BEND3 - BEN domain containing 3 Gene

Homo sapiens

Also known as KIAA1553

Gene ID: 57673 | Gene type: protein coding

About BEND3

Cytogenetic location: 6q21 Genomic coordinates (GRCh38): 6:107,065,182-107,115,515 (from NCBI)

This gene has 2 transcripts (splice variants) and 196 orthologues. Ubiquitous expression in stomach (RPKM 1.1), testis (RPKM 1.1) and 25 other tissues.

Summary

Enables rDNA binding activity. Involved in several processes, including histone modification; negative regulation of macromolecule metabolic process; and protein homooligomerization. Located in heterochromatin; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

BEND3 Products(2)

mRNA	Protein	Name
NM_001080450.3	NP_001073919.1	BEN domain-containing protein 3
NM_001367314.1	NP_001354243.1	BEN domain-containing protein 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21914818	GOA
enables rDNA binding	IDA IDA: Inferred from direct assay	26100909	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA methylation-dependent heterochromatin formation	IMP IMP: Inferred from mutant phenotype	26100909	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21914818	GOA
involved in positive regulation of ATP metabolic process	IDA IDA: Inferred from direct assay	28977671	GOA
involved in protein homooligomerization	IDA IDA: Inferred from direct assay	28977671	GOA
involved in rDNA heterochromatin formation	IMP IMP: Inferred from mutant phenotype	26100909	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in heterochromatin	IDA IDA: Inferred from direct assay	21914818	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	26100909	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BEND3 Protein Structure

BEN

0
200
400
600
828 a.a.

Protein Preferred Names

Protein Names

BEN domain-containing protein 3

BEND3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	BEND3	Q5T5X7	MORN4	Homo sapiens	Q8NDC4	Validated Y2H	32296183
Intra	BEND3	Q5T5X7	MORN4	Homo sapiens	Q8NDC4	Y2H Array	25416956
Intra	BEND3	Q5T5X7	MCRS1	Homo sapiens	Q96EZ8	Validated Y2H	32296183
Intra	BEND3	Q5T5X7	FAM161A	Homo sapiens	Q3B820	Y2H Array	25416956
Intra	BEND3	Q5T5X7	DPY30	Homo sapiens	Q9C005	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Heel Spur

Calcaneal Spur

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-169022	4-FPBUA		/	Unkown
HY-RS01469	BEND3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	BEND3	MGD	MGI:2677212
Canis familiaris	BEND3	VGNC	VGNC:38430
Rattus norvegicus	BEND3	RGD	RGD:1596570
Felis catus	BEND3	VGNC	VGNC:60101
Bos taurus	BEND3	VGNC	VGNC:26466
Macaca mulatta	BEND3	VGNC	VGNC:104312

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