MTA3 - metastasis associated 1 family member 3 Gene

Homo sapiens

Gene ID: 57504 | Gene type: protein coding

About MTA3

Cytogenetic location: 2p21 Genomic coordinates (GRCh38): 2:42,494,110-42,756,946 (from NCBI)

This gene has 19 transcripts (splice variants), 209 orthologues and 5 paralogues. Ubiquitous expression in brain (RPKM 6.3), ovary (RPKM 5.7) and 24 other tissues.

Summary

Predicted to enable histone deacetylase binding activity; transcription coactivator activity; and transcription corepressor activity. Involved in negative regulation of transcription, DNA-templated. Located in nucleoplasm. Part of NuRD complex. [provided by Alliance of Genome Resources, Apr 2022]

MTA3 Products(6)

mRNA	Protein	Name
NM_001282755.2	NP_001269684.1	metastasis-associated protein MTA3 isoform a
NM_001282756.2	NP_001269685.1	metastasis-associated protein MTA3 isoform a
NM_001330442.2	NP_001317371.1	metastasis-associated protein MTA3 isoform c
NM_001330443.2	NP_001317372.1	metastasis-associated protein MTA3 isoform d
NM_001330444.2	NP_001317373.1	metastasis-associated protein MTA3 isoform e
NM_020744.4	NP_065795.1	metastasis-associated protein MTA3 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22926524	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in chromatin remodeling	IDA IDA: Inferred from direct assay	9790534	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	15454082	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of NuRD complex	IDA IDA: Inferred from direct assay	22926524	GOA
located in nucleus	IDA IDA: Inferred from direct assay	28977666	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MTA3 Protein Structure

BAH

ELM2

GATA

0
100
200
300
400
500
594 a.a.

Protein Preferred Names

Protein Names

metastasis-associated protein MTA3

metastasis associated gene family, member 3

MTA3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MTA3	Q9BTC8	GATA3	Homo sapiens	P23771	Anti Bait CoIP	26028330
Intra	MTA3	Q9BTC8	GATA3	Homo sapiens	P23771	Anti Tag CoIP	26028330
Intra	MTA3	Q9BTC8	GATA3	Homo sapiens	P23771	CH-IP	26028330
Intra	MTA3	Q9BTC8	EHMT2	Homo sapiens	Q96KQ7	Anti Tag CoIP	26028330
Intra	MTA3	Q9BTC8	EHMT2	Homo sapiens	Q96KQ7	Pull Down	26028330
Intra	MTA3	Q9BTC8	EHMT2	Homo sapiens	Q96KQ7	Anti Bait CoIP	26028330
Intra	MTA3	Q9BTC8	EHMT2	Homo sapiens	Q96KQ7	CH-IP	26028330

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Pyloric Stenosis

Hutchinson-Gilford Progeria Syndrome

Progeria	HGPS
Hutchinson-Gilford Syndrome	Hutchinson-Gilford Progeria
Hutchinson Gilford Syndrome	Hutchinson Gilford Progeria Syndrome
Hutchinson-Gilford Disease	Progeria Of Childhood
Hutchinson-Gilford-Progeria Syndrome

Hypertrophic Pyloric Stenosis

Congenital Hypertrophic Pyloric Stenosis	Pyloric Stenosis, Hypertrophic
Congenital Or Infantile Stricture Of Pylorus	Achalasia Of The Pylorus
Congenital Hypertrophy Of The Pylorus	Infantile Hypertrophy Of The Pylorus
Infantile Constriction Of The Pylorus	Congenital Stenosis Of The Pylorus
Congenital Constriction Of The Pylorus	Congenital Stricture Of The Pylorus
Infantile Hypertrophic Pyloric Stenosis	Infantile Stenosis Of The Pylorus
Infantile Stricture Of The Pylorus	Congenital Or Infantile Constriction Of Pylorus
Infantile Pyloric Obstruction	Infantile Pyloric Hypertrophy
Pylorus Achalasia	Pyloric Constriction
Infantile Pyloric Stricture	Infantile Pyloric Stenosis
Congenital Spasm Of Pylorus	Congenital Pylorospasm
Congenital Pyloric Stricture	Congenital Pyloric Spasm
Congenital Or Infantile Spasm Of Pylorus	Congenital Or Infantile Obstruction Of Pylorus
Congenital Pyloric Stenosis

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08748	MTA3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MTA3	VGNC	VGNC:31715
Macaca mulatta	MTA3	VGNC	VGNC:74814
Felis catus	MTA3	VGNC	VGNC:63640
Rattus norvegicus	MTA3	RGD	RGD:1306803
Mus musculus	MTA3	MGD	MGI:2151172

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