SCOC - short coiled-coil protein Gene

Homo sapiens

Also known as SCOCO; UNC-69; HRIHFB2072

Gene ID: 60592 | Gene type: protein coding

About SCOC

This gene has 9 transcripts (splice variants) and 271 orthologues. Ubiquitous expression in brain (RPKM 55.6), thyroid (RPKM 34.6) and 25 other tissues.

Summary

This gene encodes a short coiled-coiled domain-containing protein that localizes to the Golgi apparatus. The encoded protein interacts with ADP-ribosylation factor-like proteins. Pseudogenes of this gene are found on chromosomes 1 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

SCOC Products(8)

mRNA	Protein	Name
NM_001153446.1	NP_001146918.1	short coiled-coil protein isoform 4
NM_001153484.2	NP_001146956.2	short coiled-coil protein isoform 1
NM_001153552.2	NP_001147024.2	short coiled-coil protein isoform 3
NM_001153585.1	NP_001147057.1	short coiled-coil protein isoform 4
NM_001153635.1	NP_001147107.1	short coiled-coil protein isoform 5
NM_001153663.1	NP_001147135.1	short coiled-coil protein isoform 2
NM_001153690.1	NP_001147162.1	short coiled-coil protein isoform 6
NM_032547.3	NP_115936.2	short coiled-coil protein isoform 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20195357	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of macroautophagy	IDA IDA: Inferred from direct assay	22354037	GOA
involved in regulation of protein complex stability	IMP IMP: Inferred from mutant phenotype	22354037	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
colocalizes with endosome	IDA IDA: Inferred from direct assay	22354037	GOA
colocalizes with trans-Golgi network	IDA IDA: Inferred from direct assay	22354037	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCOC Protein Structure

DUF2205

0
100
159 a.a.

Protein Preferred Names

Protein Names

short coiled-coil protein

SCOC Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SCOC	Q9UIL1	SCHIP1	Homo sapiens	P0DPB3	TAP	20195357
Intra	SCOC	Q9UIL1	FEZ1	Homo sapiens	Q99689	IF	22354037
Intra	SCOC	Q9UIL1	TCF4	Homo sapiens	P15884	Validated Y2H	25416956
Intra	SCOC	Q9UIL1	TCF4	Homo sapiens	P15884	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Carotid Artery Dissection

Dissection Of Carotid Artery

Cannabis Dependence

Marijuana Abuse	Cannabinoid Addiction
Cannabinoid Dependence	Cannabis Addiction

Hallucinogen Dependence

Hallucinogen Addiction

Pyromania

Firesetting Behavior	Pathological Firesetting
Pathological Fire-Setting

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12558	SCOC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SCOC	RGD	RGD:1311860
Bos taurus	SCOC	VGNC	VGNC:34360
Mus musculus	SCOC	MGD	MGI:1927654

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