RAB13 - RAB13, member RAS oncogene family Gene

Homo sapiens

Also known as GIG4

Gene ID: 5872 | Gene type: protein coding

About RAB13

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:153,981,650-153,990,708 (from NCBI)

This gene has 5 transcripts (splice variants), 169 orthologues and 68 paralogues. Ubiquitous expression in urinary bladder (RPKM 34.2), prostate (RPKM 33.4) and 25 other tissues.

Summary

This gene is a member of the Rab family of small G proteins and plays a role in regulating membrane trafficking between trans-Golgi network (TGN) and recycling endosomes (RE). The encoded protein is involved in the assembly of tight junctions, which are components of the apical junctional complex (AJC) of epithelial cells. The AJC plays a role in forming a barrier between luminal contents and the underlying tissue. Additional functions associated with the protein include endocytic recycling of occludin, regulation of epithelial cell scattering, neuronal regeneration and regulation of neurite outgrowth. Alternately spliced transcript variants have been observed for this gene. A pseudogene associated with this gene is located on chromosome 12. [provided by RefSeq, Jan 2013]

RAB13 Products(2)

mRNA	Protein	Name
NM_001272038.2	NP_001258967.1	ras-related protein Rab-13 isoform 2
NM_002870.5	NP_002861.1	ras-related protein Rab-13 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTP binding	IDA IDA: Inferred from direct assay	20937701	GOA
enables GTPase activity	IDA IDA: Inferred from direct assay	8294494	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9712853	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Golgi to plasma membrane transport	IDA IDA: Inferred from direct assay	35343654	GOA
involved in bicellular tight junction assembly	IMP IMP: Inferred from mutant phenotype	15096524	GOA
involved in endocytic recycling	IMP IMP: Inferred from mutant phenotype	15528189	GOA
involved in endosomal transport	IMP IMP: Inferred from mutant phenotype	18779367	GOA
involved in neuron projection development	IMP IMP: Inferred from mutant phenotype	20008558	GOA
involved in protein kinase A signaling	IMP IMP: Inferred from mutant phenotype	15096524	GOA
involved in protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	15096524	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
NOT located in Golgi apparatus	IDA IDA: Inferred from direct assay	18779367	GOA
located in bicellular tight junction	IDA IDA: Inferred from direct assay	8294494	GOA
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	8294494	GOA
located in endocytic vesicle	IDA IDA: Inferred from direct assay	15528189	GOA
located in neuron projection	IDA IDA: Inferred from direct assay	20008558	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	15528189	GOA
located in recycling endosome	IDA IDA: Inferred from direct assay	18779367	GOA
located in trans-Golgi network	IDA IDA: Inferred from direct assay	18779367	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB13 Protein Structure

Ras

0
100
203 a.a.

Protein Preferred Names

Protein Names

ras-related protein Rab-13

RAS-associated protein RAB13

RAB13 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	RAB13	P51153	Micall2	Mus musculus	Q3TN34	Y2H	16525024
Cross	RAB13	P51153	Micall2	Mus musculus	Q3TN34	Anti Tag CoIP	18332111
Cross	RAB13	P51153	Micall2	Mus musculus	Q3TN34	Confocal	16525024
Intra	RAB13	P51153	PDE6D	Homo sapiens	O43924	Pull Down	9712853
Cross	RAB13	P51153	Leprotl1	Rattus norvegicus	Q6PDU4	Pull Down	23772379
Cross	RAB13	P51153	Leprotl1	Rattus norvegicus	Q6PDU4	Anti Tag CoIP	23772379

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11522	RAB13 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RAB13	RGD	RGD:620880
Canis familiaris	RAB13	VGNC	VGNC:45253
Bos taurus	RAB13	VGNC	VGNC:33621
Mus musculus	RAB13	MGD	MGI:1927232
Macaca mulatta	RAB13	VGNC	VGNC:106479

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