CKAP5 - cytoskeleton associated protein 5 Gene

Homo sapiens

Also known as TOG; MSPS; TOGp; CHTOG; ch-TOG

Gene ID: 9793 | Gene type: protein coding

About CKAP5

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:46,743,048-46,846,280 (from NCBI)

This gene has 12 transcripts (splice variants) and 219 orthologues. Ubiquitous expression in testis (RPKM 29.0), brain (RPKM 23.7) and 25 other tissues.

Summary

This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also plays a role in translation of the myelin basic protein (MBP) mRNA by interacting with heterogeneous nuclear ribonucleoprotein (hnRNP) A2, which associates with MBP. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

CKAP5 Products(2)

mRNA	Protein	Name
NM_001008938.4	NP_001008938.1	cytoskeleton-associated protein 5 isoform a
NM_014756.4	NP_055571.2	cytoskeleton-associated protein 5 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables microtubule binding	IDA IDA: Inferred from direct assay	10770946	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11903063	GOA
enables ribonucleoprotein complex binding	IDA IDA: Inferred from direct assay	15703215	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within centrosome cycle	IMP IMP: Inferred from mutant phenotype	14718566	GOA
involved in centrosome cycle	IMP IMP: Inferred from mutant phenotype	14718566	GOA
involved in establishment or maintenance of microtubule cytoskeleton polarity	IMP IMP: Inferred from mutant phenotype	14718566	GOA
involved in positive regulation of microtubule nucleation	IDA IDA: Inferred from direct assay	26414402	GOA
involved in spindle organization	IMP IMP: Inferred from mutant phenotype	14718566	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centrosome	IDA IDA: Inferred from direct assay	14718566	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	15703215	GOA
located in kinetochore	IDA IDA: Inferred from direct assay	25596274	GOA
colocalizes with microtubule plus-end	IDA IDA: Inferred from direct assay	21646404	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	18468998	GOA
located in spindle pole	IDA IDA: Inferred from direct assay	21646404	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CKAP5 Protein Structure

CLASP_N

0
400
800
1200
1600
2032 a.a.

Protein Preferred Names

Protein Names

cytoskeleton-associated protein 5

colonic and hepatic tumor over-expressed gene protein

CKAP5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CKAP5	Q14008	TACC3	Homo sapiens	Q9Y6A5	Anti Bait CoIP	21297582
Intra	CKAP5	Q14008	TACC3	Homo sapiens	Q9Y6A5	IF	21297582
Intra	CKAP5	Q14008	TACC3	Homo sapiens	Q9Y6A5	Anti Tag CoIP	26496610
Intra	CKAP5	Q14008	TACC3	Homo sapiens	Q9Y6A5	Anti Tag CoIP	33961781
Intra	CKAP5	Q14008	TACC3	Homo sapiens	Q9Y6A5	TAP	20360068
Intra	CKAP5	Q14008	NCK1	Homo sapiens	P16333	Peptide Array	17474147
Intra	CKAP5	Q14008	SLAIN2	Homo sapiens	Q9P270	Anti Tag CoIP	33961781
Intra	CKAP5	Q14008	SLAIN2	Homo sapiens	Q9P270	Anti Tag CoIP	26496610
Intra	CKAP5	Q14008	TACC1	Homo sapiens	O75410	Pull Down	14603251
Intra	CKAP5	Q14008	TACC1	Homo sapiens	O75410	Anti Tag CoIP	26496610
Intra	CKAP5	Q14008	TACC1	Homo sapiens	O75410	Anti Tag CoIP	33961781
Intra	CKAP5	Q14008	TACC1	Homo sapiens	O75410-1	Anti Bait CoIP	14603251

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02735	CKAP5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CKAP5	MGD	MGI:1923036
Felis catus	CKAP5	VGNC	VGNC:60912
Bos taurus	CKAP5	VGNC	VGNC:27383
Macaca mulatta	CKAP5	VGNC	VGNC:71368
Canis familiaris	CKAP5	VGNC	VGNC:39289
Rattus norvegicus	CKAP5	RGD	RGD:1563596

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