POLD4 - DNA polymerase delta 4, accessory subunit Gene

Homo sapiens

Also known as p12; POLDS

Gene ID: 57804 | Gene type: protein coding

About POLD4

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:67,350,765-67,353,596 (from NCBI)

This gene has 12 transcripts (splice variants) and 165 orthologues. Ubiquitous expression in lymph node (RPKM 33.7), small intestine (RPKM 29.8) and 25 other tissues.

Summary

This gene encodes the smallest subunit of DNA Polymerase delta. DNA Polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein enhances the activity of DNA Polymerase delta and plays a role in fork repair and stabilization through interactions with the DNA helicase Bloom syndrome protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

POLD4 Products(2)

mRNA	Protein	Name
NM_001256870.2	NP_001243799.1	DNA polymerase delta subunit 4 isoform 2
NM_021173.5	NP_066996.3	DNA polymerase delta subunit 4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12403614	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA-templated DNA replication	IDA IDA: Inferred from direct assay	20334433	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of delta DNA polymerase complex	IPI IPI: Inferred from physical interaction	12403614	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POLD4 Protein Structure

DNA_pol_delta_4

0
100
107 a.a.

Protein Preferred Names

Protein Names

DNA polymerase delta subunit 4

DNA polymerase delta smallest subunit p12

POLD4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	POLD4	Q9HCU8	PCNA	Homo sapiens	P12004	ELISA	16510448
Intra	POLD4	Q9HCU8	POLD2	Homo sapiens	P49005	Pull Down	16510448
Intra	POLD4	Q9HCU8	POLD2	Homo sapiens	P49005	Pull Down	31449058
Intra	POLD4	Q9HCU8	POLD1	Homo sapiens	P28340	Y2H	16510448
Intra	POLD4	Q9HCU8	POLD1	Homo sapiens	P28340	Pull Down	31449058
Intra	POLD4	Q9HCU8	POLD1	Homo sapiens	P28340	Pull Down	16510448

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10822	POLD4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	POLD4	VGNC	VGNC:105828
Rattus norvegicus	POLD4	RGD	RGD:1308519
Macaca mulatta	POLD4	VGNC	VGNC:101382
Mus musculus	POLD4	MGD	MGI:1916995

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