Pmaip1 - phorbol-12-myristate-13-acetate-induced protein 1 Gene

Mus musculus

Also known as Noxa

Gene ID: 58801 | Gene type: protein coding

About Pmaip1

Summary

Involved in several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic signaling pathway; and negative regulation of mitochondrial membrane potential. Acts upstream of or within several processes, including intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; and response to X-ray. Located in mitochondrion. Is expressed in several structures, including brain; immune system; limb; liver; and reproductive system. Orthologous to human PMAIP1 (phorbol-12-myristate-13-acetate-induced protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Pmaip1 Products(1)

mRNA	Protein	Name
NM_021451.2	NP_067426.1	phorbol-12-myristate-13-acetate-induced protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15694340	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within DNA damage response	IMP IMP: Inferred from mutant phenotype	12952892	MGI
involved in T cell homeostasis	IMP IMP: Inferred from mutant phenotype	18411339	MGI
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	14699081	MGI
acts upstream of fibroblast apoptotic process	IMP IMP: Inferred from mutant phenotype	14500851	MGI
involved in intrinsic apoptotic signaling pathway by p53 class mediator	IMP IMP: Inferred from mutant phenotype	14500851	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage	IMP IMP: Inferred from mutant phenotype	12952892	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IDA IDA: Inferred from direct assay	10807576	MGI
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	16407291	MGI
acts upstream of or within negative regulation of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	12952892	MGI
involved in negative regulation of mitochondrial membrane potential	IDA IDA: Inferred from direct assay	14699081	MGI
involved in positive regulation of DNA damage response, signal transduction by p53 class mediator	IMP IMP: Inferred from mutant phenotype	14500851	MGI
acts upstream of or within positive regulation of establishment of protein localization to mitochondrion	IMP IMP: Inferred from mutant phenotype	12952892	MGI
acts upstream of or within positive regulation of fibroblast apoptotic process	IMP IMP: Inferred from mutant phenotype	14500851	MGI
acts upstream of or within positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	15703398	MGI
involved in release of cytochrome c from mitochondria	IDA IDA: Inferred from direct assay	14699081	MGI
acts upstream of or within release of cytochrome c from mitochondria	IMP IMP: Inferred from mutant phenotype	12952892	MGI
acts upstream of or within response to UV	IMP IMP: Inferred from mutant phenotype	12952892	MGI
acts upstream of or within response to X-ray	IMP IMP: Inferred from mutant phenotype	12952892	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrion	IDA IDA: Inferred from direct assay	10807576	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

phorbol-12-myristate-13-acetate-induced protein 1

protein Noxa

Pmaip1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Pmaip1	Q9JM54	MCL1	Homo sapiens	Q07820	FPS	16697956
Intra	Pmaip1	Q9JM54	Mcl1	Mus musculus	P97287	ITC	17389404
Intra	Pmaip1	Q9JM54	Mcl1	Mus musculus	P97287	Anti Bait CoIP	20627101
Intra	Pmaip1	Q9JM54	Mcl1	Mus musculus	P97287	Anti Tag CoIP	20627101

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10758	PMAIP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pmaip1	NCBI	NCBI:5366

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