Stx6 - syntaxin 6 Gene

Rattus norvegicus

Gene ID: 60562 | Gene type: protein coding

About Stx6

Summary

Predicted to enable SNAP receptor activity and syntaxin binding activity. Involved in synaptic vesicle to endosome fusion. Located in synaptic vesicle and trans-Golgi network membrane. Is integral component of membrane. Is integral component of synaptic vesicle membrane. Orthologous to human STX6 (syntaxin 6). [provided by Alliance of Genome Resources, Apr 2022]

Stx6 Products(1)

mRNA	Protein	Name
NM_031665.2	NP_113853.1	syntaxin-6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9243506	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in endocytic recycling	IDA IDA: Inferred from direct assay	30962439	RGD
involved in retrograde transport, endosome to Golgi	IDA IDA: Inferred from direct assay	30962439	RGD
involved in synaptic vesicle to endosome fusion	IDA IDA: Inferred from direct assay	17004320	RGD
involved in synaptic vesicle to endosome fusion	IMP IMP: Inferred from mutant phenotype	17004320	RGD
involved in vesicle-mediated transport	IDA IDA: Inferred from direct assay	8663448	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in recycling endosome	IDA IDA: Inferred from direct assay	30962439	RGD
is active in synaptic vesicle membrane	EXP EXP: Inferred from Experiment	17110340	RGD
is active in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	17004320	RGD
located in trans-Golgi network membrane	IDA IDA: Inferred from direct assay	9243506	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

syntaxin-6

Syn6

Stx6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Stx6	Q63635	EEA1	Homo sapiens	Q15075	Anti Tag CoIP	10506127
Cross	Stx6	Q63635	EEA1	Homo sapiens	Q15075	Y2H	10506127

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13986	STX6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Stx6	NCBI	NCBI:10228

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