2. Gene
  3. GNAI1 - G protein subunit alpha i1 Gene

GNAI1 - G protein subunit alpha i1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as Gi; HG1B; NEDHISB

Gene ID: 2770 | Gene type: protein coding

About GNAI1

Cytogenetic location: 7q21.11 Genomic coordinates (GRCh38): 7:80,134,831-80,226,181 (from NCBI)

This gene has 32 transcripts (splice variants), 224 orthologues, 15 paralogues and is associated with 2 phenotypes. Ubiquitous expression in fat (RPKM 39.3), brain (RPKM 28.1) and 22 other tissues.

Summary

Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The alpha subunit binds guanine nucleotide, can hydrolyze GTP, and can interact with Other proteins. The protein encoded by this gene represents the alpha subunit of an inhibitory complex. The encoded protein is part of a complex that responds to beta-adrenergic signals by inhibiting Adenylate Cyclase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GNAI1 Products(2)

mRNA Protein Name
NM_001256414.2 NP_001243343.1 guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 2
NM_002069.6 NP_002060.4 guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables D2 dopamine receptor binding IPI
IPI: Inferred from physical interaction
33571431 GOA
enables G protein activity IDA
IDA: Inferred from direct assay
16204467 GOA
enables GTP binding IDA
IDA: Inferred from direct assay
34685729 GOA
enables GTPase activity IDA
IDA: Inferred from direct assay
8774883 GOA
enables adenylate cyclase regulator activity IDA
IDA: Inferred from direct assay
33762731 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15537540 GOA
Biological Process GO Annotation Evidence Reference Source
involved in T cell migration IDA
IDA: Inferred from direct assay
20829352 GOA
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
16204467 GOA
involved in adenylate cyclase-inhibiting serotonin receptor signaling pathway IDA
IDA: Inferred from direct assay
33762731 GOA
involved in cell division IMP
IMP: Inferred from mutant phenotype
17635935 GOA
involved in positive regulation of cholesterol biosynthetic process IDA
IDA: Inferred from direct assay
38503280 GOA
involved in positive regulation of protein localization to cell cortex IMP
IMP: Inferred from mutant phenotype
22327364 GOA
involved in regulation of mitotic spindle organization IMP
IMP: Inferred from mutant phenotype
23027904 GOA
involved in response to prostaglandin E IDA
IDA: Inferred from direct assay
16204467 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cell cortex IDA
IDA: Inferred from direct assay
22327364 GOA
located in centrosome IDA
IDA: Inferred from direct assay
17635935 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
17635935 GOA
is active in cytosol IDA
IDA: Inferred from direct assay
17635935 GOA
part of heterotrimeric G-protein complex IDA
IDA: Inferred from direct assay
33762731 GOA
located in midbody IDA
IDA: Inferred from direct assay
17635935 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
17635935 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GNAI1 Protein Structure

G-alpha

G-alpha: G-protein alpha subunit (6 - 343)

  • 0
  • 100
  • 200
  • 300
  • 354 a.a.
Protein Preferred Names Protein Names

guanine nucleotide-binding protein G(i) subunit alpha-1

Gi1 protein alpha subunit

GNAI1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra GNAI1 P63096 PCP2 Homo sapiens Q8IVA1
Y2H Prey Pooling
32296183
Intra GNAI1 P63096 PCP2 Homo sapiens Q8IVA1
Validated Y2H
32296183
Intra GNAI1 P63096 PCP2 Homo sapiens Q8IVA1
Y2H Array
32296183
Intra GNAI1 P63096 GPSM3 Homo sapiens Q9Y4H4
Validated Y2H
32296183
Intra GNAI1 P63096 RGS17 Homo sapiens Q9UGC6
Y2H Prey Pooling
25416956
Intra GNAI1 P63096 NUMA1 Homo sapiens Q14980
Anti Tag CoIP
15537540
Intra GNAI1 P63096 NUMA1 Homo sapiens Q14980
IF
15537540
Intra GNAI1 P63096 GPSM2 Homo sapiens P81274
Anti Tag CoIP
15537540
Intra GNAI1 P63096 GPSM2 Homo sapiens P81274
IF
15537540
Intra GNAI1 P63096 RIC8A Homo sapiens Q9NPQ8
Anti Tag CoIP
33961781
Intra GNAI1 P63096 RGS14 Homo sapiens O43566
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Neurodevelopmental Disorder With Hypotonia, Impaired Speech, And Behavioral Abnormalities

NEDHISB
Cholera

Vibrio Cholerae Infection

Cholera - Vibrio Cholerae

Cholera Due To Vibrio Cholerae

Vibrio Cholerae

Cholera Syndrome

Asiatic Cholera

Epidemic Cholera
Pertussis

Whooping Cough

Bordetella Infections

Bordetella Infection

Bordetella Pertussis Infection

Wc - Whooping Cough

Whooping Cough Due To Unspecified Organism

Bordetellosis

Tussis Convulsiva

Whooping Cough, Unspecified Organism

Wc - [Whooping Cough]

Whooping Cough Due To B. Parapertussis

Infection Due To Bordetella Parapertussis
Congenital Stationary Night Blindness

Night Blindness, Congenital Stationary

Congenital Essential Nyctalopia

Oguchi Disease

Blindness, Night, Stationary, Congenital
Night Blindness

Nyctalopia
Pilomyxoid Astrocytoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05534 GNAI1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GNAI1 MGD MGI:95771
Canis familiaris GNAI1 VGNC VGNC:41301
Bos taurus GNAI1 VGNC VGNC:29449
Felis catus GNAI1 VGNC VGNC:62616
Rattus norvegicus GNAI1 RGD RGD:2713
Macaca mulatta GNAI1 VGNC VGNC:73089
Others GNAI1 NCBI