Sh3rf1 - SH3 domain containing ring finger 1 Gene

Mus musculus

Also known as Posh; Sh3md2; 2200003J05Rik

Gene ID: 59009 | Gene type: protein coding

About Sh3rf1

Summary

Enables MAP-kinase scaffold activity. Involved in neuron migration; positive regulation of JNK cascade; and regulation of alpha-beta T cell activation. Located in lamellipodium. Is expressed in several structures, including central nervous system and genitourinary system. Orthologous to human SH3RF1 (SH3 domain containing ring finger 1). [provided by Alliance of Genome Resources, Apr 2022]

Sh3rf1 Products(1)

mRNA	Protein	Name
NM_021506.3	NP_067481.2	E3 ubiquitin-protein ligase SH3RF1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables MAP-kinase scaffold activity	IPI IPI: Inferred from physical interaction	23963642	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16230351	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in neuron migration	IMP IMP: Inferred from mutant phenotype	22959435	MGI
involved in positive regulation of JNK cascade	IMP IMP: Inferred from mutant phenotype	23963642	MGI
involved in regulation of CD4-positive, alpha-beta T cell differentiation	IMP IMP: Inferred from mutant phenotype	27084103	MGI
involved in regulation of CD8-positive, alpha-beta T cell proliferation	IMP IMP: Inferred from mutant phenotype	23963642	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in lamellipodium	IDA IDA: Inferred from direct assay	22959435	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase SH3RF1

RING-type E3 ubiquitin transferase SH3RF1	SH3 domain-containing RING finger protein 1
SH3 multiple domains 2	SH3 multiple domains protein 2
plenty of SH3 domains	plenty of SH3s
putative E3 ubiquitin-protein ligase SH3RF1

Sh3rf1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Sh3rf1	Q69ZI1	Bnip3l	Mus musculus	Q9Z2F7	Anti Tag CoIP	17095503
Intra	Sh3rf1	Q69ZI1	Bnip3l	Mus musculus	Q9Z2F7	Pull Down	17095503
Cross	Sh3rf1	Q69ZI1	SIAH1	Homo sapiens	Q8IUQ4	Anti Tag CoIP	16230351
Cross	Sh3rf1	Q69ZI1	SIAH1	Homo sapiens	Q8IUQ4	Pull Down	16230351

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12844	SH3RF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sh3rf1	NCBI	NCBI:57630

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