001400202.1 NP_001387131.1 protein transport protein Sec31A isoform 20
NM_001400203.1 NP_001387132.1 protein transport protein Sec31A isoform 19
NM_001400204.1 NP_001387133.1 protein transport protein Sec31A isoform 21
NM_001400205.1 NP_001387134.1 protein transport protein Sec31A isoform 21
NM_001400206.1 NP_001387135.1 protein transport protein Sec31A isoform 21
NM_001400207.1 NP_001387136.1 protein transport protein Sec31A isoform 2
NM_001400208.1 NP_001387137.1 protein transport protein Sec31A isoform 22
NM_001400209.1 NP_001387138.1 protein transport protein Sec31A isoform 2
NM_001400210.1 NP_001387139.1 protein transport protein Sec31A isoform 23
NM_001400211.1 NP_001387140.1 protein transport protein Sec31A isoform 23
NM_001400212.1 NP_001387141.1 protein transport protein Sec31A isoform 24
NM_001400213.1 NP_001387142.1 protein transport protein Sec31A isoform 7
NM_001400214.1 NP_001387143.1 protein transport protein Sec31A isoform 25
NM_001400215.1 NP_001387144.1 protein transport protein Sec31A isoform 26
NM_001400216.1 NP_001387145.1 protein transport protein Sec31A isoform 27
NM_001400217.1 NP_001387146.1 protein transport protein Sec31A isoform 4
NM_001400218.1 NP_001387147.1 protein transport protein Sec31A isoform 28
NM_001400219.1 NP_001387148.1 protein transport protein Sec31A isoform 29
NM_001400220.1 NP_001387149.1 protein transport protein Sec31A isoform 29
NM_001400221.1 NP_001387150.1 protein transport protein Sec31A isoform 30
NM_001400222.1 NP_001387151.1 protein transport protein Sec31A isoform 30
NM_001400223.1 NP_001387152.1 protein transport protein Sec31A isoform 6
NM_001400224.1 NP_001387153.1 protein transport protein Sec31A isoform 31
NM_016211.5 NP_057295.2 protein transport protein Sec31A isoform 2

SEC31A Protein Structure

WD40

WD40: WD domain, G-beta repeat (251 - 285)

Sec16_C

Sec16_C: Sec23-binding domain of Sec16 (573 - 766)

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  • 1220 a.a.
Protein Preferred Names Protein Names

protein transport protein Sec31A

SEC31 homolog A, COPII coating complex component

Related Diseases

Diseases Alias
Halperin-Birk Syndrome

Neurodevelopmental Disorder With Spastic Quadriplegia, Optic Atrophy, Seizures, And Structural Brain Anomalies

NEDSOSB

HLBKS
Pseudobulbar Palsy

Pseudobulbar Paralysis
Spastic Quadriplegia

Spastic Quadriplegic Cerebral Palsy

Quadriplegic Infantile Cerebral Palsy

Tetraplegic Infantile Cerebral Palsy

Cerebral Palsy Spastic Quadriplegic

Quadriplegic Cerebral Palsy

Spastic Quadriplegia Cerebral Palsy

Spastic Tetraplegia Cerebral Palsy

Cerebral Palsy, Quadriplegic, Infantile

Cerebral Palsy With Spastic Tetraplegia

Congenital Spastic Quadriplegia

Spastic Tetraplegic Cerebral Palsy

Congenital Quadriplegia Nos

Tetraplegic Cerebral Palsy
Epithelioid Inflammatory Myofibroblastic Sarcoma
Quadriplegia

Tetraplegia

Tetraplegias
Semilobar Holoprosencephaly
Inflammatory Myofibroblastic Tumor

Inflammatory Fibrosarcoma
Craniolenticulosutural Dysplasia

Boyadjiev-Jabs Syndrome

CLSD

Cranio-Lenticulo-Sutural Dysplasia

Cranio-Lenticulo-Sutural Dysplasia, Clsd
Chylomicron Retention Disease

CMRD

Anderson Disease

Lipid Transport Defect Of Intestine

Hypobetalipoproteinemia With Accumulation Of Apolipoprotein B-Like Protein In Intestinal Cells

Andd

Anderson Syndrome

Crd

Andersons Disease

Malabsorption Syndrome
Holoprosencephaly

Holoprosencephaly Sequence

Hpe

Hpe - [Holoprosencephaly]
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12619 SEC31A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SEC31A VGNC VGNC:77256
Bos taurus SEC31A VGNC VGNC:34417
Felis catus SEC31A VGNC VGNC:64971
Rattus norvegicus SEC31A RGD RGD:620233
Canis familiaris SEC31A VGNC VGNC:45976
Mus musculus SEC31A MGD MGI:1916412