ZNF512B - zinc finger protein 512B Gene

Homo sapiens

Also known as GM632

Gene ID: 57473 | Gene type: protein coding

About ZNF512B

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:63,956,704-63,969,930 (from NCBI)

This gene has 1 transcript (splice variant), 208 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 5.4), thyroid (RPKM 5.3) and 25 other tissues.

Summary

Predicted to enable DNA binding activity and metal ion binding activity. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ZNF512B Products(1)

mRNA	Protein	Name
NM_020713.3	NP_065764.1	zinc finger protein 512B

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	20639536	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	20639536	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of miRNA transcription	IDA IDA: Inferred from direct assay	20639536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF512B Protein Structure

zf-C2H2_4

0
200
400
600
800
892 a.a.

Protein Preferred Names

Protein Names

zinc finger protein 512B

Related Diseases

Diseases

Alias

Deafness, Autosomal Dominant 40

DFNA40	Autosomal Dominant Nonsyndromic Deafness 40
Autosomal Dominant Deafness 40	Deafness, Autosomal Dominant, 40
Deafness, Autosomal Dominant, Type 40

Nut Allergy

Nut Allergic Reaction	Nut Hypersensitivity
Allergy To Nuts	Allergy Nut

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16150	ZNF512B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ZNF512B	RGD	RGD:1305284
Canis familiaris	ZNF512B	VGNC	VGNC:48744
Felis catus	ZNF512B	VGNC	VGNC:67316
Mus musculus	ZNF512B	MGD	MGI:2685478
Macaca mulatta	ZNF512B	VGNC	VGNC:79788
Bos taurus	ZNF512B	VGNC	VGNC:37291

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