ZNF143 - zinc finger protein 143 Gene

Homo sapiens

Also known as SBF; STAF; pHZ-1

Gene ID: 7702 | Gene type: protein coding

About ZNF143

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:9,461,012-9,528,524 (from NCBI)

This gene has 18 transcripts (splice variants), 220 orthologues and 36 paralogues. Ubiquitous expression in testis (RPKM 5.8), lymph node (RPKM 4.3) and 25 other tissues.

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of snRNA transcription by RNA polymerase II. Predicted to be located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ZNF143 Products(3)

mRNA	Protein	Name
NM_001282656.2	NP_001269585.1	zinc finger protein 143 isoform 2
NM_001282657.2	NP_001269586.1	zinc finger protein 143 isoform 3
NM_003442.6	NP_003433.3	zinc finger protein 143 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	10893243	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10893243	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17938208	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of snRNA transcription by RNA polymerase II	EXP EXP: Inferred from Experiment	9009278	GOA
involved in positive regulation of transcription by RNA polymerase II	EXP EXP: Inferred from Experiment	9009278	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10893243	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF143 Protein Structure

zf-H2C2_2

zf-C2H2

0
100
200
300
400
500
600
638 a.a.

Protein Preferred Names

Protein Names

zinc finger protein 143

SPH-binding factor

ZNF143 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZNF143	P52747	IQUB	Homo sapiens	Q8NA54	Validated Y2H	32296183
Intra	ZNF143	P52747	NUDT22	Homo sapiens	Q9BRQ3	Validated Y2H	32296183
Intra	ZNF143	P52747	YJU2	Homo sapiens	Q9BW85	Validated Y2H	32296183
Intra	ZNF143	P52747	ZNF512B	Homo sapiens	Q96KM6	Validated Y2H	32296183
Intra	ZNF143	P52747	LMO3	Homo sapiens	Q8TAP4-4	Validated Y2H	32296183
Intra	ZNF143	P52747	ZNF438	Homo sapiens	Q7Z4V0	Validated Y2H	32296183
Intra	ZNF143	P52747	ZNF438	Homo sapiens	Q7Z4V0	Y2H Prey Pooling	32296183
Intra	ZNF143	P52747	TCAF1	Homo sapiens	Q9Y4C2-2	Validated Y2H	32296183
Intra	ZNF143	P52747	SPANXN3	Homo sapiens	Q5MJ09	Validated Y2H	32296183
Intra	ZNF143	P52747	LIN54	Homo sapiens	Q6MZP7	Validated Y2H	32296183
Intra	ZNF143	P52747	IL16	Homo sapiens	Q14005-2	Validated Y2H	32296183
Intra	ZNF143	P52747	TAB2	Homo sapiens	Q9NYJ8	Validated Y2H	32296183
Intra	ZNF143	P52747	EXOSC1	Homo sapiens	Q9Y3B2	Validated Y2H	32296183
Intra	ZNF143	P52747	FAM90A1	Homo sapiens	Q86YD7	Validated Y2H	32296183
Intra	ZNF143	P52747	FHL2	Homo sapiens	Q14192	Validated Y2H	32296183
Intra	ZNF143	P52747	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	32296183
Intra	ZNF143	P52747	EAF1	Homo sapiens	Q96JC9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Disorders Of Intracellular Cobalamin Metabolism

Spherocytosis, Type 5

Hereditary Spherocytosis Type 5	SPH5
Hs5	Spherocytosis, Hereditary, 5
Hereditary Spherocytosis 5	Spherocytosis 5
Spherocytosis, Hereditary, Type 5

Basilar Artery Insufficiency

Basilar Artery Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16103	ZNF143 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-120264	YPC-22026		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ZNF143	VGNC	VGNC:81612
Rattus norvegicus	ZNF143	RGD	RGD:1305662
Mus musculus	ZNF143	MGD	MGI:1277969
Canis familiaris	ZNF143	VGNC	VGNC:48661
Felis catus	ZNF143	VGNC	VGNC:67268
Bos taurus	ZNF143	VGNC	VGNC:58348

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