RTN4IP1 - reticulon 4 interacting protein 1 Gene

Homo sapiens

Also known as NIMP; OPA10

Gene ID: 84816 | Gene type: protein coding

About RTN4IP1

Cytogenetic location: 6q21 Genomic coordinates (GRCh38): 6:106,570,771-106,630,491 (from NCBI)

This gene has 4 transcripts (splice variants), 270 orthologues, 17 paralogues and is associated with 4 phenotypes. Ubiquitous expression in skin (RPKM 10.5), placenta (RPKM 7.8) and 24 other tissues.

Summary

This gene encodes a mitochondrial protein that interacts with reticulon 4, which is a potent inhibitor of regeneration following spinal cord injury. This interaction may be important for reticulon-induced inhibition of neurite growth. Mutations in this gene can cause optic atrophy 10, with or without ataxia, cognitive disability, and seizures. There is a pseudogene for this gene on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

RTN4IP1 Products(2)

mRNA	Protein	Name
NM_001318746.1	NP_001305675.1	reticulon-4-interacting protein 1, mitochondrial isoform 2
NM_032730.5	NP_116119.2	reticulon-4-interacting protein 1, mitochondrial isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables NADPH dehydrogenase (quinone) activity	IDA IDA: Inferred from direct assay	37884807	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	29892012	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ubiquinone biosynthetic process	IDA IDA: Inferred from direct assay	37884807	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in mitochondrial matrix	IDA IDA: Inferred from direct assay	37884807	GOA
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	26593267	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RTN4IP1 Protein Structure

ADH_N

ADH_zinc_N_2

0
100
200
300
396 a.a.

Protein Preferred Names

Protein Names

reticulon-4-interacting protein 1, mitochondrial

NOGO-interacting mitochondrial protein

RTN4IP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RTN4IP1	Q8WWV3	RELA	Homo sapiens	Q96CP1	Validated Y2H	32296183
Intra	RTN4IP1	Q8WWV3	HDX	Homo sapiens	Q7Z353	Y2H Array	32296183
Intra	RTN4IP1	Q8WWV3	HDX	Homo sapiens	Q7Z353	Y2H Prey Pooling	32296183
Intra	RTN4IP1	Q8WWV3	CTAG1A	Homo sapiens	P78358	Y2H Prey Pooling	32296183
Intra	RTN4IP1	Q8WWV3	CTAG1A	Homo sapiens	P78358	Y2H Array	32296183
Intra	RTN4IP1	Q8WWV3	SCAF1	Homo sapiens	Q9H7N4	Validated Y2H	32296183
Intra	RTN4IP1	Q8WWV3	PPP1R8	Homo sapiens	Q12972-2	Y2H Prey Pooling	32296183
Intra	RTN4IP1	Q8WWV3	PPP1R8	Homo sapiens	Q12972-2	Y2H Array	32296183
Intra	RTN4IP1	Q8WWV3	SORBS1	Homo sapiens	Q9BX66-7	Y2H Prey Pooling	32296183
Intra	RTN4IP1	Q8WWV3	SORBS1	Homo sapiens	Q9BX66-7	Y2H Array	32296183
Intra	RTN4IP1	Q8WWV3	SORBS1	Homo sapiens	Q9BX66-7	Validated Y2H	32296183
Intra	RTN4IP1	Q8WWV3	MARCHF5	Homo sapiens	Q9NX47	Y2H Prey Pooling	32296183
Intra	RTN4IP1	Q8WWV3	MARCHF5	Homo sapiens	Q9NX47	Validated Y2H	32296183
Intra	RTN4IP1	Q8WWV3	MARCHF5	Homo sapiens	Q9NX47	Y2H Array	32296183
Intra	RTN4IP1	Q8WWV3	PYM1	Homo sapiens	Q9BRP8	Validated Y2H	32296183
Intra	RTN4IP1	Q8WWV3	PYM1	Homo sapiens	Q9BRP8	Y2H Array	32296183
Intra	RTN4IP1	Q8WWV3	PYM1	Homo sapiens	Q9BRP8	Y2H Prey Pooling	32296183
Intra	RTN4IP1	Q8WWV3	ARFGAP3	Homo sapiens	Q9NP61	Validated Y2H	32296183
Intra	RTN4IP1	Q8WWV3	ARFGAP3	Homo sapiens	Q9NP61	Y2H Array	32296183
Intra	RTN4IP1	Q8WWV3	ARFGAP3	Homo sapiens	Q9NP61	Y2H Prey Pooling	32296183
Intra	RTN4IP1	Q8WWV3	SMURF2	Homo sapiens	Q9HAU4	Validated Y2H	32296183
Intra	RTN4IP1	Q8WWV3	SMURF2	Homo sapiens	Q9HAU4	Y2H Array	32296183
Intra	RTN4IP1	Q8WWV3	SMURF2	Homo sapiens	Q9HAU4	Y2H Prey Pooling	32296183
Intra	RTN4IP1	Q8WWV3	ZYX	Homo sapiens	Q15942	Y2H Array	29892012
Intra	RTN4IP1	Q8WWV3	ZYX	Homo sapiens	Q15942	Y2H Array	31515488
Intra	RTN4IP1	Q8WWV3	ZYX	Homo sapiens	Q15942	Y2H Prey Pooling	32296183
Intra	RTN4IP1	Q8WWV3	ZYX	Homo sapiens	Q15942	Y2H Array	32296183
Intra	RTN4IP1	Q8WWV3	GGA2	Homo sapiens	Q9UJY4	Validated Y2H	32296183
Intra	RTN4IP1	Q8WWV3	GGA2	Homo sapiens	Q9UJY4	Y2H Array	32296183
Intra	RTN4IP1	Q8WWV3	GGA2	Homo sapiens	Q9UJY4	Y2H Prey Pooling	32296183
Intra	RTN4IP1	Q8WWV3	CENPK	Homo sapiens	Q9BS16	Y2H Prey Pooling	32296183
Intra	RTN4IP1	Q8WWV3	CENPK	Homo sapiens	Q9BS16	Y2H Array	32296183
Intra	RTN4IP1	Q8WWV3	CENPK	Homo sapiens	Q9BS16	Validated Y2H	32296183
Intra	RTN4IP1	Q8WWV3	WWTR1	Homo sapiens	Q9GZV5	Y2H Array	32296183
Intra	RTN4IP1	Q8WWV3	WWTR1	Homo sapiens	Q9GZV5	Validated Y2H	32296183
Intra	RTN4IP1	Q8WWV3	WWTR1	Homo sapiens	Q9GZV5	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Optic Atrophy 10 With Or Without Ataxia, Mental Retardation, And Seizures

OPA10	Optic Atrophy 10 With Or Without Ataxia, Intellectual Disability, And Seizures
Optic Atrophy 10	Atrophy, Optic, Type 10, With/Without Ataxia, Mental Retardation, And Seizures

Autosomal Recessive Isolated Optic Atrophy

Autosomal Recessive Non-Syndromic Optic Atrophy

Spinal Cord Injury

Spinal Cord Injuries

Optic Atrophy 9

OPA9	Atrophy, Optic, Type 9

Optic Atrophy 7 With Or Without Auditory Neuropathy

Optic Atrophy 7	OPA7
Autosomal Recessive Optic Atrophy, Opa7 Type	Optic Atrophy-7
Atrophy, Optic, Type 7, With/Without Auditory Neuropathy

Infantile Cerebellar-Retinal Degeneration

ICRD	Infantile Cerebellar Retinal Degeneration
Degeneration, Cerebellar-Retinal, Infantile

Optic Atrophy 5

OPA5	Atrophy, Optic, Type 5

Pontocerebellar Hypoplasia, Type 1e

Pontocerebellar Hypoplasia Type 1	PCH1E
Norman Disease	Pch1
Pontocerebellar Hypoplasia With Anterior Horn Cell Disease	Pontocerebellar Hypoplasia With Infantile Spinal Muscular Atrophy
Pontocerebellar Hypoplasia Type 1e	Pontocerebellar Hypoplasia 1e
Doid:0112322	Doid:0112330

Optic Atrophy 6

OPA6	Optic Atrophy, Congenital Or Early Infantile, Autosomal Recessive

3-Methylglutaconic Aciduria, Type Iii

Optic Atrophy	3-Methylglutaconic Aciduria Type 3
Costeff Syndrome	Mga3
Costeff Optic Atrophy Syndrome	Optic Atrophy Plus Syndrome
Infantile Optic Atrophy With Chorea And Spastic Paraplegia	3-Methylglutaconic Aciduria Type Iii
Autosomal Recessive Optic Atrophy Plus Syndrome	Autosomal Recessive Optic Atrophy Type 3
Opa3 Defect	MGCA3
Mga, Type Iii	Iraqi Jewish Optic Atrophy Plus
Mga Type Iii	Optic Atrophy, Infantile, With Chorea And Spastic Paraplegia
Iraqi-Jewish 'Optic Atrophy Plus'	Optic Atrophy 3, Autosomal Recessive
Opa3, Autosomal Recessive	Opa3-Related 3-Methylglutaconic Aciduria
Iraqi-Jewish Optic Atrophy Plus	Atrophy Of Optic Disc
3-Alpha Methylglutaconic Aciduria Type Iii	Optic Atrophy 3
Optic Atrophy Infantile With Chorea And Spastic Paraplegia	Autosomal Recessive Opa3
Autosomal Recessive Optic Atrophy 3	3-Methylglutaconic Aciduria 3
3-Alpha-Methylglutaconic Aciduria Type 3	Optic Atrophy 3 Autosomal Recessive
Atrophy, Optic	Atrophy, Optic, Plus Syndrome
Optic Nerve Atrophy	Primary Optic Atrophy
Oa - [Optic Atrophy]	Second Cranial Nerve Atrophy
Second Cranium Nerve Atrophy

Cerebellar Ataxia, Deafness, And Narcolepsy, Autosomal Dominant

Autosomal Dominant Cerebellar Ataxia, Deafness And Narcolepsy	ADCADN
Autosomal Dominant Cerebellar Ataxia, Deafness, And Narcolepsy	Adca-Dn Syndrome
Autosomal Dominant Cerebellar Ataxia-Deafness-Narcolepsy Syndrome	Adca-Dn
Autosomal Dominant Cerebellar Ataxia-Hearing Loss-Narcolepsy Syndrome	Ataxia, Cerebellar, Deafness, And Narcolepsy, Autosomal Dominant

Leber Hereditary Optic Neuropathy, Modifier Of

Leber Optic Atrophy	Leber Hereditary Optic Neuropathy
LHON	Leber'S Hereditary Optic Neuropathy
Leber Optic Atrophy, Susceptibility To	Leber'S Optic Atrophy
LOAM	Loas
Leber'S Disease	Leber'S Optic Neuropathy
Optic Atrophy, Hereditary, Leber	Lhon, Modifier Of
Optic Atrophy, Leber Type	Hereditary Optic Neuroretinopathy
Leber Hereditary Optic Atrophy	Loa
Optic Atrophy Leber Type	Leber Hereditary Optic Neuropathy, Modifier
Leber Hereditary Optic Neuropathy Susceptibility	Modifier Of Leber Hereditary Optic Neuropathy
Lebers Hereditary Optic Neuropathy	Leber Congenital Amaurosis

Mitochondrial Complex I Deficiency, Nuclear Type 1

Mitochondrial Complex I Deficiency	Nadh:Q(1) Oxidoreductase Deficiency
MC1DN1	Nadh-Coenzyme Q Reductase Deficiency
Isolated Mitochondrial Respiratory Chain Complex I Deficiency	Isolated Nadh-Coenzyme Q Reductase Deficiency
Isolated Nadh-Coq Reductase Deficiency	Isolated Nadh-Ubiquinone Reductase Deficiency
Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of	Nuclear Type Mitochondrial Complex I Deficiency 1
Isolated Complex I Deficiency	Complex 1 Mitochondrial Respiratory Chain Deficiency
Nadh Coenzyme Q Reductase Deficiency	Complex I Mitochondrial Respiratory Chain Deficiency
Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I	Nadh:Ubiquinone Oxidoreductase Deficiency
Complex I, Mitochondrial Respiratory Chain, Deficiency Of

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12333	RTN4IP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RTN4IP1	VGNC	VGNC:77049
Canis familiaris	RTN4IP1	VGNC	VGNC:45796
Mus musculus	RTN4IP1	MGD	MGI:2178759
Bos taurus	RTN4IP1	VGNC	VGNC:34205
Rattus norvegicus	RTN4IP1	RGD	RGD:1563384
Felis catus	RTN4IP1	VGNC	VGNC:64812

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