RAB13 - RAB13, member RAS oncogene family Gene

Homo sapiens

Also known as GIG4

Gene ID: 5872 | Gene type: protein coding

About RAB13

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:153,981,650-153,990,708 (from NCBI)

This gene has 5 transcripts (splice variants), 169 orthologues and 68 paralogues. Ubiquitous expression in urinary bladder (RPKM 34.2), prostate (RPKM 33.4) and 25 other tissues.

Summary

This gene is a member of the Rab family of small G proteins and plays a role in regulating membrane trafficking between trans-Golgi network (TGN) and recycling endosomes (RE). The encoded protein is involved in the assembly of tight junctions, which are components of the apical junctional complex (AJC) of epithelial cells. The AJC plays a role in forming a barrier between luminal contents and the underlying tissue. Additional functions associated with the protein include endocytic recycling of occludin, regulation of epithelial cell scattering, neuronal regeneration and regulation of neurite outgrowth. Alternately spliced transcript variants have been observed for this gene. A pseudogene associated with this gene is located on chromosome 12. [provided by RefSeq, Jan 2013]

RAB13 Products(2)

mRNA	Protein	Name
NM_001272038.2	NP_001258967.1	ras-related protein Rab-13 isoform 2
NM_002870.5	NP_002861.1	ras-related protein Rab-13 isoform 1

RAB13 Protein Structure

Ras

0
100
203 a.a.

Protein Preferred Names

Protein Names

ras-related protein Rab-13

RAS-associated protein RAB13

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11522	RAB13 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RAB13	RGD	RGD:620880
Canis familiaris	RAB13	VGNC	VGNC:45253
Bos taurus	RAB13	VGNC	VGNC:33621
Mus musculus	RAB13	MGD	MGI:1927232
Macaca mulatta	RAB13	VGNC	VGNC:106479

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