2. Gene
  3. RAD51B - RAD51 paralog B Gene

RAD51B - RAD51 paralog B Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as REC2; R51H2; RAD51L1

Gene ID: 5890 | Gene type: protein coding

About RAD51B

Cytogenetic location: 14q24.1 Genomic coordinates (GRCh38): 14:67,819,779-68,683,096 (from NCBI)

This gene has 24 transcripts (splice variants), 151 orthologues, 6 paralogues and is associated with 77 phenotypes. Low expression observed in reference dataset.

Summary

The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the Other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell Apoptosis, which suggested a role of this protein in sensing DNA damage. Rearrangements between this locus and high mobility group AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata. [provided by RefSeq, Mar 2016]

RAD51B Products(12)

mRNA Protein Name
NM_001321809.2 NP_001308738.1 DNA repair protein RAD51 homolog 2 isoform 4
NM_001321810.2 NP_001308739.1 DNA repair protein RAD51 homolog 2 isoform 4
NM_001321812.1 NP_001308741.1 DNA repair protein RAD51 homolog 2 isoform 5
NM_001321814.2 NP_001308743.1 DNA repair protein RAD51 homolog 2 isoform 5
NM_001321815.1 NP_001308744.1 DNA repair protein RAD51 homolog 2 isoform 6
NM_001321817.2 NP_001308746.1 DNA repair protein RAD51 homolog 2 isoform 10
NM_001321818.2 NP_001308747.1 DNA repair protein RAD51 homolog 2 isoform 7
NM_001321819.1 NP_001308748.1 DNA repair protein RAD51 homolog 2 isoform 8
NM_001321821.2 NP_001308750.1 DNA repair protein RAD51 homolog 2 isoform 9
NM_002877.6 NP_002868.1 DNA repair protein RAD51 homolog 2 isoform 1
NM_133509.5 NP_598193.2 DNA repair protein RAD51 homolog 2 isoform 3
NM_133510.4 NP_598194.1 DNA repair protein RAD51 homolog 2 isoform 2

RAD51B Protein Structure

Rad51

Rad51: Rad51 (82 - 342)

  • 0
  • 100
  • 200
  • 300
  • 384 a.a.
Protein Preferred Names Protein Names

DNA repair protein RAD51 homolog 2

RAD51 homolog B

RAD51B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
RAD51B O15315 FAM9B Homo sapiens Q8IZU0
Validated Y2H
25416956
Intra
RAD51B O15315 RAD51D Homo sapiens O75771
Anti Tag CoIP
33961781
Intra
RAD51B O15315 RAD51D Homo sapiens O75771
Electrophoresis
11751635
Intra
RAD51B O15315 RAD51D Homo sapiens O75771
GMS
11751635
Intra
RAD51B O15315 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
RAD51B O15315 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
RAD51B O15315 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
RAD51B O15315 RAD51C Homo sapiens O43502
Anti Tag CoIP
33961781
Intra
RAD51B O15315 RAD51C Homo sapiens O43502
GMS
11751635
Intra
RAD51B O15315 RAD51C Homo sapiens O43502
Y2H
9469824
Intra
RAD51B O15315 RAD51C Homo sapiens O43502
Anti Bait CoIP
11842113
Intra
RAD51B O15315 RAD51C Homo sapiens O43502
Electrophoresis
11751635
Intra
RAD51B O15315 RPAIN Homo sapiens Q86UA6
Y2H Array
32296183
Intra
RAD51B O15315 RPAIN Homo sapiens Q86UA6
Y2H Prey Pooling
32296183
Intra
RAD51B O15315 RPAIN Homo sapiens Q86UA6
Validated Y2H
32296183
Intra
RAD51B O15315 SWSAP1 Homo sapiens Q6NVH7
Anti Tag CoIP
21965664
Intra
RAD51B O15315 SWSAP1 Homo sapiens Q6NVH7
Pull Down
21965664
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Leiomyoma

Leiomyomatous Neoplasm

Leiomyomatous Tumor

Leiomyomas

Fibroid Tumor

Uterine Fibroids
Hereditary Breast Ovarian Cancer Syndrome

Hereditary Breast And Ovarian Cancer Syndrome

Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer

Breast And/Or Ovarian Cancer

Breast And Ovarian Cancer Syndrome

Hboc Syndrome

Hereditary Breast And Ovarian Cancer

Brca1- Brca2-Associated Hboc
Alcoholic Psychosis

Psychoses, Alcoholic

Alcoholic Psychoses
Leiomyoma, Uterine

Uterine Leiomyoma

Uterine Fibroid

Uterine Fibroids

Plexiform Leiomyoma

UL

Leiomyoma Of Corpus Uteri

Uterus Fibroma
Alcohol-Induced Mental Disorder

Psychoses, Alcoholic
Rectum Squamous Cell Carcinoma

Squamous Cell Carcinoma Of The Rectum

Rectal Squamous Cell Carcinoma

Squamous Carcinoma Of Rectum
Macular Degeneration, Age-Related, 1

Macular Degeneration

Age-Related Macular Degeneration

Macular Degeneration, Age-Related

Age Related Macular Degeneration

Age Related Macular Degeneration 1

ARMD1

Senile Macular Degeneration

Maculopathy, Age-Related, 1

Macular Degeneration, Age-Related, Reduced Risk Of

Age Related Maculopathy 1

Age Related Maculopathies

Age Related Maculopathy

Senile Macular Retinal Degeneration

Macular Degeneration Of Retina

Age-Related Maculopathy

Amd

Armd

Age-Related Maculopathy, Susceptibility To

Maculopathy Age-Related

Macular Degeneration, Age-Related, 1, Susceptibility To

Maculopathy, Age-Related

Macular Degeneration, Age-Related, Type 1

Macular Degeneration, Age-Related, 2
Cervix Melanoma
Plantar Fascial Fibromatosis

Dupuytren'S Contracture Of Foot

Ledderhose'S Disease

Fibromatosis, Plantar

Ledderhose Disease
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Uterine Benign Neoplasm
Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11607 RAD51B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta RAD51B VGNC VGNC:76647
Felis catus RAD51B VGNC VGNC:80873
Mus musculus RAD51B MGD MGI:1099436
Bos taurus RAD51B VGNC VGNC:33685
Rattus norvegicus RAD51B RGD RGD:1560681
Canis familiaris RAD51B VGNC VGNC:82294