2. Gene
  3. CTDSP1 - CTD small phosphatase 1 Gene

CTDSP1 - CTD small phosphatase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as NIF3; SCP1; NLIIF; NLI-IF

Gene ID: 58190 | Gene type: protein coding

About CTDSP1

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:218,396,351-218,405,941 (from NCBI)

This gene has 15 transcripts (splice variants), 256 orthologues and 5 paralogues. Ubiquitous expression in placenta (RPKM 26.9), ovary (RPKM 24.5) and 25 other tissues.

Summary

This gene encodes a member of the small C-terminal domain Phosphatase (SCP) family of nuclear phosphatases. These proteins play a role in transcriptional regulation through specific dephosphorylation of phosphoserine 5 within tandem heptapeptide repeats of the C-terminal domain of RNA polymerase II. The encoded protein plays a role in neuronal gene silencing in non-neuronal cells, and may also inhibit osteoblast differentiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

CTDSP1 Products(12)

mRNA Protein Name
NM_001206878.2 NP_001193807.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 3
NM_001400268.1 NP_001387197.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 2
NM_001400269.1 NP_001387198.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 4
NM_001400270.1 NP_001387199.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 5
NM_001400271.1 NP_001387200.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 6
NM_001400272.1 NP_001387201.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 7
NM_001400273.1 NP_001387202.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 8
NM_001400274.1 NP_001387203.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 9
NM_001400275.1 NP_001387204.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 10
NM_001400276.1 NP_001387205.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 11
NM_021198.3 NP_067021.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1
NM_182642.3 NP_872580.1 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity IDA
IDA: Inferred from direct assay
12721286 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12721286 GOA
Biological Process GO Annotation Evidence Reference Source
involved in protein dephosphorylation IDA
IDA: Inferred from direct assay
12721286 GOA
involved in regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12721286 GOA
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
12721286 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CTDSP1 Protein Structure

NIF

NIF: NLI interacting factor-like phosphatase (92 - 250)

  • 0
  • 100
  • 200
  • 261 a.a.
Protein Preferred Names Protein Names

carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03291 CTDSP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CTDSP1 VGNC VGNC:39693
Felis catus CTDSP1 VGNC VGNC:61247
Rattus norvegicus CTDSP1 RGD RGD:1305629
Mus musculus CTDSP1 MGD MGI:2654470
Macaca mulatta CTDSP1 VGNC VGNC:71448
Bos taurus CTDSP1 VGNC VGNC:27790