2. Gene
  3. RIC8A - RIC8 guanine nucleotide exchange factor A Gene

RIC8A - RIC8 guanine nucleotide exchange factor A Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as RIC8

Gene ID: 60626 | Gene type: protein coding

About RIC8A

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:207,708-215,113 (from NCBI)

This gene has 17 transcripts (splice variants), 187 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 20.2), brain (RPKM 15.3) and 25 other tissues.

Summary

Predicted to enable G-protein alpha-subunit binding activity; GTPase activator activity; and guanyl-nucleotide exchange factor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within several processes, including basement membrane organization; gastrulation; and visual learning. Predicted to be located in membrane. Predicted to be active in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

RIC8A Products(4)

mRNA Protein Name
NM_001286134.2 NP_001273063.1 synembryn-A isoform 2
NM_001386941.1 NP_001373870.1 synembryn-A isoform 3
NM_001386942.1 NP_001373871.1 synembryn-A isoform 4
NM_021932.6 NP_068751.4 synembryn-A isoform 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RIC8A Protein Structure

Ric8

Ric8: Guanine nucleotide exchange factor synembryn (66 - 498)

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  • 531 a.a.
Protein Preferred Names Protein Names

synembryn-A

resistance to inhibitors of cholinesterase 8 homolog A

RIC8A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
RIC8A Q9NPQ8 GNAI1 Homo sapiens P63096
Y2H
21988832
Intra
RIC8A Q9NPQ8 GNAI1 Homo sapiens P63096
Anti Tag CoIP
33961781
Intra
RIC8A Q9NPQ8 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
16713569
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-122579 IGS-1.76 Inhibitor 98.57% Unkown
HY-RS11967 RIC8A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-121503 FD44 / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RIC8A MGD MGI:2141866
Macaca mulatta RIC8A VGNC VGNC:76863
Rattus norvegicus RIC8A RGD RGD:727957
Canis familiaris RIC8A VGNC VGNC:45572
Felis catus RIC8A VGNC VGNC:64624
Bos taurus RIC8A VGNC VGNC:33961