2. Gene
  3. CGN - cingulin Gene

CGN - cingulin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 57530 | Gene type: protein coding

About CGN

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:151,510,170-151,538,692 (from NCBI)

This gene has 8 transcripts (splice variants), 171 orthologues and 43 paralogues. Broad expression in small intestine (RPKM 30.7), duodenum (RPKM 28.7) and 15 other tissues.

Summary

Enables cadherin binding activity. Predicted to act upstream of or within bicellular tight junction assembly; epithelial cell morphogenesis; and microtubule Cytoskeleton organization. Located in bicellular tight junction and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

CGN Products(1)

mRNA Protein Name
NM_020770.3 NP_065821.1 cingulin
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
11042084 GOA
Cellular Component GO Annotation Evidence Reference Source
located in bicellular tight junction IDA
IDA: Inferred from direct assay
22006950 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CGN Protein Structure

Myosin_tail_1

Myosin_tail_1: Myosin tail (816 - 1152)

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  • 1203 a.a.
Protein Preferred Names Protein Names

cingulin

CGN Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CGN Q9P2M7 YWHAZ Homo sapiens P63104
Pull Down
15161933
Intra
CGN Q9P2M7 YWHAZ Homo sapiens P63104
Anti Tag CoIP
28514442
Intra
CGN Q9P2M7 YWHAZ Homo sapiens P63104
Anti Tag CoIP
33961781
Intra
CGN Q9P2M7 SFN Homo sapiens P31947
TAP
15778465
Intra
CGN Q9P2M7 TJP1 Homo sapiens Q07157
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-111793A NUCC-390 dihydrochloride Agonist 99.05% Unkown
HY-111793 NUCC-390 Agonist 98.40% Unkown
HY-RS02585 CGN Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CGN MGD MGI:1927237
Macaca mulatta CGN VGNC VGNC:70968
Felis catus CGN VGNC VGNC:80168
Bos taurus CGN VGNC VGNC:27258
Rattus norvegicus CGN RGD RGD:1311992
Canis familiaris CGN VGNC VGNC:39183
Others CGN NCBI