FEZ1 - fasciculation and elongation protein zeta 1 Gene

Homo sapiens

Also known as UNC-76

Gene ID: 9638 | Gene type: protein coding

About FEZ1

Cytogenetic location: 11q24.2 Genomic coordinates (GRCh38): 11:125,442,881-125,496,265 (from NCBI)

This gene has 17 transcripts (splice variants), 219 orthologues and 1 paralogue. Biased expression in brain (RPKM 74.3), urinary bladder (RPKM 9.7) and 4 other tissues.

Summary

This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described. [provided by RefSeq, Jul 2008]

FEZ1 Products(2)

mRNA	Protein	Name
NM_005103.5	NP_005094.1	fasciculation and elongation protein zeta-1 isoform 1
NM_022549.4	NP_072043.1	fasciculation and elongation protein zeta-1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14690447	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of autophagosome assembly	IMP IMP: Inferred from mutant phenotype	25495476	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	25495476	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FEZ1 Protein Structure

FEZ

0
100
200
300
392 a.a.

Protein Preferred Names

Protein Names

fasciculation and elongation protein zeta-1

zygin I

FEZ1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FEZ1	Q99689	SCOC	Homo sapiens	Q9UIL1	Anti Tag CoIP	33961781
Intra	FEZ1	Q99689	NEK1	Homo sapiens	Q96PY6	Pull Down	14690447
Intra	FEZ1	Q99689	NEK1	Homo sapiens	Q96PY6	Y2H	14690447
Intra	FEZ1	Q99689	HTT	Homo sapiens	P42858	Y2H	17500595
Intra	FEZ1	Q99689	HTT	Homo sapiens	P42858	Anti Tag CoIP	28514442
Intra	FEZ1	Q99689	HTT	Homo sapiens	P42858	Pull Down	15383276
Intra	FEZ1	Q99689	CEP126	Homo sapiens	Q9P2H0	Y2H	15383276
Intra	FEZ1	Q99689	TXNDC9	Homo sapiens	O14530	Anti Tag CoIP	16169070

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Lissencephaly 1

LIS1	Classic Lissencephaly
Ils	Subcortical Laminar Heterotopia
Lissencephaly Due To Lis1 Mutation	Lissencephaly Sequence, Isolated
Lissencephaly, Classic	Pafah1b1-Related Lissencephaly
Classical Lissencephaly	Lissencephaly Type 1
Lissencephaly-1	Subcortical Band Heterotopia
Double Cortex	Lissencephaly Classic
Lissencephaly Sequence Isolated	Isolated Lissencephaly Sequence
Type 1 Lissencephaly	Lissencephaly Syndrome Type 1
SBH	Sclh
Lissencephaly, Type 1	Type I Lissencephaly

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Jacobsen Syndrome

Chromosome 11q Deletion Syndrome	Partial 11q Monosomy Syndrome
Jacobsen Distal 11q Deletion Syndrome	JBS
11q Partial Monosomy Syndrome	Chromosome 11q Deletion
11q Deletion	11q Monosomy
Deletion 11q	Monosomy 11q
Partial Monosomy 11q	11q Deletion Disorder
11q Deletion Syndrome	11q Terminal Deletion Disorder
11q- Deletion Syndrome	11q23 Deletion Disorder
Jacobsen Thrombocytopenia	11q Terminal Deletion Syndrome
Del(11)(Q23.3)	Del(11)(Qter)
Distal Deletion 11q	Distal Monosomy 11q
Monosomy 11qter	Telomeric Deletion 11q
Paris-Trousseau Thrombocytopenia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04870	FEZ1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	FEZ1	VGNC	VGNC:72639
Mus musculus	FEZ1	MGD	MGI:2670976
Rattus norvegicus	FEZ1	RGD	RGD:619708
Felis catus	FEZ1	VGNC	VGNC:62234
Canis familiaris	FEZ1	VGNC	VGNC:40827
Bos taurus	FEZ1	VGNC	VGNC:28957

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