SLAIN2 - SLAIN motif family member 2 Gene

Homo sapiens

Also known as KIAA1458

Gene ID: 57606 | Gene type: protein coding

About SLAIN2

Cytogenetic location: 4p11 Genomic coordinates (GRCh38): 4:48,341,529-48,426,201 (from NCBI)

This gene has 5 transcripts (splice variants), 199 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 22.9), esophagus (RPKM 14.0) and 25 other tissues.

Summary

Involved in cytoplasmic microtubule organization; microtubule nucleation; and positive regulation of microtubule polymerization. Located in centrosome and cytosol. Colocalizes with microtubule plus-end. [provided by Alliance of Genome Resources, Apr 2022]

SLAIN2 Products(1)

mRNA	Protein	Name
NM_020846.2	NP_065897.1	SLAIN motif-containing protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21646404	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cytoplasmic microtubule organization	IMP IMP: Inferred from mutant phenotype	21646404	GOA
involved in microtubule nucleation	IMP IMP: Inferred from mutant phenotype	21646404	GOA
involved in positive regulation of microtubule polymerization	IMP IMP: Inferred from mutant phenotype	21646404	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centrosome	IDA IDA: Inferred from direct assay	21399614	GOA
located in microtubule cytoskeleton	IDA IDA: Inferred from direct assay	21646404	GOA
colocalizes with microtubule plus-end	IDA IDA: Inferred from direct assay	21646404	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLAIN2 Protein Structure

SLAIN

0
100
200
300
400
500
581 a.a.

Protein Preferred Names

Protein Names

SLAIN motif-containing protein 2

Related Diseases

Diseases

Alias

Schizophrenia 3

SCZD3	Schizophrenia Susceptibility Locus, Chromosome 6-Related
Schizophrenia 3 With Or Without An Affective Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12978	SLAIN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SLAIN2	RGD	RGD:1311593
Felis catus	SLAIN2	VGNC	VGNC:65176
Mus musculus	SLAIN2	MGD	MGI:1923241
Bos taurus	SLAIN2	VGNC	VGNC:34652
Canis familiaris	SLAIN2	VGNC	VGNC:46205
Macaca mulatta	SLAIN2	VGNC	VGNC:107198

Name
Email *

	Sorry, but the email address you supplied was invalid.