2. Gene
  3. Mcl1 - myeloid cell leukemia sequence 1 Gene

Mcl1 - myeloid cell leukemia sequence 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Mcl-1

Gene ID: 17210 | Gene type: protein coding

About Mcl1

Chromosome 3: 95,566,099-95,570,487 forward strand.GRCm39:CM000996.3

This gene has 2 transcripts (splice variants), 237 orthologues, 10 paralogues and is associated with 32 phenotypes. Ubiquitous expression in colon adult (RPKM 63.8), adrenal adult (RPKM 45.) and 28 other tissues.

Summary

Enables BH3 domain binding activity. Involved in extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of apoptotic process; and positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway. Acts upstream of or within apoptotic mitochondrial changes and intrinsic apoptotic signaling pathway in response to DNA damage. Located in several cellular components, including cytosol; mitochondrial matrix; and nucleus. Is expressed in several structures, including alimentary system; blastocyst; brain; genitourinary system; and hemolymphoid system gland. Orthologous to human MCL1 (MCL1 Apoptosis regulator, BCL2 family member). [provided by Alliance of Genome Resources, Apr 2022]

Mcl1 Products(1)

mRNA Protein Name
NM_008562.3 NP_032588.1 induced myeloid leukemia cell differentiation protein Mcl-1 homolog
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables BH3 domain binding IPI
IPI: Inferred from physical interaction
15901672 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15694340 MGI
Biological Process GO Annotation Evidence Reference Source
involved in extrinsic apoptotic signaling pathway in absence of ligand IMP
IMP: Inferred from mutant phenotype
16543145 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage IDA
IDA: Inferred from direct assay
15901672 MGI
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
17289999 MGI
involved in positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
23858059 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
20467439 MGI
located in cytosol IDA
IDA: Inferred from direct assay
16543145 MGI
located in membrane IDA
IDA: Inferred from direct assay
16543145 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
23858059 MGI
located in nucleus IDA
IDA: Inferred from direct assay
20467439 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mcl1 Protein Structure

Bcl-2_like

Bcl-2_like: cd06845 (155 - 298)

  • 0
  • 100
  • 200
  • 300
  • 331 a.a.
Protein Preferred Names Protein Names

induced myeloid leukemia cell differentiation protein Mcl-1 homolog

bcl-2-related protein EAT/mcl1

Mcl1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Cross
Mcl1 P97287 BAX Homo sapiens Q07812
Anti Tag CoIP
17289999
Cross
Mcl1 P97287 BAK1 Homo sapiens Q16611
Pull Down
15901672
Cross
Mcl1 P97287 BAK1 Homo sapiens Q16611
Anti Tag CoIP
15901672
Cross
Mcl1 P97287 BBC3 Homo sapiens Q9BXH1
SPR
15694340
Intra
Mcl1 P97287 Bcl2l11 Mus musculus O54918
Anti Bait CoIP
16543145
Intra
Mcl1 P97287 Bcl2l11 Mus musculus O54918
ITC
18589438
Intra
Mcl1 P97287 Bcl2l11 Mus musculus O54918
Anti Bait CoIP
20921992
Cross
Mcl1 P97287 BCL2L11 Homo sapiens O43521
Anti Bait CoIP
15694340
Cross
Mcl1 P97287 BCL2L11 Homo sapiens O43521
Anti Tag CoIP
15694340
Intra
Mcl1 P97287 Pmaip1 Mus musculus Q9JM54
NMR
17389404
Intra
Mcl1 P97287 Pmaip1 Mus musculus Q9JM54
NMR
18589438
Intra
Mcl1 P97287 Pmaip1 Mus musculus Q9JM54
Anti Tag CoIP
15694340
Intra
Mcl1 P97287 Pmaip1 Mus musculus Q9JM54
Phage Display
18589438
Intra
Mcl1 P97287 Pmaip1 Mus musculus Q9JM54
ITC
18589438
Intra
Mcl1 P97287 Pmaip1 Mus musculus Q9JM54
SPR
18589438
Intra
Mcl1 P97287 Bbc3 Mus musculus Q99ML1
ITC
18589438
Intra
Mcl1 P97287 Bbc3 Mus musculus Q99ML1
NMR
18589438
Intra
Mcl1 P97287 Bak1 Mus musculus O08734
NMR
18589438
Intra
Mcl1 P97287 Bak1 Mus musculus O08734
ITC
18589438
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase
Bioactive Molecules (17)
Cat. No. Product Name Effect
Purity Phase
HY-112041 Unesbulin 99.45% Phase 3
HY-101533 AZD-5991 Inhibitor 99.79% Phase 2
HY-112218 MIK665 Inhibitor 99.11% Phase 2
HY-15464A (R)-(-)-Gossypol acetic acid 98.93% Phase 2
HY-15464 (R)-(-)-Gossypol 98.82% Phase 2
HY-138697 S65487 99.91% Phase 2
HY-138697B S65487 hydrochloride 99.67% Phase 2
HY-138697A S65487 sulfate 98.08% Phase 2
HY-13559 Atiprimod / Phase 2
HY-101565 Tapotoclax Inhibitor 99.53% Phase 1
HY-12422 Voruciclib Inhibitor 99.77% Phase 1
HY-149672 ABBV-467 Inhibitor 99.78% Phase 1
HY-109184 Murizatoclax Inhibitor 98.85% Phase 1
HY-12422A Voruciclib hydrochloride Inhibitor 99.23% Phase 1
HY-101533B AZD-5991 (S-enantiomer) Inhibitor 99.83% Phase 1
HY-139453A LP-284 / Phase 1
HY-19471 (rac)-ZK-304709 / Phase 1
Pre-clinical Phase
Bioactive Molecules (121)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100741 S63845 Inhibitor 99.94% Unkown
HY-114855 BT2 Inhibitor 99.81% Unkown
HY-N0662 Amentoflavone 99.81% Unkown
HY-N0087 Gambogic Acid 98.79% Unkown
HY-12468 A-1210477 99.86% Unkown
HY-123954 BTX-A51 98.58% Unkown
HY-18628 UMI-77 Inhibitor 99.66% Unkown
HY-14985 BAY 61-3606 dihydrochloride 99.91% Unkown
HY-125877 PROTAC Mcl1 degrader-1 Inhibitor 98.13% Unkown
HY-125876 PROTAC Bcl2 degrader-1 Inhibitor 99.80% Unkown
HY-118341 Clitocine 95.88% Unkown
HY-N0763 Angelicin 99.98% Unkown
HY-129478 TC11 99.55% Unkown
HY-W008296 NH2-C6-NH-Boc 99.61% Unkown
HY-122627 CLZ-8 99.85% Unkown
HY-12020 TW-37 Inhibitor 99.27% Unkown
HY-117203A CDK12-IN-E9 Inhibitor 99.97% Unkown
HY-149007 STAT3-IN-11 98.30% Unkown
HY-N0831 Jaceosidin 99.51% Unkown
HY-15191 Sabutoclax Inhibitor 99.80% Unkown
HY-112859 VU0661013 Inhibitor 98.45% Unkown
HY-15613 Maritoclax Inhibitor 99.97% Unkown
HY-123955 Casein Kinase inhibitor A86 99.26% Unkown
HY-N8146 Bruceantinol Inhibitor 98.89% Unkown
HY-100741A (S,R)-S63845 Control 98.54% Unkown
HY-101778 ML311 Inhibitor 98.98% Unkown
HY-129681 MCL-1/BCL-2-IN-1 Inhibitor 99.86% Unkown
HY-76474A BAY 61-3606 hydrochloride 98.98% Unkown
HY-12527 Pyridoclax Inhibitor 99.95% Unkown
HY-160438B PBX-7011 TFA Inhibitor 98.60% Unkown
HY-16695 MIM1 Inhibitor ≥98.0% Unkown
HY-132307 Mcl-1 inhibitor 6 98.40% Unkown
HY-100741C (R,R)-S63845 Control 99.32% Unkown
HY-112591 NSC260594 96.00% Unkown
HY-119271 CMLD010509 99.11% Unkown
HY-129700 MCL-1/BCL-2-IN-2 Inhibitor 99.12% Unkown
HY-120113 SC-2001 / Unkown
HY-P2343 BH3 hydrochloride Activator 98.02% Unkown
HY-162858 BRD-810 Inducer 98.00% Unkown
HY-12826 IMB-XH1 Inhibitor ≥98.0% Unkown
HY-13408 (+)-Apogossypol Inhibitor / Unkown
HY-15191B (S)-Sabutoclax Inhibitor 98.03% Unkown
HY-164460 AZD1897 Inhibitor 99.69% Unkown
HY-16669 Mcl1-IN-1 Inhibitor 98.40% Unkown
HY-76474 BAY 61-3606 98.21% Unkown
HY-112218A (R)-MIK665 Inhibitor / Unkown
HY-125908 A-1210477-piperazinyl / Unkown
HY-128360 dMCL1-2 Inhibitor / Unkown
HY-128607 Mcl1-IN-9 Inhibitor / Unkown
HY-19551 Apogossypolone / Unkown
HY-100762 Mcl1-IN-11 Inhibitor / Unkown
HY-100763 Mcl1-IN-12 Inhibitor / Unkown
HY-101533A AZD-5991 Racemate Inhibitor / Unkown
HY-111537 rel-AZ5576 Inhibitor / Unkown
HY-130261 Mcl-1 antagonist 1 Antagonist / Unkown
HY-133015 Mcl-1 inhibitor 3 Inhibitor / Unkown
HY-145825 Mcl-1 inhibitor 7 Inhibitor / Unkown
HY-145825A (E)-Mcl-1 inhibitor 7 Inhibitor / Unkown
HY-146097 RMS5 / Unkown
HY-111467 Mcl1-IN-4 Inhibitor / Unkown
HY-111468 Mcl1-IN-3 Inhibitor / Unkown
HY-115928 M24 Inhibitor / Unkown
HY-122721 Mcl1-IN-5 Inhibitor / Unkown
HY-123034 CDKI-83 / Unkown
HY-123564 Mcl1-IN-7 Inhibitor / Unkown
HY-129701 MCL-1/BCL-2-IN-3 Inhibitor 99.22% Unkown
HY-129702 MCL-1/BCL-2-IN-4 Inhibitor / Unkown
HY-144428 Bcl-2/Mcl-1-IN-2 Inhibitor / Unkown
HY-144430 Bcl-2/Mcl-1-IN-1 Inhibitor / Unkown
HY-144431 Bcl-2/Mcl-1-IN-3 Inhibitor / Unkown
HY-145826 Mcl-1 inhibitor 8 Inhibitor / Unkown
HY-148203 Mcl-1 inhibitor 9 Inhibitor / Unkown
HY-148899 Mcl-1 inhibitor 10 Inhibitor / Unkown
HY-149495 CP-07 Degrader / Unkown
HY-150507 JNJ-4355 Inhibitor / Unkown
HY-15163A Zotiraciclib hydrochloride Inhibitor / Unkown
HY-153423 Mcl-1 inhibitor 12 Inhibitor / Unkown
HY-153423A Mcl-1 inhibitor 13 Inhibitor / Unkown
HY-154961 Mcl-1 inhibitor 14 / Unkown
HY-154962 Mcl-1 inhibitor 15 Inhibitor / Unkown
HY-155012 Mcl-1 inhibitor 16 Inhibitor / Unkown
HY-155153 CDK9-IN-24 / Unkown
HY-155245 A09-003 Inhibitor / Unkown
HY-155472 Mcl-1 inhibitor 17 Inhibitor ≥98.0% Unkown
HY-159513 Bcl-2/Mcl-1-IN-4 Inhibitor / Unkown
HY-159588 Mcl-1 inhibitor 20 Inhibitor / Unkown
HY-161274 Bfl-1-IN-1 Inhibitor / Unkown
HY-161732 GQN-B37-E Inhibitor / Unkown
HY-161733 GQN-B37-Me Inhibitor / Unkown
HY-162619 CDK9-IN-33 / Unkown
HY-162780 Mcl-1 inhibitor 19 Inhibitor / Unkown
HY-163293 Mcl-1 inhibitor 18 Inhibitor / Unkown
HY-163681 Zamzetoclax Inhibitor / Unkown
HY-164452 A-1155905 / Unkown
HY-164453 A-1248767 / Unkown
HY-169797 STAT3-IN-38 / Unkown
HY-170368 3′-Me Meayamycin D Modulator / Unkown
HY-170762 Mcl-1 inhibitor 21 Inducer / Unkown
HY-170762A (+)-Mcl-1 inhibitor 21 Inducer / Unkown
HY-170762B (-)-Mcl-1 inhibitor 21 Inducer / Unkown
HY-170763 Mcl-1 inhibitor 22 Inducer / Unkown
HY-170763A (+)-Mcl-1 inhibitor 22 Inducer / Unkown
HY-170763B (-)-Mcl-1 inhibitor 22 / Unkown
HY-18628S UMI-77-d4 Inhibitor / Unkown
HY-N0831R Jaceosidin (Standard) / Unkown
HY-N3913 Furowanin A Inhibitor / Unkown
HY-P4095 NoxaBH3 / Unkown
HY-RS08230 MCL1 Human Pre-designed siRNA Set A / Unkown
HY-RS08231 Mcl1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08232 Mcl1 Rat Pre-designed siRNA Set A / Unkown
HY-W689801 A-1208746 / Unkown
HY-115529 (-)BI97D6 Inducer / Unkown
HY-116532 YCW-E11 Inhibitor / Unkown
HY-119009 TM-233 Inhibitor / Unkown
HY-119271A (-)-CMLD010509 / Unkown
HY-121638B (E/Z)-CU-3 / Unkown
HY-158783 SACLAC / Unkown
HY-164466 CAD204520 Inhibitor / Unkown
HY-164468 Ch282-5 Inhibitor / Unkown
HY-167881 MLS-0053105 Inhibitor / Unkown
HY-W286906 Mcl1-IN-15 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mcl1 NCBI NCBI:4170