PTMA - prothymosin alpha Gene

Homo sapiens

Also known as TMSA

Gene ID: 5757 | Gene type: protein coding

About PTMA

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:231,708,525-231,713,551 (from NCBI)

This gene has 12 transcripts (splice variants) and 103 orthologues. Ubiquitous expression in bone marrow (RPKM 272.9), lymph node (RPKM 218.9) and 25 other tissues.

Summary

Enables DNA-binding transcription factor binding activity. Involved in negative regulation of apoptotic process. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PTMA Products(2)

mRNA	Protein	Name
NM_001099285.2	NP_001092755.1	prothymosin alpha isoform 1
NM_002823.5	NP_002814.3	prothymosin alpha isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	11897665	GOA
enables histone binding	IPI IPI: Inferred from physical interaction	29466338	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15607035	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16478804	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	8485135	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTMA Protein Structure

Prothymosin

0
100
111 a.a.

Protein Preferred Names

Protein Names

prothymosin alpha

gene sequence 28

PTMA Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PTMA	P06454	NUPR1	Homo sapiens	O60356	NMR	16478804
Intra	PTMA	P06454	NUPR1	Homo sapiens	O60356	Anti Bait CoIP	16478804
Intra	PTMA	P06454	NUPR1	Homo sapiens	O60356	Y2H	16478804
Intra	PTMA	P06454	NUPR1	Homo sapiens	O60356	Fluorescence Spectr	16478804
Intra	PTMA	P06454	NUPR1	Homo sapiens	O60356	CD	16478804
Intra	PTMA	P06454	TERF2IP	Homo sapiens	Q9NYB0	Pull Down	21044950
Intra	PTMA	P06454	TERF2IP	Homo sapiens	Q9NYB0	BiFC	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PTMA Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75992	PTMA Protein, Human (GST)	P06454-1 (S2-D111)	≥95%

Related Diseases

Diseases

Alias

Hepatitis B

Chronic Hepatitis B	Hepatitis B Infection
Serum Hepatitis	HBV
Hepatitis B Chronic	Hbv, Susceptibility To
Hepatitis B, Chronic	Chronic Hepatitis B Without Delta Agent
Chronic Hbv - [Hepatitis B Virus] Infection	Hepatitis B Nos
Chronic Type B Viral Hepatitis	Hep B Nos

Invasive Malignant Thymoma

Infiltrating Thymoma	Thymoma Malignant Invasive
Invasive Thymoma And Thymic Carcinoma

Thymoma

Primary Thymic Epithelial Neoplasm	Primary Thymic Epithelial Tumor
Thymus Neoplasms

Viral Hepatitis

Animal Viral Hepatitis	Hepatitis, Viral, Animal
Human Viral Hepatitis	Viral Hepatitis With Hepatic Coma

Hepatoblastoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11405	PTMA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PTMA	RGD	RGD:61829
Felis catus	PTMA	VGNC	VGNC:107609
Mus musculus	PTMA	MGD	MGI:97803
Others	PTMA	NCBI

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