ENOPH1 - enolase-phosphatase 1 Gene

Homo sapiens

Also known as E1; MASA; mtnC; MST145

Gene ID: 58478 | Gene type: protein coding

About ENOPH1

This gene has 3 transcripts (splice variants) and 226 orthologues. Ubiquitous expression in brain (RPKM 34.5), thyroid (RPKM 16.6) and 25 other tissues.

Summary

Enables acireductone synthase activity. Involved in L-methionine salvage from methylthioadenosine. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

ENOPH1 Products(2)

mRNA	Protein	Name
NM_001292017.2	NP_001278946.1	enolase-phosphatase E1 isoform 2
NM_021204.5	NP_067027.1	enolase-phosphatase E1 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables acireductone synthase activity	IDA IDA: Inferred from direct assay	15843022	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in L-methionine salvage from methylthioadenosine	IDA IDA: Inferred from direct assay	15843022	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ENOPH1 Protein Structure

HAD_2

0
100
200
261 a.a.

Protein Preferred Names

Protein Names

enolase-phosphatase E1

2,3-diketo-5-methylthio-1-phosphopentane phosphatase

ENOPH1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ENOPH1	Q9UHY7	RNF41	Homo sapiens	Q9H4P4	Y2H Prey Pooling	32296183
Intra	ENOPH1	Q9UHY7	RNF41	Homo sapiens	Q9H4P4	Y2H Array	32296183
Intra	ENOPH1	Q9UHY7	RNF41	Homo sapiens	Q9H4P4	Anti Tag CoIP	28514442
Intra	ENOPH1	Q9UHY7	RNF41	Homo sapiens	Q9H4P4	Anti Tag CoIP	33961781
Intra	ENOPH1	Q9UHY7	ZNF280A	Homo sapiens	P59817	Y2H Prey Pooling	32296183
Intra	ENOPH1	Q9UHY7	ZNF280A	Homo sapiens	P59817	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Chromosome 4q21 Deletion Syndrome

4q21 Microdeletion Syndrome	Monosomy 4q21
Del(4)(Q21)	Chromosome Deletion Syndrome 4q21

Malignant Hemangioma

Atrial Septal Defect 1

ASD1	Atrial Heart Septal Defect 1
Asd

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04382	ENOPH1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ENOPH1	MGD	MGI:1915120
Rattus norvegicus	ENOPH1	RGD	RGD:1309016
Felis catus	ENOPH1	VGNC	VGNC:107330
Canis familiaris	ENOPH1	VGNC	VGNC:40369
Bos taurus	ENOPH1	VGNC	VGNC:28500

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