RAB5B - RAB5B, member RAS oncogene family Gene

Homo sapiens

Gene ID: 5869 | Gene type: protein coding

About RAB5B

Cytogenetic location: 12q13.2 Genomic coordinates (GRCh38): 12:55,973,949-55,996,683 (from NCBI)

This gene has 11 transcripts (splice variants), 135 orthologues and 68 paralogues. Ubiquitous expression in brain (RPKM 35.5), esophagus (RPKM 35.2) and 25 other tissues.

Summary

Enables GDP binding activity; GTP-dependent protein binding activity; and GTPase activity. Involved in antigen processing and presentation and plasma membrane to endosome transport. Located in endosome and extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

RAB5B Products(5)

mRNA	Protein	Name
NM_001252036.2	NP_001238965.1	ras-related protein Rab-5B isoform 1
NM_001252037.2	NP_001238966.1	ras-related protein Rab-5B isoform 2
NM_001414457.1	NP_001401386.1	ras-related protein Rab-5B isoform 1
NM_001414458.1	NP_001401387.1	ras-related protein Rab-5B isoform 3
NM_002868.4	NP_002859.1	ras-related protein Rab-5B isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GDP binding	IDA IDA: Inferred from direct assay	20937701	GOA
enables GTP-dependent protein binding	IDA IDA: Inferred from direct assay	10491193	GOA
enables GTPase activity	IDA IDA: Inferred from direct assay	17562788	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10491193	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in antigen processing and presentation	IMP IMP: Inferred from mutant phenotype	19717423	GOA
involved in plasma membrane to endosome transport	IMP IMP: Inferred from mutant phenotype	17562788	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endosome	IDA IDA: Inferred from direct assay	10491193	GOA
located in extracellular exosome	IDA IDA: Inferred from direct assay	15326289	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB5B Protein Structure

Ras

0
100
200
215 a.a.

Protein Preferred Names

Protein Names

ras-related protein Rab-5B

RAB5B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RAB5B	P61020	EEA1	Homo sapiens	Q15075	Y2H	10491193
Intra	RAB5B	P61020	EEA1	Homo sapiens	Q15075	IF	10491193
Intra	RAB5B	P61020	LRRK2	Homo sapiens	Q5S007	GTPase Assay	25605758
Intra	RAB5B	P61020	LRRK2	Homo sapiens	Q5S007	Y2H	18445495
Intra	RAB5B	P61020	LRRK2	Homo sapiens	Q5S007	Protein Kinase Assay	25605758
Intra	RAB5B	P61020	LRRK2	Homo sapiens	Q5S007	Anti Bait CoIP	18445495

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11572	RAB5B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RAB5B	MGD	MGI:105938
Bos taurus	RAB5B	VGNC	VGNC:33659
Macaca mulatta	RAB5B	VGNC	VGNC:81546
Rattus norvegicus	RAB5B	RGD	RGD:1306489
Canis familiaris	RAB5B	VGNC	VGNC:45292
Felis catus	RAB5B	VGNC	VGNC:97593

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