CTDSP1 - CTD small phosphatase 1 Gene

Homo sapiens

Also known as NIF3; SCP1; NLIIF; NLI-IF

Gene ID: 58190 | Gene type: protein coding

About CTDSP1

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:218,396,351-218,405,941 (from NCBI)

This gene has 15 transcripts (splice variants), 256 orthologues and 5 paralogues. Ubiquitous expression in placenta (RPKM 26.9), ovary (RPKM 24.5) and 25 other tissues.

Summary

This gene encodes a member of the small C-terminal domain Phosphatase (SCP) family of nuclear phosphatases. These proteins play a role in transcriptional regulation through specific dephosphorylation of phosphoserine 5 within tandem heptapeptide repeats of the C-terminal domain of RNA polymerase II. The encoded protein plays a role in neuronal gene silencing in non-neuronal cells, and may also inhibit osteoblast differentiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

CTDSP1 Products(12)

mRNA	Protein	Name
NM_001206878.2	NP_001193807.1	carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 3
NM_001400268.1	NP_001387197.1	carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 2
NM_001400269.1	NP_001387198.1	carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 4
NM_001400270.1	NP_001387199.1	carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 5
NM_001400271.1	NP_001387200.1	carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 6
NM_001400272.1	NP_001387201.1	carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 7
NM_001400273.1	NP_001387202.1	carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 8
NM_001400274.1	NP_001387203.1	carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 9
NM_001400275.1	NP_001387204.1	carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 10
NM_001400276.1	NP_001387205.1	carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 11
NM_021198.3	NP_067021.1	carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1
NM_182642.3	NP_872580.1	carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity	IDA IDA: Inferred from direct assay	12721286	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12721286	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein dephosphorylation	IDA IDA: Inferred from direct assay	12721286	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12721286	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	12721286	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CTDSP1 Protein Structure

NIF

0
100
200
261 a.a.

Protein Preferred Names

Protein Names

carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1

CTDSP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CTDSP1	Q9GZU7	WWOX	Homo sapiens	Q9NZC7-5	Validated Y2H	32296183
Intra	CTDSP1	Q9GZU7	SMAD1	Homo sapiens	Q15797	Anti Tag CoIP	16882717
Intra	CTDSP1	Q9GZU7	FANCL	Homo sapiens	Q9NW38	Validated Y2H	32296183
Cross	CTDSP1	Q9GZU7	Ctdsp1	Mus musculus	P58466	Anti Bait CoIP	14743429
Intra	CTDSP1	Q9GZU7	CDCA3	Homo sapiens	Q99618	Anti Tag CoIP	33961781
Intra	CTDSP1	Q9GZU7	CDCA3	Homo sapiens	Q99618	Anti Tag CoIP	27880917
Intra	CTDSP1	Q9GZU7	CDCA3	Homo sapiens	Q99618	Y2H Pooling	16189514
Intra	CTDSP1	Q9GZU7	CDCA3	Homo sapiens	Q99618	Anti Tag CoIP	28514442
Intra	CTDSP1	Q9GZU7	CDCA3	Homo sapiens	Q99618	Y2H Prey Pooling	25416956
Intra	CTDSP1	Q9GZU7	CDCA3	Homo sapiens	Q99618	Validated Y2H	25416956
Intra	CTDSP1	Q9GZU7	CDCA3	Homo sapiens	Q99618	Y2H Array	25416956
Intra	CTDSP1	Q9GZU7	CSTF2T	Homo sapiens	Q9H0L4	Validated Y2H	32296183
Intra	CTDSP1	Q9GZU7	MBP	Homo sapiens	P02686	Y2H Prey Pooling	25416956
Intra	CTDSP1	Q9GZU7	MBP	Homo sapiens	P02686	Y2H Array	25416956
Intra	CTDSP1	Q9GZU7	MBP	Homo sapiens	P02686	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03291	CTDSP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CTDSP1	VGNC	VGNC:39693
Felis catus	CTDSP1	VGNC	VGNC:61247
Rattus norvegicus	CTDSP1	RGD	RGD:1305629
Mus musculus	CTDSP1	MGD	MGI:2654470
Macaca mulatta	CTDSP1	VGNC	VGNC:71448
Bos taurus	CTDSP1	VGNC	VGNC:27790

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