SAV1 - salvador family WW domain containing protein 1 Gene

Homo sapiens

Also known as SAV; WW45; WWP4

Gene ID: 60485 | Gene type: protein coding

About SAV1

Cytogenetic location: 14q22.1 Genomic coordinates (GRCh38): 14:50,633,580-50,668,306 (from NCBI)

This gene has 6 transcripts (splice variants), 210 orthologues and 6 paralogues. Ubiquitous expression in thyroid (RPKM 16.7), testis (RPKM 15.2) and 25 other tissues.

Summary

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced Apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor. [provided by RefSeq, Aug 2012]

SAV1 Products(1)

mRNA	Protein	Name
NM_021818.4	NP_068590.1	protein salvador homolog 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16930133	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16930133	GOA
enables protein serine/threonine kinase activator activity	IDA IDA: Inferred from direct assay	29063833	GOA
enables transcription regulator activator activity	IGI IGI: Inferred from genetic interaction	22292086	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in hippo signaling	IDA IDA: Inferred from direct assay	35429439	GOA
acts upstream of or within protein stabilization	IDA IDA: Inferred from direct assay	22292086	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	35429439	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	19212654	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19212654	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SAV1 Protein Structure

0
100
200
300
383 a.a.

Protein Preferred Names

Protein Names

protein salvador homolog 1

1700040G09Rik

SAV1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SAV1	Q9H4B6	STK3	Homo sapiens	Q13188	BioID	24255178
Intra	SAV1	Q9H4B6	STK3	Homo sapiens	Q13188	Y2H	20920251
Intra	SAV1	Q9H4B6	STK3	Homo sapiens	Q13188	Anti Tag CoIP	33961781
Intra	SAV1	Q9H4B6	STK3	Homo sapiens	Q13188	Anti Tag CoIP	24255178
Intra	SAV1	Q9H4B6	STK3	Homo sapiens	Q13188	Anti Tag CoIP	28514442
Intra	SAV1	Q9H4B6	STK3	Homo sapiens	Q13188	Y2H Array	32296183
Intra	SAV1	Q9H4B6	STK3	Homo sapiens	Q13188	Protein Kinase Assay	16930133
Intra	SAV1	Q9H4B6	STK3	Homo sapiens	Q13188	Y2H Prey Pooling	32296183
Intra	SAV1	Q9H4B6	STK3	Homo sapiens	Q13188	Anti Tag CoIP	24366813
Intra	SAV1	Q9H4B6	HAX1	Homo sapiens	O00165	Confocal	21567072
Intra	SAV1	Q9H4B6	STK4	Homo sapiens	Q13043	Anti Tag CoIP	16930133
Intra	SAV1	Q9H4B6	STK4	Homo sapiens	Q13043	Anti Tag CoIP	33961781
Intra	SAV1	Q9H4B6	STK4	Homo sapiens	Q13043	Anti Tag CoIP	24366813
Intra	SAV1	Q9H4B6	STK4	Homo sapiens	Q13043	BioID	24255178
Intra	SAV1	Q9H4B6	STK4	Homo sapiens	Q13043	Y2H	23386615
Intra	SAV1	Q9H4B6	STK4	Homo sapiens	Q13043	Y2H	20920251
Intra	SAV1	Q9H4B6	STK4	Homo sapiens	Q13043	Anti Tag CoIP	24255178

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Microphthalmia, Syndromic 10

MCOPS10	Moba
Microphthalmia And Brain Atrophy	Syndromic Microphthalmia 10
Microphthalmia-Brain Atrophy Syndrome	Microphthalmia Syndromic 10
Moba Syndrome	Syndromic Microphthalmia Type 10

Neurofibromatosis, Type Ii

Neurofibromatosis 2	Neurofibromatosis, Type 2
NF2	Neurofibromatosis Type Ii
Bilateral Acoustic Neurofibromatosis	Banf
Acn	Central Neurofibromatosis
Neurofibromatosis, Central Type	Acoustic Schwannomas, Bilateral
Acoustic Neurinoma, Bilateral	Bilateral Acoustic Neurinoma
Bilateral Acoustic Schwannomas	Familial Acoustic Neuromas

Sveinsson Chorioretinal Atrophy

SCRA	Atrophia Areata
Helicoid Peripapillary Chorioretinal Degeneration	Hpcd
Aa	Peripapillary Chorioretinal Degeneration, Icelandic Type
Helicoidal Peripapillary Chorioretinal Degeneration	Atrophy, Chorioretinal, Sveinsson

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12460	SAV1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SAV1	RGD	RGD:1307253
Bos taurus	SAV1	VGNC	VGNC:34300
Felis catus	SAV1	VGNC	VGNC:64882
Macaca mulatta	SAV1	VGNC	VGNC:77042
Mus musculus	SAV1	MGD	MGI:1927144
Canis familiaris	SAV1	VGNC	VGNC:45877
Others	SAV1	NCBI

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